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dehydroretronecine

Known as: 6,7-dihydro-7-hydroxy-1-hydroxymethyl-5H-pyrrolizine, dehydro-retronecine, dehydroretro-necine 
National Institutes of Health

Related topics

Related topics

5 relations

Broader (2)

CarcinogensMonocrotaline
analogs & derivatives

Narrower (2)

dehydroretronecine, (R)-isomerdehydroretronecine, (S)-isomer

Papers overview

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1996
1996
Metabolic activation of pyrrolizidine alkaloids by human, rat and avocado microsomes.
1994
1994
Quantitation of the hepatic release of metabolites of the pyrrolizidine alkaloid, monocrotaline.
Pyrrolizidine alkaloids such as monocrotaline are bioactivated in the liver to pneumotoxins that cause pulmonary arterial… 
1988
1988
Synthesis and antineoplastic activity of 5-aryl-2,3-dihydropyrrolo[2,1-b]thiazole-6,7-dimethanol 6,7-bis(isopropylcarbamates).
A series of 1-thia analogues of the pyrrolizine bis(carbamate) 9 (NSC-278214), namely 5-aryl-2,3-dihydropyrrolo-[2,1-b]thiazole-6… 
1988
1988
Crosslinking of DNA by dehydroretronecine, a metabolite of pyrrolizidine alkaloids.
Dehydroretronecine (DHR), a major metabolite of the pyrrolizidine alkaloids, has been shown to bind and crosslink pBR322 plasmid… 
1985
1985
Configuration of necine pyrroles--toxic metabolites of pyrrolizidine alkaloids.
1985
1985
The ability of bifunctional and monofunctional pyrrole compounds to induce sister-chromatid exchange (SCE) in human lymphocytes and mutations in Salmonella typhimurium.
1982
1982
Carcinogenicity of some pyrrolic pyrrolizidine alkaloid metabolites and analogues.
1978
1978
Dehydroretronecine-induced skin tumors in mice.
Female Swiss mice susceptible to skin tumors received 6 sc injections and/or topical applications of dehydroretronecine, a… 
1975
1975
Binding of tritiated dehydroretronecine to macromolecules.
In vivo and in vitro experiments have shown that the pyrrolizidine alkaloid metabolite dehydroretronecine binds readily to… 
1974
1974
Antimitotic Effects of Dehydroretronecine Pyrrole 1
  • J. AllenI. Hsu
  • Proceedings of the Society for Experimental…
  • 1974
  • Corpus ID: 40418484
Summary When dehydroretronecine, a metabolite of the pyrrolizidine alkaloid monocrotaline, is given subcutaneously to rats at… 
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