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clofilium

Known as: Benzenebutanaminium, 4-Chloro-N,N-Diethyl-N-Heptyl, (4-(P-Chlorophenyl)Butyl)Diethylheptylammonium, Benzenebutanaminium, 4-chloro-N,N-diethyl-N-heptyl- 
 
National Institutes of Health

Related topics

Related topics

6 relations

Broader (3)

Anti-Arrhythmia AgentsPotassium Channel BlockersQuaternary Ammonium Compounds
Clofilium Tosylateclofilium phosphate

Narrower (1)

fluoroclofilium

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2006
Highly Cited
2006
New insights about HERG blockade obtained from protein modeling, potential energy mapping, and docking studies.
We created a homology model of the homo-tetrameric pore domain of HERG using the crystal structure of the bacterial potassium… Expand
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Highly Cited
2004
Highly Cited
2004
Structural Determinants of HERG Channel Block by Clofilium and Ibutilide
Block of human ether-a-go-go related gene (HERG) K+ channels by a variety of medications has been linked to acquired long QT… Expand
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Highly Cited
2004
Highly Cited
2004
Electrophysiological properties of human mesenchymal stem cells
Human mesenchymal stem cells (hMSC) have gained considerable interest due to their potential use for cell replacement therapy and… Expand
Highly Cited
1999
Highly Cited
1999
Role of the Outward Delayed Rectifier K+ Current in Ceramide‐Induced Caspase Activation and Apoptosis in Cultured Cortical Neurons
Abstract : We studied the novel hypothesis that an upmodulation of channels for outward delayed rectifier K+ current (Iκ) plays a… Expand
Highly Cited
1998
Highly Cited
1998
KN-93, an inhibitor of multifunctional Ca++/calmodulin-dependent protein kinase, decreases early afterdepolarizations in rabbit heart.
The multifunctional Ca++/calmodulin-dependent protein kinase II (CaM kinase) mediates Ca++-induced augmentation of L-type Ca… Expand
Highly Cited
1998
Highly Cited
1998
Killing of Chlamydia trachomatis by Novel Antimicrobial Lipids Adapted from Compounds in Human Breast Milk
ABSTRACT The development of new methods for prevention of sexually transmitted Chlamydia trachomatis infection is a top public… Expand
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Highly Cited
1997
Highly Cited
1997
KvLQT1, a voltage-gated potassium channel responsible for human cardiac arrhythmias.
The clinical features of long QT syndrome result from episodic life-threatening cardiac arrhythmias, specifically the polymorphic… Expand
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Highly Cited
1993
Highly Cited
1993
Comparative Assessment of Ibutilide, D‐Sotalol, Clofilium, E‐4031, and UK‐68, 798 in a Rabbit Model of Proarrhythmia
Summary Class III agents have been associated with development of a polymorphic ventricular tachycardia (PVT) known as torsades… Expand
Highly Cited
1990
Highly Cited
1990
QTU‐Prolongation and Torsades de Pointes Induced by Putative Class III Antiarrhythmic Agents in the Rabbit: Etiology and Interventions
When low doses of clofilium were administered to conscious rabbits, ventricular tachyarrhythmia (VT) with features typical of… Expand
Highly Cited
1988
Highly Cited
1988
Block of heart potassium channels by clofilium and its tertiary analogs: relationship between drug structure and type of channel blocked.
The whole-cell arrangement of the patch clamp was used to study delayed rectifier and inward rectifier K channels in isolated… Expand
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