cyclin-dependent protein kinase regulator activity

Known as: cyclin, cyclin-dependent protein serine/threonine kinase regulator activity 
Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through… (More)

Topic mentions per year

Topic mentions per year

1984-2018
020040019842018

Papers overview

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Highly Cited
2006
Highly Cited
2006
Cyclin D1 is a multifunctional protein that activates CDK4 and CDK6, titrates Cip/Kip CDK inhibitors to increase CDK2 activity… (More)
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Highly Cited
1999
Highly Cited
1999
The widely prevailing view that the cyclin-dependent kinase inhibitors (CKIs) are solely negative regulators of cyclin-dependent… (More)
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Highly Cited
1999
Highly Cited
1999
Mutations in the adenomatous polyposis coli (APC) tumour-suppressor gene occur in most human colon cancers. Loss of functional… (More)
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Highly Cited
1998
Highly Cited
1998
Recent studies have demonstrated the importance of E-cadherin, a homophilic cell-cell adhesion molecule, in contact inhibition of… (More)
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Highly Cited
1997
Highly Cited
1997
Cyclin-dependent kinases (cdk) play an essential role in the intracellular control of the cell division cycle (cdc). These… (More)
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Highly Cited
1997
Highly Cited
1997
p27Kip1, a cyclin-dependent kinase inhibitor, is recognized as a negative regulator of the cell cycle. In this paper, we report… (More)
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Highly Cited
1996
Highly Cited
1996
SUMMARY Disruption of the cyclin-dependent kinase-inhibitory domain of p27 enhances growth of mice. Growth is attributed to an… (More)
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Highly Cited
1995
Highly Cited
1995
The terminal differentiation of C2C12 skeletal muscle cells involves the activation of unique sets of genes and an irreversible… (More)
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Highly Cited
1994
Highly Cited
1994
D-type cyclin-dependent kinase activities have not so far been detected in mammalian cells. Lysis of rodent fibroblasts, mouse… (More)
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Highly Cited
1993
Highly Cited
1993
The cyclin-dependent kinase Cdk2 associates with cyclins A, D, and E and has been implicated in the control of the G1 to S phase… (More)
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