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cytochrome P-450 CYP1B1

Known as: Cytochrome P450 CYP1B1, Cytochrome P450, Family 1, Subfamily B, Polypeptide 1, Cytochrome P 450 CYP1B1 
A cytochrome P450 aryl hydrocarbon hydroxylase that has specificity for ESTROGENS which it converts into 4-hydroxy estrogens. CYP1B1 has been shown… 
National Institutes of Health

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Related topics

11 relations
CYP1B1 geneCYP3A7 protein, humanIn BloodProcess of secretion

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CYP1B1 protein, humanCyp1b1 protein, mouse

Papers overview

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Highly Cited
2018
Highly Cited
2018
Association between polymorphisms in estrogen metabolism genes and breast cancer development in Chinese women
Abstract We comprehensively identified polymorphisms in estrogen-metabolizing genes that may be associated with breast cancer… 
Highly Cited
2005
Highly Cited
2005
METABOLISM OF MELATONIN BY HUMAN CYTOCHROMES P450
In humans, the pineal hormone melatonin (MEL) is principally metabolized to 6-hydroxymelatonin (6-HMEL), which is further… 
Highly Cited
2002
Highly Cited
2002
The cancer preventative agent resveratrol is converted to the anticancer agent piceatannol by the cytochrome P450 enzyme CYP1B1
Resveratrol is a cancer preventative agent that is found in red wine. Piceatannol is a closely related stilbene that has… 
Highly Cited
2002
Highly Cited
2002
Digenic inheritance of early-onset glaucoma: CYP1B1, a potential modifier gene.
"Early-onset glaucoma" refers to genetically heterogeneous conditions for which glaucoma manifests at age 5-40 years and for… 
Highly Cited
2002
Highly Cited
2002
Arylhydrocarbon receptor-dependent induction of liver and lung cytochromes P450 1A1, 1A2, and 1B1 by polycyclic aromatic hydrocarbons and polychlorinated biphenyls in genetically engineered C57BL/6J…
Arylhydrocarbon receptor knock-out, AhR(-/-), mice have recently been shown to be rather resistant to benzo[a]pyrene (B[a]P… 
Review
2001
Review
2001
Regulation, function, and tissue-specific expression of cytochrome P450 CYP1B1.
Cytochrome P450 CYP1B1 is a relatively recently identified member of the CYP1 gene family. The purpose of this commentary is to… 
Highly Cited
2000
Highly Cited
2000
Bioflavonoids: selective substrates and inhibitors for cytochrome P450 CYP1A and CYP1B1.
Review
1998
Review
1998
Xenobiotic-metabolizing cytochrome P450 enzymes in the human feto-placental unit: role in intrauterine toxicity.
Practically all lipid-soluble xenobiotics enter the conceptus through placental transfer. Many xenobiotics, including a number of… 
Highly Cited
1995
Highly Cited
1995
Identification of a rat adrenal cytochrome P450 active in polycyclic hydrocarbon metabolism as rat CYP1B1. Demonstration of a unique tissue- specific pattern of hormonal and aryl hydrocarbon receptor…
Antibodies against a novel adrenocorticotropic hormone-inducible cytochrome P450 (P450RAP), responsible for polycyclic aromatic… 
Highly Cited
1994
Highly Cited
1994
Mouse cytochrome P-450EF, representative of a new 1B subfamily of cytochrome P-450s. Cloning, sequence determination, and tissue expression.
A novel benz[a]anthracene and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-inducible cytochrome P-450 (P450EF), which is very… 
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