clofilium

K201 (JTV519) is a 1,4-benzothiazepine derivative that exhibits a strong cardioprotective action and acts as a multiple-channel… (More)

1 We investigated the inhibition of hEAG1 potassium channels, expressed in mammalian cells and Xenopus oocytes, by several… (More)

1. This study was designed to compare the proarrhythmic activity of the antimalarial drug, halofantrine and the antihistamine… (More)

Torsades de pointes is a potentially life-threatening form of polymorphic ventricular tachyarrhythmia typically seen in the… (More)

The class III antiarrhythmic drug clofilium is known to block diverse delayed rectifier K+ channels at micromolar concentrations… (More)

INTRODUCTION The roles for L-type calcium current and Na-Ca exchange in early afterdepolarizations (EADs) attending d,l-sotalol… (More)

The effect of clofilium on potassium conductance was studied in excised membrane patches from Chinese hamster ovary cells stably… (More)

Class III agents have been associated with development of a polymorphic ventricular tachycardia (PVT) known as torsades de… (More)

To determine whether ischaemic tissue is more sensitive than normal tissue to class III anti-arrhythmic agents, we studied the… (More)

The whole-cell arrangement of the patch clamp was used to study delayed rectifier and inward rectifier K channels in isolated… (More)