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dehydroretronecine

Known as: 6,7-dihydro-7-hydroxy-1-hydroxymethyl-5H-pyrrolizine, dehydro-retronecine, dehydroretro-necine 
National Institutes of Health

Related topics

Related topics

5 relations

Broader (2)

CarcinogensMonocrotaline
analogs & derivatives

Narrower (2)

dehydroretronecine, (R)-isomerdehydroretronecine, (S)-isomer

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2001
2001
Development of a (32)P-postlabeling/HPLC method for detection of dehydroretronecine-derived DNA adducts in vivo and in vitro.
Pyrrolizidine alkaloids are naturally occurring genotoxic chemicals produced by a large number of plants. Metabolism of… 
1996
1996
Metabolic activation of pyrrolizidine alkaloids by human, rat and avocado microsomes.
Highly Cited
1995
Highly Cited
1995
Pyrrolizidine alkaloid-induced DNA-protein cross-links.
Pyrrolizidine alkaloids (PAs) are potent carcinogenic and anti-mitotic compounds produced by a large number of plant species. In… 
1988
1988
Synthesis and antineoplastic activity of 5-aryl-2,3-dihydropyrrolo[2,1-b]thiazole-6,7-dimethanol 6,7-bis(isopropylcarbamates).
A series of 1-thia analogues of the pyrrolizine bis(carbamate) 9 (NSC-278214), namely 5-aryl-2,3-dihydropyrrolo-[2,1-b]thiazole-6… 
1988
1988
Crosslinking of DNA by dehydroretronecine, a metabolite of pyrrolizidine alkaloids.
Dehydroretronecine (DHR), a major metabolite of the pyrrolizidine alkaloids, has been shown to bind and crosslink pBR322 plasmid… 
1985
1985
Configuration of necine pyrroles--toxic metabolites of pyrrolizidine alkaloids.
1982
1982
Carcinogenicity of some pyrrolic pyrrolizidine alkaloid metabolites and analogues.
1978
1978
Dehydroretronecine-induced skin tumors in mice.
Female Swiss mice susceptible to skin tumors received 6 sc injections and/or topical applications of dehydroretronecine, a… 
Highly Cited
1976
Highly Cited
1976
Neoplastic transformation in tissues of rats exposed to monocrotaline or dehydroretronecine.
Male Sprague-Dawley rats received sc injections biweekly of either the pyrrolizidine alkaloid monocrotaline or its metabolite… 
1975
1975
Binding of tritiated dehydroretronecine to macromolecules.
In vivo and in vitro experiments have shown that the pyrrolizidine alkaloid metabolite dehydroretronecine binds readily to… 
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