caspase activity

OBSOLETE. Catalysis of the hydrolysis of a peptide bond on the carboxyl side of an aspartate residue. [PMID:10872455]
National Institutes of Health

Papers overview

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Highly Cited
2006
Highly Cited
2006
Pruning is important for sculpting neural circuits, as it removes excessive or inaccurate projections. Here we show that the… (More)
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Highly Cited
2005
Highly Cited
2005
We show that transsynaptic apoptosis is induced in the superficial dorsal horn (laminas I-III) of the spinal cord by three… (More)
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Highly Cited
2004
Highly Cited
2004
Chronic hepatitis C virus (HCV) infection is characterized by inflammatory liver damage and is associated with a high risk of… (More)
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Highly Cited
2003
Highly Cited
2003
Omi/HtrA2 is a mitochondrial serine protease that is released into the cytosol during apoptosis to antagonize inhibitors of… (More)
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Highly Cited
2003
Highly Cited
2003
Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder caused by an abnormally expended polyglutamine… (More)
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Highly Cited
2001
Highly Cited
2001
X-linked inhibitor-of-apoptosis protein (XIAP) interacts with caspase-9 and inhibits its activity, whereas Smac (also known as… (More)
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Highly Cited
1999
Highly Cited
1999
Apoptosis and necrosis are two distinct forms of cell death that can occur in response to various agents. In the present study… (More)
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Highly Cited
1998
Highly Cited
1998
Survivin is a member of the inhibitor of apoptosis protein (IAP) family. We investigated the antiapoptotic mechanism of Survivin… (More)
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Highly Cited
1998
Highly Cited
1998
The role of caspases in B lymphocyte cell death was investigated by using two broad spectrum inhibitors of the caspase family, Z… (More)
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Highly Cited
1998
Highly Cited
1998
MEK kinase 1 (MEKK1) is a 196-kDa protein that, in response to genotoxic agents, was found to undergo phosphorylation-dependent… (More)
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