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Investigations of biological programs that are controlled by gene transcription have mainly studied the regulation of… Expand I. Introduction II. Molecular Aspects A. PPAR isotypes: identity, genomic organization and chromosomal localization B. DNA… Expand The peroxisome proliferator-activated receptor-γ (PPAR-γ) is a member of the nuclear receptor superfamily of ligand-dependent… Expand The peroxisome proliferator-activated receptor-γ (PPAR-γ) is a ligand-dependent transcription factor that is important in… Expand Prostaglandins (PGs) of the J2 series form in vivo and exert effects on a variety of biological processes. While most of PGs… Expand To gain insight into the function of peroxisome proliferator-activated receptor (PPAR) isoforms in rodents, we disrupted the… Expand Thiazolidinedione derivatives are antidiabetic agents that increase the insulin sensitivity of target tissues in animal models of… Expand To gain insight into the function of peroxisome proliferator-activated receptor (PPAR) isoforms in mammals, we have cloned and… Expand PEROXISOMES are cytoplasmic organelles which are important in mammals in modulation of lipid homeostasis, including the… Expand We have cloned a member of the steroid hormone receptor superfamily of ligand-activated transcription factors. The receptor… Expand