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Abstract Several therapeutic agents and industrial chemicals induce liver tumors in rodents through the activation of the… Expand The worldwide prevalence of obesity and related metabolic disorders is rising rapidly, increasing the burden on our healthcare… Expand Fibrates, such as ciprofibrate, fenofibrate, and clofibrate, are peroxisome proliferator-activated receptor-alpha (PPARalpha… Expand Genetically modified mice have been extensively used for analyzing the molecular events that occur during tumor development. In… Expand Fibrates and glitazones are two classes of drugs currently used in the treatment of dyslipidemia and insulin resistance (IR… Expand BACKGROUND
Exaggerated postprandial lipemia (PPL) is a factor in atherogenesis, involving endothelial dysfunction and enhanced… Expand OBJECTIVE
To provide a direct comparison of agents that raise plasma levels of high-density lipoprotein cholesterol (HDL-C) to… Expand Peroxisome proliferators are postulated to elicit predictable pleiotropic responses in the liver by activating a peroxisome… Expand Fenofibrate is a lipid-regulating drug which is structurally related to other fibric acid derivatives, such as clofibrate. At the… Expand The structurally diverse peroxisome proliferators ciprofibrate, clofibrate, and bis(2-ethylhexyl) phthalate [(EtHx)2 greater than… Expand