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Entry into, progression through, and exit from the G1 phase of the mammalian cell cycle in response to extracellular mitogenic… Expand I discuss advances in the cell cycle in the 21 years since cyclin was discovered. The surprising redundancy amongst the classical… Expand The activities of cyclin D-dependent kinases serve to integrate extracellular signaling during G1 phase with the cell-cycle… Expand D-type cyclins couple extracellular signals to the biochemical machinery that governs progression through G1 phase of the… Expand All eukaryotic cells possess similar mechanisms to regulate the progression of the cell cycle. However, higher eukaryotes have… Expand The cyclin-dependent kinase Cdk2 associates with cyclins A, D, and E and has been implicated in the control of the G1 to S phase… Expand DEREGULATION of cell proliferation is a hallmark of neoplastic transformation. Alteration in growth control pathways must… Expand THE division cycle of eukaryotic cells is regulated by a family of protein kinases known as the cyclin-dependent kinases (CDKs)1… Expand Cyclin degradation is the key step governing exit from mitosis and progress into the next cell cycle. When a region in the N… Expand Identification of the cellular proteins whose expression is regulated during the cell cycle in normal cells is essential for… Expand