Monocrotaline

Known as: 20-Norcrotalanan-11,15-dione, 14,19-dihydro-12,13-dihydroxy-, (13alpha,14alpha)-, Monocrotaline [Chemical/Ingredient] 
A pyrrolizidine alkaloid and a toxic plant constituent that poisons livestock and humans through the ingestion of contaminated grains and other foods… (More)
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
OBJECTIVE MicroRNAs (miRNAs) are small noncoding RNAs that have the capacity to control protein production through binding "seed… (More)
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Highly Cited
2008
Highly Cited
2008
Proliferation of pulmonary arterial smooth muscle cells, endothelial dysfunction, oxidative stress, and inflammation promotes the… (More)
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Highly Cited
2007
Highly Cited
2007
The administration of mesenchymal stem cells (MSCs) has been proposed for the treatment of pulmonary hypertension. However, the… (More)
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Highly Cited
2005
Highly Cited
2005
Pulmonary arterial hypertension (PAH) is characterized by a progressive increase in pulmonary vascular resistance caused by… (More)
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Highly Cited
2005
Highly Cited
2005
Progression of pulmonary hypertension is associated with increased proliferation and migration of pulmonary vascular smooth… (More)
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Highly Cited
2004
Highly Cited
2004
Sildenafil, a phosphodiesterase 5 inhibitor, is currently under investigation for therapy of pulmonary hypertension. This study… (More)
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Highly Cited
2004
Highly Cited
2004
Primary pulmonary hypertension is a fatal disease characterized by endothelial dysfunction, hypercontraction and proliferation of… (More)
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Highly Cited
2001
Highly Cited
2001
BACKGROUND Pulmonary arterial hypertension is characterized by increased pulmonary vascular resistance secondary to a decrease in… (More)
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Highly Cited
1993
Highly Cited
1993
Endothelin-1 (ET-1) is known to have potent contractile and proliferative effects on vascular smooth muscle cells and is known to… (More)
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Highly Cited
1988
Highly Cited
1988
We used awake, unsedated rats with indwelling cardiovascular catheters to study the role of endothelial injury and increased… (More)
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