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diaziquone

Known as: 2,5-bis(1-aciridinyl)-3,6-bis(ethoxycarbonylamino)-1,4-benzoquinone, 1,4-cyclohexadiene-1,4-dicarbamic acid, 2, 5-bis(1-aziridinyl)-3,6-dioxo-, diethyl ester, Aziridinyl Benzoquinone 
A water-soluble, synthetic aziridinylbenzoquinone with potential antineoplastic activity. Bioactivation of aziridinylbenzoquinone RH1 occurs through… 
National Institutes of Health

Related topics

Related topics

10 relations

Broader (5)

1,4-benzoquinoneAntineoplastic AgentsAziridinesBenzoquinones

Narrower (2)

CI-904NSC 182986
NCIt Antineoplastic Agent Terminologyaziridinecyclophosphamide/diaziquone

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
1984
Highly Cited
1984
DNA strand scission and cross-linking by diaziridinylbenzoquinone (diaziquone) in human cells and relation to cell killing.
The effects of 3,6-diaziridinyl-2,5-bis(carboethoxyamino)-1,4-benzoquinone (diaziquone; AZQ) on various cell types were studied… 
1983
1983
Involvement of histidine residues in the activity of horse liver alcohol dehydrogenase.
X-ray crystallographic studies indicate that His-51 in alcohol dehydrogenase may participate in a proton relay system during… 
1982
1982
Biochemical activation of AZQ [3,6-diaziridinyl-2,5-bis(carboethoxyamino)-1,4-benzoquinone] to its free radical species.
The aziridinyl quinone 3,6-diaziridinyl-2,5-bis(carboethoxyamino)-1,4-benzoquinone is an antitumor agent that enhances electron… 
1982
1982
Phase I trial and pharmacokinetics of aziridinylbenzoquinone (NSC 182986) in humans.
2,5-Diaziridinyl-3,6-(carboethoxyamino)-1,4-benzoquinone (AZQ) is a rationally designed antitumor agent which possesses… 
1981
1981
2,5-Diaziridinyl-3,6-bis(carboethoxyamino)-1,4-benzoquinone II: Isolation and characterization of degradation products.
A direct high-performance liquid chromatographic (HPLC) method was applied to monitor 2,5-diaziridinyl-3,6-bis(carboethoxyamino… 
1981
1981
Ability of a new antitumor agent, AZQ, to penetrate into cerebrospinal fluid.
The ability of a new antitumor agent, AZQ (2,5-diaziridinyl-3,6-bis-carboethoxyamino-1,4-benzoquinone), NSC No. 182986, to enter… 
1981
1981
2,5-Diaziridinyl-3,6-bis(carboethoxyamino)-1,4-benzoquinone I: Kinetics in aqueous solutions by high-performance liquid chromatography.
The application of a rapid, selective, and sensitive reversed-phase high-performance liquid chromatographic method to the… 
Highly Cited
1979
Highly Cited
1979
Triethyltin binding to cat haemoglobin. Evidence for two chemically distinct sites and a role for both histidine and cysteine residues.
Triethyltin binding to cat haemoglobin was measured after pretreatment of the protein with diethyl pyrocarbonate at pH 6.0… 
Review
1977
Review
1977
Adsorption of Parathion, Fenitrothion, Methyl Parathion, Aminoparathion and Paraoxon by Na+, Ca2+, and Fe3+ Montmorillonite Suspensions 1
This study was conducted to investigate the influence of the saturating cation on the adsorption of parathion, methyl parathion… 
1969
1969
Polyribosome isolation in the presence of diethyl pyrocarbonate.
Isolation of polyribosomes from wheat embryos and corn root tips in the presence of diethyl pyrocarbonate showed this reagent to… 
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