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caspase-1 activity

OBSOLETE. Catalysis of the release of interleukin 1-beta by specific cleavage of Asp116-Ala117 and Asp27-Gly28 bonds in precursor. Enzymes with this… 
National Institutes of Health

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CASP1 geneCASP1 wt AlleleCaspase-1

Broader (1)

caspase activity

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
P2Y2R activation by ATP induces oxLDL‐mediated inflammasome activation through modulation of mitochondrial damage in human endothelial cells
Highly Cited
2018
Highly Cited
2018
HSP60 critically regulates endogenous IL-1β production in activated microglia by stimulating NLRP3 inflammasome pathway
Interleukin-1β (IL-1β) is one of the most important cytokine secreted by activated microglia as it orchestrates the vicious cycle… 
2018
2018
Magnesium sulfate differentially modulates fetal membrane inflammation in a time‐dependent manner
Chorioamnionitis and infection‐associated inflammation are major causes of preterm birth. Magnesium sulfate (MgSO4) is widely… 
Highly Cited
2015
Highly Cited
2015
Reactive oxygen species activated NLRP3 inflammasomes initiate inflammation in hyperosmolarity stressed human corneal epithelial cells and environment-induced dry eye patients.
Highly Cited
2014
Highly Cited
2014
Nod-like Receptor Protein 3 (NLRP3) Inflammasome Activation and Podocyte Injury via Thioredoxin-Interacting Protein (TXNIP) during Hyperhomocysteinemia*
Background: Hyperhomocysteinemia (hHcys) contributes to glomerular injury by activating NLRP3 inflammasomes in response to… 
Highly Cited
2011
Highly Cited
2011
The inflammasome and caspase-1 activation: a new mechanism underlying increased inflammatory activity in human visceral adipose tissue.
The immune competent abdominal adipose tissue, either stored viscerally [visceral adipose tissue (VAT)] or sc [sc adipose tissue… 
Review
2009
Review
2009
Specific increase in caspase-1 activity and secretion of IL-1 family cytokines: a putative link between mevalonate kinase deficiency and inflammation.
The mevalonate kinase deficiency (MKD), including hyperimmunoglobulinemia D periodic fever syndrome (HIDS) and the more severe… 
2008
2008
Heat shock inhibits caspase‐1 activity while also preventing its inflammasome‐mediated activation by anthrax lethal toxin
Anthrax lethal toxin (LT) rapidly kills macrophages from certain mouse strains in a mechanism dependent on the breakdown of… 
Highly Cited
2007
Highly Cited
2007
Dextran sulfate sodium enhances interleukin-1 beta release via activation of p38 MAPK and ERK1/2 pathways in murine peritoneal macrophages.
2000
2000
Caspase-1 activity as a possible predictor of apoptosis induced by cisplatin in gastric cancer cells.
Recent studies have shown that caspases, which are cystein proteases, elevate endonuclease activity and induce apoptosis. Caspase… 
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