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clofilium

Known as: Benzenebutanaminium, 4-Chloro-N,N-Diethyl-N-Heptyl, (4-(P-Chlorophenyl)Butyl)Diethylheptylammonium, Benzenebutanaminium, 4-chloro-N,N-diethyl-N-heptyl- 
 
National Institutes of Health

Related topics

Related topics

6 relations

Broader (3)

Anti-Arrhythmia AgentsPotassium Channel BlockersQuaternary Ammonium Compounds
Clofilium Tosylateclofilium phosphate

Narrower (1)

fluoroclofilium

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2006
2006
Drug binding interactions in the inner cavity of HERG channels: molecular insights from structure-activity relationships of clofilium and ibutilide analogs.
Block of human ether-a-go-go related gene (hERG) K(+) channels by otherwise useful drugs is the most common cause of long QT… Expand
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Highly Cited
2004
Highly Cited
2004
Structural determinants of HERG channel block by clofilium and ibutilide.
Block of human ether-a-go-go related gene (HERG) K(+) channels by a variety of medications has been linked to acquired long QT… Expand
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Highly Cited
2004
Highly Cited
2004
Electrophysiological properties of human mesenchymal stem cells.
Human mesenchymal stem cells (hMSC) have gained considerable interest due to their potential use for cell replacement therapy and… Expand
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Highly Cited
2003
Highly Cited
2003
Potassium channel blockers attenuate hypoxia- and ischemia-induced neuronal death in vitro and in vivo.
BACKGROUND AND PURPOSE In light of recent evidence suggesting that an upregulation of K+ efflux mediated by outward delayed… Expand
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Highly Cited
1999
Highly Cited
1999
Role of the outward delayed rectifier K+ current in ceramide-induced caspase activation and apoptosis in cultured cortical neurons.
We studied the novel hypothesis that an up-modulation of channels for outward delayed rectifier K+ current (I(K)) plays a key… Expand
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Highly Cited
1998
Highly Cited
1998
KN-93, an inhibitor of multifunctional Ca++/calmodulin-dependent protein kinase, decreases early afterdepolarizations in rabbit heart.
The multifunctional Ca++/calmodulin-dependent protein kinase II (CaM kinase) mediates Ca++-induced augmentation of L-type Ca… Expand
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1998
1998
Killing of Chlamydia trachomatis by novel antimicrobial lipids adapted from compounds in human breast milk.
The development of new methods for prevention of sexually transmitted Chlamydia trachomatis infection is a top public health… Expand
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Highly Cited
1997
Highly Cited
1997
KvLQT1, a voltage-gated potassium channel responsible for human cardiac arrhythmias.
The clinical features of long QT syndrome result from episodic life-threatening cardiac arrhythmias, specifically the polymorphic… Expand
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1993
1993
Comparative assessment of ibutilide, D-sotalol, clofilium, E-4031, and UK-68,798 in a rabbit model of proarrhythmia.
Class III agents have been associated with development of a polymorphic ventricular tachycardia (PVT) known as torsades de… Expand
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1988
1988
Block of heart potassium channels by clofilium and its tertiary analogs: relationship between drug structure and type of channel blocked.
The whole-cell arrangement of the patch clamp was used to study delayed rectifier and inward rectifier K channels in isolated… Expand
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