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clofilium

Known as: Benzenebutanaminium, 4-Chloro-N,N-Diethyl-N-Heptyl, (4-(P-Chlorophenyl)Butyl)Diethylheptylammonium, Benzenebutanaminium, 4-chloro-N,N-diethyl-N-heptyl- 
National Institutes of Health

Related topics

Related topics

6 relations

Broader (3)

Anti-Arrhythmia AgentsPotassium Channel BlockersQuaternary Ammonium Compounds
Clofilium Tosylateclofilium phosphate

Narrower (1)

fluoroclofilium

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2002
Highly Cited
2002
Proarrhythmic potential of halofantrine, terfenadine and clofilium in a modified in vivo model of torsade de pointes
This study was designed to compare the proarrhythmic activity of the antimalarial drug, halofantrine and the antihistamine… 
Highly Cited
2002
Highly Cited
2002
Oxidant stress stimulates anion secretion from the human airway epithelial cell line calu‐3: implications for cystic fibrosis lung disease
Exposure to reactive oxygen species (ROS) is associated with tissue damage in the lung and may be a common element in the… 
Review
2001
Review
2001
Intracellular signalling involved in activation of the volume-sensitive K+ current in Ehrlich ascites tumour cells.
1998
1998
Clofilium in the isolated perfused rabbit heart: A new model to study proarrhythmia induced by class III antiarrhythmic drugs
AbstractObjective: The clinical usefulness of class III antiarrhythmic drugs for the treatment of tachyarrhythmias is limited by… 
1995
1995
Antiarrhythmic and bradycardic drugs inhibit currents of cloned K+ channels, KV1.2 and KV1.4.
Highly Cited
1993
Highly Cited
1993
Comparative Assessment of Ibutilide, D‐Sotalol, Clofilium, E‐4031, and UK‐68, 798 in a Rabbit Model of Proarrhythmia
Summary Class III agents have been associated with development of a polymorphic ventricular tachycardia (PVT) known as torsades… 
1991
1991
Oral clofilium produces sustained lowering of defibrillation energy requirements in a canine model.
The effect of long-term oral administration of antiarrhythmic drugs on defibrillation energy requirements is not well understood… 
Highly Cited
1991
Highly Cited
1991
Cloning, expression, pharmacology and regulation of a delayed rectifier K+ channel in mouse heart.
Neonatal mouse cardiac poly(A)+ mRNA microinjection into Xenopus oocytes directed the expression of a delayed rectifier K… 
1991
1991
Cellular Electrophysiological Effects of the Class III Antiarrhythmic Agents Sematilide and Clofilium on Rabbit Atrial Tissues
Sematilide (N-[2-(diethylamino)ethyl]-4-[(methylsulfonyl)amino]benzamide HCl) is a new class III antiarrhythmic agent that has… 
1984
1984
Dose‐ranging studies of clofilium, an antiarrhythmic quaternary ammonium
Clofilium, a new quaternary ammonium antiarrhythmic without apparent ganglion‐blocking effect, was evaluated in 25 patients, 22… 
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