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clofilium

Known as: Benzenebutanaminium, 4-Chloro-N,N-Diethyl-N-Heptyl, (4-(P-Chlorophenyl)Butyl)Diethylheptylammonium, Benzenebutanaminium, 4-chloro-N,N-diethyl-N-heptyl- 
National Institutes of Health

Related topics

Related topics

6 relations

Broader (3)

Anti-Arrhythmia AgentsPotassium Channel BlockersQuaternary Ammonium Compounds
Clofilium Tosylateclofilium phosphate

Narrower (1)

fluoroclofilium

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2006
Highly Cited
2006
New insights about HERG blockade obtained from protein modeling, potential energy mapping, and docking studies.
Highly Cited
2006
Highly Cited
2006
RSD1235 blocks late INa and suppresses early afterdepolarizations and torsades de pointes induced by class III agents.
Highly Cited
2004
Highly Cited
2004
Structural Determinants of HERG Channel Block by Clofilium and Ibutilide
Block of human ether-a-go-go related gene (HERG) K+ channels by a variety of medications has been linked to acquired long QT… 
Highly Cited
2001
Highly Cited
2001
[3H]dofetilide binding to HERG transfected membranes: a potential high throughput preclinical screen.
Highly Cited
1998
Highly Cited
1998
KN-93, an inhibitor of multifunctional Ca++/calmodulin-dependent protein kinase, decreases early afterdepolarizations in rabbit heart.
The multifunctional Ca++/calmodulin-dependent protein kinase II (CaM kinase) mediates Ca++-induced augmentation of L-type Ca… 
Highly Cited
1995
Highly Cited
1995
Induction of endogenous channels by high levels of heterologous membrane proteins in Xenopus oocytes.
Highly Cited
1993
Highly Cited
1993
Comparative Assessment of Ibutilide, D‐Sotalol, Clofilium, E‐4031, and UK‐68, 798 in a Rabbit Model of Proarrhythmia
Summary Class III agents have been associated with development of a polymorphic ventricular tachycardia (PVT) known as torsades… 
Highly Cited
1992
Highly Cited
1992
Cloning, functional expression, and regulation of two K+ channels in human T lymphocytes.
Highly Cited
1988
Highly Cited
1988
Block of heart potassium channels by clofilium and its tertiary analogs: relationship between drug structure and type of channel blocked.
The whole-cell arrangement of the patch clamp was used to study delayed rectifier and inward rectifier K channels in isolated… 
Highly Cited
1979
Highly Cited
1979
Clofilum--a new antifibrillatory agent that selectively increases cellular refractoriness.
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