FAQ

cyclin-dependent protein kinase regulator activity

Known as: cyclin, cyclin-dependent protein serine/threonine kinase regulator activity 
Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through… (More)

Topic mentions per year

Topic mentions per year

1984-2018
020040019842018

Related topics

Related topics

5 relations
CyclinsPCNA geneProliferating Cell Nuclear Antigencyclin-dependent protein kinase activity
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Related mentions per year

Related mentions per year

1960-2018
1960198020002020
cyclin-dependent protein kinase regulator activity
Proliferating Cell Nuclear Antigen
Cyclins
PCNA gene
cyclin-dependent protein kinase activity
proliferating cell nuclear antigen activity

Papers overview

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Highly Cited
2006
Highly Cited
2006
Cyclin D1-dependent kinase activity in murine development and mammary tumorigenesis.
Cyclin D1 is a multifunctional protein that activates CDK4 and CDK6, titrates Cip/Kip CDK inhibitors to increase CDK2 activity… (More)
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Highly Cited
1999
Highly Cited
1999
The p21(Cip1) and p27(Kip1) CDK 'inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts.
The widely prevailing view that the cyclin-dependent kinase inhibitors (CKIs) are solely negative regulators of cyclin-dependent… (More)
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Highly Cited
1999
Highly Cited
1999
Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells.
Mutations in the adenomatous polyposis coli (APC) tumour-suppressor gene occur in most human colon cancers. Loss of functional… (More)
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Highly Cited
1998
Highly Cited
1998
E-Cadherin–dependent Growth Suppression is Mediated by the Cyclin-dependent Kinase Inhibitor p27KIP1
Recent studies have demonstrated the importance of E-cadherin, a homophilic cell-cell adhesion molecule, in contact inhibition of… (More)
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Highly Cited
1997
Highly Cited
1997
Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5.
Cyclin-dependent kinases (cdk) play an essential role in the intracellular control of the cell division cycle (cdc). These… (More)
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Highly Cited
1997
Highly Cited
1997
Promoting apoptosis: a novel activity associated with the cyclin-dependent kinase inhibitor p27.
p27Kip1, a cyclin-dependent kinase inhibitor, is recognized as a negative regulator of the cell cycle. In this paper, we report… (More)
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Highly Cited
1996
Highly Cited
1996
Enhanced Growth of Mice Lacking the Cyclin-Dependent Kinase Inhibitor Function of p27Kip1
SUMMARY Disruption of the cyclin-dependent kinase-inhibitory domain of p27 enhances growth of mice. Growth is attributed to an… (More)
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Highly Cited
1995
Highly Cited
1995
MyoD-induced expression of p21 inhibits cyclin-dependent kinase activity upon myocyte terminal differentiation.
The terminal differentiation of C2C12 skeletal muscle cells involves the activation of unique sets of genes and an irreversible… (More)
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Highly Cited
1994
Highly Cited
1994
D-type cyclin-dependent kinase activity in mammalian cells.
D-type cyclin-dependent kinase activities have not so far been detected in mammalian cells. Lysis of rodent fibroblasts, mouse… (More)
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Highly Cited
1993
Highly Cited
1993
The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases.
The cyclin-dependent kinase Cdk2 associates with cyclins A, D, and E and has been implicated in the control of the G1 to S phase… (More)
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