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Cyclins

Known as: Cyclin, Cyclins [Chemical/Ingredient] 
A large family of regulatory proteins that function as accessory subunits to a variety of CYCLIN-DEPENDENT KINASES. They generally function as ENZYME… 
National Institutes of Health

Related topics

Related topics

38 relations

Narrower (15)

CCNE2 protein, humanCLN1 protein, Candida albicansCables1 protein, mouseCcnl1 protein, rat
CCNJ geneCNNM1 geneCNNM2 geneCNNM3 gene

Broader (1)

Cell Cycle Proteins

Papers overview

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Highly Cited
2004
Highly Cited
2004
Cyclin-dependent kinases regulate the antiproliferative function of Smads
Transforming growth factor-β (TGF-β) potently inhibits cell cycle progression at the G1 phase. Smad3 has a key function in… 
Review
2002
Review
2002
Regulation of cyclin-Cdk activity in mammalian cells
Abstract. Cell cycle progression is driven by the coordinated regulation of the activities of cyclin-dependent kinases (Cdks). Of… 
Highly Cited
1997
Highly Cited
1997
Phosphorylation‐dependent degradation of the cyclin‐dependent kinase inhibitor p27Kip1
The p27Kip1 protein associates with G1‐specific cyclin–CDK complexes and inhibits their catalytic activity. p27Kip1 is regulated… 
Highly Cited
1996
Highly Cited
1996
In vivo ubiquitination and proteasome-mediated degradation of p53(1).
The levels of the tumor suppressor protein p53 are generally quite low in normal cells, due in part to its rapid turnover… 
Highly Cited
1996
Highly Cited
1996
Control of root growth and development by cyclin expression
ROOT development is plastic, with post-embryonic organogenesis being mediated by meristems1. Although cell division is intrinsic… 
Highly Cited
1995
Highly Cited
1995
Inhibition of cyclin-dependent kinases by p21.
p21Cip1 is a cyclin-dependent kinase (Cdk) inhibitor that is transcriptionally activated by p53 in response to DNA damage. We… 
Highly Cited
1995
Highly Cited
1995
Different roles for cyclins D1 and E in regulation of the G1-to-S transition
Ectopic expression of cyclins D1 and E was previously shown to accelerate the G1/S-phase transition, indicating that both classes… 
Highly Cited
1993
Highly Cited
1993
Cyclin-dependent regulation of G1 in mammalian fibroblasts.
Eukaryotic cells become committed to proliferate during the G1 phase of the cell cycle. In budding yeast, commitment occurs when… 
Highly Cited
1992
Highly Cited
1992
Association of human cyclin E with a periodic G1-S phase protein kinase.
G1 cyclins control the G1 to S phase transition in the budding yeast, Saccharomyces cerevisiae. Cyclin E was discovered in the… 
Highly Cited
1990
Highly Cited
1990
Human cyclin A is adenovirus E1A-associated protein p60 and behaves differently from cyclin B
CYCLINS are proteins synthesized during each cell cycle and abruptly destroyed in each mitosis1–5. Cyclins have been implicated… 
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