Dihydrofolate:MCnc:Pt:Ser:Qn

In the present work, we propose to design drugs that target the enzyme dihydrofolate redutase (DHFR) as a means of a novel drug… (More)

Candida glabrata, a fungal strain resistant to many commonly administered antifungal agents, has become an emerging threat to… (More)

Previous studies from this laboratory have shown that the addition of leucovorin to tumor cells dissociates methotrexate, but not… (More)

There are major differences between the structures of human dihydrofolate reductase (hDHFR) and Mycobacterium tuberculosis… (More)

Until recently, the only selenium containing amino acid which could be used to completely substitute for a wild type amino acid… (More)

A new method is proposed for docking ligands into proteins in cases where an NMR-determined solution structure of a related… (More)

Vorom is a computer-aided method of drug design which can model a biological receptor given only binding data of known ligands… (More)

The pathway for de novo biosynthesis of purine nucleotides contains two one-carbon transfer reactions catalyzed by glycinamide… (More)

The effect of methotrexate (MTX) on thymidylate synthetase activity during liver regeneration was examined with parenchymal cells… (More)