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dehydroretronecine
Known as:
6,7-dihydro-7-hydroxy-1-hydroxymethyl-5H-pyrrolizine
, dehydro-retronecine
, dehydroretro-necine
National Institutes of Health
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Related topics
Related topics
5 relations
Broader (2)
Carcinogens
Monocrotaline
analogs & derivatives
Narrower (2)
dehydroretronecine, (R)-isomer
dehydroretronecine, (S)-isomer
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2016
Highly Cited
2016
Cytotoxicity of pyrrolizidine alkaloid in human hepatic parenchymal and sinusoidal endothelial cells: Firm evidence for the reactive metabolites mediated pyrrolizidine alkaloid-induced hepatotoxicity…
Mengbi Yang
,
Jianqing Ruan
,
P. Fu
,
G. Lin
Chemico-Biological Interactions
2016
Corpus ID: 21867744
Highly Cited
2013
Highly Cited
2013
A facile chemo-, regio- and stereoselective synthesis and cholinesterase inhibitory activity of spirooxindole-pyrrolizine-piperidine hybrids.
Y. Kia
,
H. Osman
,
+4 authors
I. A. Razak
Bioorganic & Medicinal Chemistry Letters
2013
Corpus ID: 206256377
Highly Cited
2005
Highly Cited
2005
Human liver microsomal reduction of pyrrolizidine alkaloid N-oxides to form the corresponding carcinogenic parent alkaloid.
Yu-Ping Wang
,
Jian Yan
,
P. Fu
,
M. Chou
Toxicology Letters
2005
Corpus ID: 21331965
2003
2003
Correlation of DNA adduct formation and riddelliine-induced liver tumorigenesis in F344 rats and B6C3F(1) mice.
M. Chou
,
Jian Yan
,
+4 authors
P. Fu
Cancer Letters
2003
Corpus ID: 45618420
Highly Cited
1989
Highly Cited
1989
Simple procedures for preparing putative toxic metabolites of pyrrolizidine alkaloids.
A. Mattocks
,
R. Jukes
,
J. Brown
Toxicon
1989
Corpus ID: 45524101
Highly Cited
1982
Highly Cited
1982
Alkylation of N2 in deoxyguanosine by dehydroretronecine, a carcinogenic metabolite of the pyrrolizidine alkaloid monocrotaline.
K. Robertson
Cancer Research
1982
Corpus ID: 36420267
Dehydroretronecine, an antimitotic and carcinogenic agent, reacted with deoxyguanosine at pH 7.4 in vitro to yield in nearly…
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Highly Cited
1978
Highly Cited
1978
The effect of a pyrrolizidine alkaloid, monocrotaline, and a pyrrole, dehydroretronecine, on the biochemical functions of the pulmonary endothelium.
R. Huxtable
,
D. Ciaramitaro
,
D. Eisenstein
Molecular Pharmacology
1978
Corpus ID: 26253834
Monocrotaline was placed in the drinking water of rats at a concentration of 20 mg per liter for periods of up to three weeks…
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Highly Cited
1977
Highly Cited
1977
Covalent interaction of dehydroretronecine, a carcinogenic metabolite of the pyrrolizidine alkaloid monocrotaline, with cysteine and glutathione.
K. Robertson
,
J. L. Seymour
,
M. Hsia
,
J. Allen
Cancer Research
1977
Corpus ID: 21309287
The covalent interaction of dehydroretronecine, a carcinogenic metabolite of the pyrrolizidine alkaloid monocrotaline, with…
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Highly Cited
1976
Highly Cited
1976
Hepato- and pneumotoxicity of pyrrolizidine alkaloids and derivatives in relation to molecular structure.
C. Culvenor
,
J. Edgar
,
M. Jago
,
A. Qutteridge
,
J. Peterson
,
L. W. Smith
Chemico-Biological Interactions
1976
Corpus ID: 46112880
Highly Cited
1975
Highly Cited
1975
Dehydroretronecine-induced rhabdomyosarcomas in rats.
J. Allen
,
I. Hsu
,
L. Carstens
Cancer Research
1975
Corpus ID: 9203563
Two groups of rat were given s.c. injections of either monocrotaline or its major detectable metabolite, dehydroretronecine…
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