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Monocrotaline

Known as: 20-Norcrotalanan-11,15-dione, 14,19-dihydro-12,13-dihydroxy-, (13alpha,14alpha)-, Monocrotaline [Chemical/Ingredient] 
A pyrrolizidine alkaloid and a toxic plant constituent that poisons livestock and humans through the ingestion of contaminated grains and other foods… 
National Institutes of Health

Related topics

Related topics

12 relations

Broader (1)

Alkaloids
CrotalinIn Bloodagonistsanalogs & derivatives

Narrower (3)

dehydroretronecinemonocrotaline pyrroletrichodesmine

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2010
2010
The xanthine derivative KMUP‐1 inhibits models of pulmonary artery hypertension via increased NO and cGMP‐dependent inhibition of RhoA/Rho kinase
Background and purpose:  KMUP‐1 is known to increase cGMP, enhance endothelial nitric oxide synthase (eNOS) and suppress Rho… 
2006
2006
Prostacyclin therapy increases right ventricular capillarisation in a model for flow-associated pulmonary hypertension.
Highly Cited
2001
Highly Cited
2001
Experimental Heart Failure Beneficial Effects on Skeletal Muscle of the Angiotensin II Type 1 Receptor Blocker Irbesartan in
Luciano Dalla Libera, Barbara Ravara, Annalisa Angelini, Katia Rossini, Marco Sandri, Gaetano Thiene, Experimental Heart Failure… 
Highly Cited
1997
Highly Cited
1997
Nonspecific endothelin-receptor antagonist blunts monocrotaline-induced pulmonary hypertension in rats.
Endothelin-1 (ET-1), a potent vasoactive and mitogenic peptide, has been implicated in the pathogenesis of several forms of… 
Highly Cited
1996
Highly Cited
1996
Nebulized nitric oxide/nucleophile adduct reduces chronic pulmonary hypertension.
Highly Cited
1993
Highly Cited
1993
Role of 5-hydroxytryptamine in the progression of monocrotaline induced pulmonary hypertension in rats.
OBJECTIVE The aim was to clarify the role of serotonin (5-hydroxytryptamine, 5-HT) in monocrotaline induced pulmonary… 
Highly Cited
1990
Highly Cited
1990
Endothelin and 5-hydroxytryptamine on rat pulmonary artery in pulmonary hypertension.
Highly Cited
1982
Highly Cited
1982
Angiotensin converting enzyme activity and evolution of pulmonary vascular disease in rats with monocrotaline pulmonary hypertension.
We have investigated the role of angiotensin converting enzyme (ACE) in the development of pulmonary hypertension, right… 
Highly Cited
1981
Highly Cited
1981
Effect of pneumotoxicants on lactate dehydrogenase activity in airways of rats.
Highly Cited
1976
Highly Cited
1976
Neoplastic transformation in tissues of rats exposed to monocrotaline or dehydroretronecine.
Male Sprague-Dawley rats received sc injections biweekly of either the pyrrolizidine alkaloid monocrotaline or its metabolite… 
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