• Publications
  • Influence
5-Aminoimidazole-4-carboxamide-1-β-D-ribofuranoside Inhibits Cancer Cell Proliferation in Vitro and in Vivo via AMP-activated Protein Kinase*
Results indicate that AICAR can be utilized as a therapeutic drug to inhibit cancer, and AMPK can be a potential target for treatment of various cancers independent of the functional tumor suppressor gene, LKB. Expand
Lovastatin and phenylacetate inhibit the induction of nitric oxide synthase and cytokines in rat primary astrocytes, microglia, and macrophages.
A novel role of the mevalonate pathway is delineated in controlling the expression of iNOS and different cytokines in rat astrocytes, microglia, and macrophages that may be important in developing therapeutics against cytokine- and NO-mediated neurodegenerative diseases. Expand
5-Aminoimidazole-4-Carboxamide-1-β-4-Ribofuranoside Inhibits Proinflammatory Response in Glial Cells: A Possible Role of AMP-Activated Protein Kinase
5-amino-4-imidazole carboxamide riboside (AICAR) inhibited lipopolysaccharide (LPS)-induced expression of proinflammatory cytokines and inducible nitric oxide synthase in primary rat astrocytes, microglia, and peritoneal macrophages and suggests that AICAR may be of therapeutic value in treating inflammatory diseases. Expand
Statin inhibits kainic acid-induced seizure and associated inflammation and hippocampal cell death
Investigation of anti-excitotoxic and anti-seizure effects of statins by using kainic acid-rat seizure model suggests a potential for use of statin treatment in modulation of seizures and other neurological diseases associated with excitotoxicity. Expand
Pharmacological strategies for the regulation of inducible nitric oxide synthase: Neurodegenerative versus neuroprotective mechanisms
This review aims to provide basic insights into the NOS family of enzymes with special emphasis of the role of iNOS in the CNS, and an exhaustive compilation of the prevalent strategies being tested for the therapeutic modulation ofiNOS and NO production. Expand
N‐acetylcysteine prevents endotoxin‐induced degeneration of oligodendrocyte progenitors and hypomyelination in developing rat brain
The hypothesis that NAC may provide neuroprotection and attenuate the degeneration of OPCs against LPS evoked inflammatory response and white matter injury in developing rat brain is supported. Expand
Hepatocellular and Hepatic Peroxisomal Alterations in Mice with a Disrupted Peroxisomal Fatty Acyl-coenzyme A Oxidase Gene*
  • C. Fan, J. Pan, +8 authors J. Reddy
  • Medicine, Biology
  • The Journal of Biological Chemistry
  • 4 October 1996
Observations demonstrate links among peroxisomal β-oxidation, development of severe microvesicular fatty liver,peroxisome assembly, cell death, and cell proliferation in liver. Expand
Potential Targets of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitor for Multiple Sclerosis Therapy
Observations indicate that the anti-inflammatory effects of lovastatin are mediated via T cells as well as APCs, because it modulates the polarization patterns of naive T cell activation in an APC-independent system. Expand
Amelioration of experimental allergic encephalomyelitis in Lewis rats by lovastatin
Administration of lovastatin inhibited the expression of iNOS, TNF-alpha and IFN-gamma in the CNS of EAE rats and improved the clinical signs of Eae suggesting that this compound may have therapeutic potential in the treatment of neuroinflammatory diseases like MS. Expand
Lovastatin treatment decreases mononuclear cell infiltration into the CNS of Lewis rats with experimental allergic encephalomyelitis
The results indicate that Lovastatin treatment prevents infiltration by mononuclear cells into the CNS of rats induced for EAE, thereby lessening the histological changes and clinical signs and thus ameliorating the disease. Expand