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clofilium
Known as:
Benzenebutanaminium, 4-Chloro-N,N-Diethyl-N-Heptyl
, (4-(P-Chlorophenyl)Butyl)Diethylheptylammonium
, Benzenebutanaminium, 4-chloro-N,N-diethyl-N-heptyl-
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National Institutes of Health
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Related topics
Related topics
6 relations
Broader (3)
Anti-Arrhythmia Agents
Potassium Channel Blockers
Quaternary Ammonium Compounds
Clofilium Tosylate
clofilium phosphate
Narrower (1)
fluoroclofilium
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2006
Highly Cited
2006
New insights about HERG blockade obtained from protein modeling, potential energy mapping, and docking studies.
R. Farid
,
T. Day
,
R. Friesner
,
R. Pearlstein
Bioorganic & medicinal chemistry
2006
Corpus ID: 18090070
Highly Cited
2006
Highly Cited
2006
RSD1235 blocks late INa and suppresses early afterdepolarizations and torsades de pointes induced by class III agents.
P. Orth
,
J. C. Hesketh
,
+5 authors
D. Fedida
Cardiovascular research
2006
Corpus ID: 391765
Highly Cited
2004
Highly Cited
2004
Structural Determinants of HERG Channel Block by Clofilium and Ibutilide
M. Perry
,
M. D. de Groot
,
+4 authors
J. Mitcheson
Molecular Pharmacology
2004
Corpus ID: 7974939
Block of human ether-a-go-go related gene (HERG) K+ channels by a variety of medications has been linked to acquired long QT…
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Highly Cited
2001
Highly Cited
2001
[3H]dofetilide binding to HERG transfected membranes: a potential high throughput preclinical screen.
K. Finlayson
,
L. Turnbull
,
C. January
,
J. Sharkey
,
J. Kelly
European journal of pharmacology
2001
Corpus ID: 37010941
Highly Cited
1998
Highly Cited
1998
KN-93, an inhibitor of multifunctional Ca++/calmodulin-dependent protein kinase, decreases early afterdepolarizations in rabbit heart.
M. Anderson
,
A. Braun
,
Y. Wu
,
T. Lu
,
H. Schulman
,
R. Sung
The Journal of pharmacology and experimental…
1998
Corpus ID: 22204347
The multifunctional Ca++/calmodulin-dependent protein kinase II (CaM kinase) mediates Ca++-induced augmentation of L-type Ca…
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Highly Cited
1995
Highly Cited
1995
Induction of endogenous channels by high levels of heterologous membrane proteins in Xenopus oocytes.
T. Tzounopoulos
,
J. Maylie
,
J. Adelman
Biophysical journal
1995
Corpus ID: 223387
Highly Cited
1993
Highly Cited
1993
Comparative Assessment of Ibutilide, D‐Sotalol, Clofilium, E‐4031, and UK‐68, 798 in a Rabbit Model of Proarrhythmia
L. V. Buchanan
,
G. Kabell
,
M. Brunden
,
J. K. Gibson
Journal of cardiovascular pharmacology
1993
Corpus ID: 22895631
Summary Class III agents have been associated with development of a polymorphic ventricular tachycardia (PVT) known as torsades…
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Highly Cited
1992
Highly Cited
1992
Cloning, functional expression, and regulation of two K+ channels in human T lymphocytes.
B. Attali
,
G. Romey
,
+6 authors
M. Lazdunski
The Journal of biological chemistry
1992
Corpus ID: 26213342
Highly Cited
1988
Highly Cited
1988
Block of heart potassium channels by clofilium and its tertiary analogs: relationship between drug structure and type of channel blocked.
J. P. Arena
,
R. Kass
Molecular pharmacology
1988
Corpus ID: 37837445
The whole-cell arrangement of the patch clamp was used to study delayed rectifier and inward rectifier K channels in isolated…
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Highly Cited
1979
Highly Cited
1979
Clofilum--a new antifibrillatory agent that selectively increases cellular refractoriness.
M. I. Steinberg
,
B. Molloy
Life sciences
1979
Corpus ID: 45612152
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