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crizotinib

Known as: (R)-Crizotinib, 2-Pyridinamine, 3-((1R)-1-(2,6-Dichloro-3-Fluorophenyl)Ethoxy)-5-(1-(4-Piperidinyl)-1H-Pyrazol-4-yl)-, (R)-3-(1-(2,6-Dichloro-3-Fluorophenyl)Ethoxy)-5-(1-(Piperidin-4-Yl)-1h-Pyrazol-4-Yl)Pyridin-2-Amine 
An orally available aminopyridine-based inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) and the c-Met/hepatocyte growth… Expand
National Institutes of Health

Papers overview

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Review
2018
Review
2018
The ALK gene encodes a transmembrane tyrosine kinase receptor. ALK is physiologically expressed in the nervous system during… Expand
Review
2018
Review
2018
Background Brigatinib, a next‐generation anaplastic lymphoma kinase (ALK) inhibitor, has robust efficacy in patients with ALK… Expand
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Highly Cited
2014
Highly Cited
2014
BACKGROUND Chromosomal rearrangements of the gene encoding ROS1 proto-oncogene receptor tyrosine kinase (ROS1) define a distinct… Expand
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Highly Cited
2014
Highly Cited
2014
UNLABELLED Non-small cell lung cancers (NSCLC) harboring anaplastic lymphoma kinase (ALK) gene rearrangements invariably develop… Expand
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Highly Cited
2013
Highly Cited
2013
BACKGROUND In single-group studies, chromosomal rearrangements of the anaplastic lymphoma kinase gene (ALK) have been associated… Expand
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Highly Cited
2012
Highly Cited
2012
Multiple mechanisms of crizotinib resistance were identified in lung cancer patients including new secondary ALK mutations and… Expand
Highly Cited
2012
Highly Cited
2012
Purpose: Patients with anaplastic lymphoma kinase (ALK) gene rearrangements often manifest dramatic responses to crizotinib, a… Expand
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Highly Cited
2012
Highly Cited
2012
BACKGROUND ALK fusion genes occur in a subset of non-small-cell lung cancers (NSCLCs). We assessed the tolerability and activity… Expand
Highly Cited
2011
Highly Cited
2011
BACKGROUND ALK gene rearrangement defines a new molecular subtype of non-small-cell lung cancer (NSCLC). In a recent phase 1… Expand
Highly Cited
2010
Highly Cited
2010
Inflammatory myofibroblastic tumor (IMT) is a distinctive mesenchymal neoplasm characterized by a spindle-cell proliferation with… Expand
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