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dehydroretronecine

Known as: 6,7-dihydro-7-hydroxy-1-hydroxymethyl-5H-pyrrolizine, dehydro-retronecine, dehydroretro-necine 
National Institutes of Health

Related topics

Related topics

5 relations

Broader (2)

CarcinogensMonocrotaline
analogs & derivatives

Narrower (2)

dehydroretronecine, (R)-isomerdehydroretronecine, (S)-isomer

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2016
Highly Cited
2016
Cytotoxicity of pyrrolizidine alkaloid in human hepatic parenchymal and sinusoidal endothelial cells: Firm evidence for the reactive metabolites mediated pyrrolizidine alkaloid-induced hepatotoxicity…
Highly Cited
2013
Highly Cited
2013
A facile chemo-, regio- and stereoselective synthesis and cholinesterase inhibitory activity of spirooxindole-pyrrolizine-piperidine hybrids.
Highly Cited
2005
Highly Cited
2005
Human liver microsomal reduction of pyrrolizidine alkaloid N-oxides to form the corresponding carcinogenic parent alkaloid.
2003
2003
Correlation of DNA adduct formation and riddelliine-induced liver tumorigenesis in F344 rats and B6C3F(1) mice.
Highly Cited
1989
Highly Cited
1989
Simple procedures for preparing putative toxic metabolites of pyrrolizidine alkaloids.
Highly Cited
1982
Highly Cited
1982
Alkylation of N2 in deoxyguanosine by dehydroretronecine, a carcinogenic metabolite of the pyrrolizidine alkaloid monocrotaline.
Dehydroretronecine, an antimitotic and carcinogenic agent, reacted with deoxyguanosine at pH 7.4 in vitro to yield in nearly… 
Highly Cited
1978
Highly Cited
1978
The effect of a pyrrolizidine alkaloid, monocrotaline, and a pyrrole, dehydroretronecine, on the biochemical functions of the pulmonary endothelium.
Monocrotaline was placed in the drinking water of rats at a concentration of 20 mg per liter for periods of up to three weeks… 
Highly Cited
1977
Highly Cited
1977
Covalent interaction of dehydroretronecine, a carcinogenic metabolite of the pyrrolizidine alkaloid monocrotaline, with cysteine and glutathione.
The covalent interaction of dehydroretronecine, a carcinogenic metabolite of the pyrrolizidine alkaloid monocrotaline, with… 
Highly Cited
1976
Highly Cited
1976
Hepato- and pneumotoxicity of pyrrolizidine alkaloids and derivatives in relation to molecular structure.
Highly Cited
1975
Highly Cited
1975
Dehydroretronecine-induced rhabdomyosarcomas in rats.
Two groups of rat were given s.c. injections of either monocrotaline or its major detectable metabolite, dehydroretronecine… 
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