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Cyclins

Known as: Cyclin, Cyclins [Chemical/Ingredient] 
A large family of regulatory proteins that function as accessory subunits to a variety of CYCLIN-DEPENDENT KINASES. They generally function as ENZYME… 
National Institutes of Health

Related topics

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Narrower (15)

CCNE2 protein, humanCLN1 protein, Candida albicansCables1 protein, mouseCcnl1 protein, rat
CCNJ geneCNNM1 geneCNNM2 geneCNNM3 gene

Broader (1)

Cell Cycle Proteins

Papers overview

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2003
2003
p15 INK4b , p14 ARF , and p16 INK4a Inactivation in Sporadic and Neurofibromatosis Type 1-related Malignant Peripheral Nerve Sheath Tumors 1
Purpose : Malignant peripheral nerve sheath tumor (MPNST) can arise sporadically or in association with neurofibromatosis type 1… 
2002
2002
Retinoic acid – induced cell cycle arrest of human myeloid cell lines is associated with sequential down-regulation of c-Myc and cyclin E and posttranscriptional up-regulation of p 27 Kip 1
Alltrans retinoic acid (ATRA) is a potential therapeutic agent for the treatment of hematopoietic malignancies, because of its… 
2001
2001
Sp 1 Plays a Critical Role in the Transcriptional Activation of the Human Cyclin-dependent Kinase Inhibitor p 21 WAF 1 / Cip 1 Gene by the p 53 Tumor Suppressor Protein *
In the present study we present evidence for the critical role of Sp1 in the mechanism of transactivation of the human cell cycle… 
2001
2001
In vivo metabolism of 2,6,9-trisubstituted purine-derived cyclin-dependent kinase inhibitor bohemine in mice: glucosidation as the principal metabolic route.
Synthetic cyclin-dependent kinase inhibitors have recently been referred to as effective antiproliferative agents. This study was… 
1999
1999
Distinct Regulation of p 53 and p 73 Activity by Adenovirus E 1 A , E 1 B , and E 4 orf 6 Proteins
WILMA T. STEEGENGA,* AVI SHVARTS, NICOLE RITECO, JOHANNES L. BOS, AND AART G. JOCHEMSEN Laboratory for Physiological Chemistry… 
1999
1999
Overexpression of D-type cyclins, E2F-1, SV40 large T antigen and HPV16 E7 rescue cell cycle arrest of tsBN462 cells caused by the CCG1/TAFII250 mutation
tsBN462 cells, which have a point mutation in CCG1/TAFII250, a component of TFIID complex, arrest in G1 at the nonpermissive… 
1998
1998
Immunohistochemical study of cyclins D and E and cyclin dependent kinase (cdk) 2 and 4 in human endometrial carcinoma.
We studied the immunolocalization of cyclins D1 and E and their corresponding partner cyclin dependent kinases (cdk), cdk4 and… 
1998
1998
Structure-based inhibitor design for CDK2, a cell cycle controlling protein kinase
Abstract 
1996
1996
Intestinal cell cycle regulations. Interactions of cyclin D1, Cdk4, and p21Cip1.
OBJECTIVE The p21Cip1 protein is a potent stoichiometric inhibitor of cyclin-dependent kinase activity, and p21Cip1 mRNA… 
1993
1993
Molecular and Cell Biology of the Plant Cell Cycle
The control over entry into mitosis in many different organisms involves the activity of a key enzyme, p34cdc2 which is a serine…