Skip to search formSkip to main contentSkip to account menu

clofilium

Known as: Benzenebutanaminium, 4-Chloro-N,N-Diethyl-N-Heptyl, (4-(P-Chlorophenyl)Butyl)Diethylheptylammonium, Benzenebutanaminium, 4-chloro-N,N-diethyl-N-heptyl- 
National Institutes of Health

Related topics

Related topics

6 relations

Broader (3)

Anti-Arrhythmia AgentsPotassium Channel BlockersQuaternary Ammonium Compounds
Clofilium Tosylateclofilium phosphate

Narrower (1)

fluoroclofilium

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2012
2012
hERG ion channel pharmacology: cell membrane liposomes in porous-supported lipid bilayers compared with whole-cell patch-clamping
The purpose of this study was to obtain functional hERG ion channel protein for use in a non-cell-based ion channel assay. hERG… 
2007
2007
K201, a multi-channel blocker, inhibits clofilium-induced torsades de pointes and attenuates an increase in repolarization
1999
1999
Block of voltage-gated potassium channels by acidic pH and Class III antiarrhythmic agents
The goal of experiments performed in this dissertation was to determine molecular mechanisms underlying cardiac action potential… 
1999
1999
Ion channels in the human myometrium.
The uterine smooth muscle, or the myornetrium, provides the powerful rhythmic contractions required for parturition. Myometrial… 
1995
1995
CLOFILIUM, A POTENT BLOCKER OF SODIUM AND CALCIUM CHANNELS IN GUINEA-PIG VENTRICULAR MYOCYTES
The unsatisfactory results of clinical trials with class-Ⅰ antiarrhythmic drugs have prompted a renaissance of interest in… 
1990
1990
Effects of MDL 11,939 on Action Potential and Contractile Force in Cardiac Tissues: A Comparison with Bretylium, Clofilium, and Sotalol
Summary: The effect of MDL 11,939 hydrochloride [α-phenyl-1-(2-phenylethyl)-4-piperidinemethanol HCl], a novel antiarrhythmic… 
Review
1989
Review
1989
Clofilium and Other Class III Agents
If the wavelength of a reentrant impulse exceeds the path length of the circuit, reentry cannot be maintained (see Cranefield… 
1986
1986
Effects of antiarrhythmic agents on isoproterenol-induced ventricular fibrillation in heavy rats: a possible model of sudden cardiac death.
Heavy male Sprague-Dawley rats die of ventricular fibrillation within 2 to 3 h after isoproterenol administration. Thus, the… 
1984
1984
Antiarrhythmic drugs: Verapamil, Clofilium
1981
1981
Cellular Electrophysiology of Clofilium, a New Antifibrillatory Agent, in Normal and Ischemic Canine Purkinje Fibers
Summary Intracellular electrophysiological studies were performed on isolated canine cardiac tissues to investigate further the…