U. Gräfe

Publications221
h-index27
Citations2,760
Highly Influential Citations51
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New and bioactive compounds from Streptomyces strains residing in the wood of Celastraceae
TLDR
Wood from three different plants of the Celastraceae growing in their natural habitats in Brazil and South Africa was established as a source of endophytic bacteria using a medium selective for actinomycetes, and two isolates were identified as Streptomyces setonii and S. sampsonii.
The occurrence of peptaibols and structurally related peptaibiotics in fungi and their mass spectrometric identification via diagnostic fragment ions
TLDR
The paper compiles fragmentation data of pseudo‐molecular ions reported in the literature as a guide to the rational identification of recurrently isolated and new peptaibols and peptibiotics.
Colossolactones, new triterpenoid metabolites from a Vietnamese mushroom Ganoderma colossum.
Seven new triterpenoid metabolites (colossolactones; 1-7) were isolated from a fruiting body of Ganoderma colossum, and their structures were determined by MS and NMR methods.
New macrolides and furan carboxylic acid derivative from the sponge-derived fungus Cladosporium herbarum.
TLDR
Bioassay-guided fractionation of organic extracts of Cladosporium herbarum yielded two new macrolide metabolites that were isolated from the marine sponge Callyspongia aerizusa and the antimicrobially active furan carboxylic acids: Sumiki's acid and its new derivative, acetyl Sumiki’s acid.
A novel type of nonsteroidal estrone sulfatase inhibitors.
TLDR
The initial results and structure-activity relationships of this study into a series of thiosemicarbazone derivatives of madurahydroxylactone as potential nonsteroidal inhibitors of the enzyme estrone sulfatase showed low acute toxicity in the hen's fertile egg screening test.
Alnumycin a new naphthoquinone antibiotic produced by an endophytic Streptomyces sp.
TLDR
The culture broth (5 liters) was separated by filtration followed by concentration under reduced pressure (1 l iter) and extraction with ethyl acetate (3×1 liter) and the bioactive fractions were determined.
New diketopiperazine alkaloids from Penicillium fellutanum.
Four new diketopiperazine alkaloids (1-4) were isolated from cultures of Penicillium fellutanum, and their structures were determined by MS and NMR measurements.
Aurantimycins, new depsipeptide antibiotics from Streptomyces aurantiacus IMET 43917. Production, isolation, structure elucidation, and biological activity.
TLDR
Aurantimycins were isolated from the mycelium of Streptomyces aurantiacus JA 4570 as new representatives of the azinothricin group of hexadepsipeptide antibiotics and display strong activity against Gram-positive bacteria and cytotoxic effects against L-929 mouse fibroblast cells.
Differences in membrane pore formation by peptaibols
TLDR
Highly membrane‐active structures such as alamethicin F‐30, chrysospermin C, texenomycin A and paracelsin A displayed antibiotic effects against the fungus and toxicity in mice and no or weak membrane activities corresponded with biological inactivity.
Nocardicyclins A and B: new anthracycline antibiotics produced by Nocardia pseudobrasiliensis.
TLDR
Nocardicyclins A (1) and B (2), new anthracycline antibiotics have been isolated from the mycelial cake of Nocardia pseudobrasiliensis IFM 0624 (JCM 9894) and are active against Gram-positive bacteria including Mycobacterium spp.
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