dehydrosqualene
National Institutes of Health
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Dehydrosqualene synthase (CrtM) is a key enzyme in the synthesis of presqualene diphosphate in Staphylococcus aureus. In the…
C30 carotenoids, which have shorter backbones than C40 carotenoids, are known to be produced in the pathogenic bacterium…
We report X-ray crystallographic structures of three inhibitors bound to dehydrosqualene synthase from Staphylococcus aureus: 1…
One of the truisms in the medicinal chemistry of antibiotics is that there can never be enough scaffolds and structures, whether…
We have isolated and characterized two overlapping cDNA clones for Arabidopsis thaliana squalene synthase. Their nucleotide…
Squalene, dehydrosqualene and related hydrocarbons were found to constitute an essential part of the neutral lipid fraction…
When microsomal fraction of Saccharomyces cerevisiae was incubated with farnesyl pyrophosphate or presqualene pyrophosphate in…