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dehydroretronecine

Known as: 6,7-dihydro-7-hydroxy-1-hydroxymethyl-5H-pyrrolizine, dehydro-retronecine, dehydroretro-necine 
 
National Institutes of Health

Papers overview

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2013
2013
A series of novel hybrid spiro heterocycles comprising pyrrolizine, spiroxindole and piperidine moieties was synthesized chemo… Expand
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Highly Cited
2005
Highly Cited
2005
Retronecine-based pyrrolizidine alkaloids, such as riddelliine, retrorsine, and monocrotaline, are toxic to domestic livestock… Expand
Highly Cited
2001
Highly Cited
2001
Riddelliine is a representative naturally occurring genotoxic pyrrolizidine alkaloid. We have studied the mechanism by which… Expand
1988
1988
A series of 1-thia analogues of the pyrrolizine bis(carbamate) 9 (NSC-278214), namely 5-aryl-2,3-dihydropyrrolo-[2,1-b]thiazole-6… Expand
Highly Cited
1982
Highly Cited
1982
Dehydroretronecine, an antimitotic and carcinogenic agent, reacted with deoxyguanosine at pH 7.4 in vitro to yield in nearly… Expand
Highly Cited
1978
Highly Cited
1978
Monocrotaline was placed in the drinking water of rats at a concentration of 20 mg per liter for periods of up to three weeks… Expand
Highly Cited
1977
Highly Cited
1977
The covalent interaction of dehydroretronecine, a carcinogenic metabolite of the pyrrolizidine alkaloid monocrotaline, with… Expand
1976
1976
Male Sprague-Dawley rats received sc injections biweekly of either the pyrrolizidine alkaloid monocrotaline or its metabolite… Expand
Highly Cited
1976
Highly Cited
1976
62 pyrrolizidine alkaloids and derivatives have been screened for acute and chronic hepato- and pneumotoxicity by the single dose… Expand
Highly Cited
1975
Highly Cited
1975
Two groups of rat were given s.c. injections of either monocrotaline or its major detectable metabolite, dehydroretronecine… Expand
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