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caspase-1 activity

OBSOLETE. Catalysis of the release of interleukin 1-beta by specific cleavage of Asp116-Ala117 and Asp27-Gly28 bonds in precursor. Enzymes with this… 
National Institutes of Health

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CASP1 geneCASP1 wt AlleleCaspase-1

Broader (1)

caspase activity

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Magnesium sulfate differentially modulates fetal membrane inflammation in a time‐dependent manner
Chorioamnionitis and infection‐associated inflammation are major causes of preterm birth. Magnesium sulfate (MgSO4) is widely… 
2017
2017
The Small Tellurium Compound AS101 Ameliorates Rat Crescentic Glomerulonephritis: Association with Inhibition of Macrophage Caspase-1 Activity via Very Late Antigen-4 Inactivation
Crescentic glomerulonephritis (CGN) is the most aggressive form of GN and, if untreated, patients can progress to end-stage renal… 
Highly Cited
2015
Highly Cited
2015
Impaired NLRP3 inflammasome activity during fetal development regulates IL‐1β production in human monocytes
Interleukin‐1β (IL‐1β) production is impaired in cord blood monocytes. However, the mechanism underlying this developmental… 
2014
2014
Hyperhomocysteinemia Injury via Thioredoxin-Interacting Protein Inflammasome Activation and Podocyte Nod-like Receptor Protein 3 ( NLRP 3 ) Molecular Bases of Disease :
2011
2011
[The role of interleukin-1 and interleukin-1-receptor antagonist in development of familial mediterranean fever and other autoinflammatory diseases].
Autoinflammatory diseases constitute a group of genetic disorders whose main clinical features are recurrent episodes of… 
2008
2008
Heat shock inhibits caspase‐1 activity while also preventing its inflammasome‐mediated activation by anthrax lethal toxin
Anthrax lethal toxin (LT) rapidly kills macrophages from certain mouse strains in a mechanism dependent on the breakdown of… 
Highly Cited
2004
Highly Cited
2004
Geranylgeraniol Regulates Negatively Caspase-1 Autoprocessing: Implication in the Th1 Response against Mycobacterium tuberculosis1
Caspase-1 is a cysteine protease composed by two 20-kDa and two 10-kDa subunits that processes pro-IL-1β and pro-IL-18 to their… 
2003
2003
Interleukin-1beta responses to Mycoplasma pneumoniae infection are cell-type specific.
2001
2001
Efficient production of biologically active porcine interleukin-18 by coexpression with porcine caspase-1 using a baculovirus expression system.
We previously reported that the precursor form of porcine interleukin-18 (IL-18) expressed by the baculovirus system was able to… 
2000
2000
Caspase-1 activity as a possible predictor of apoptosis induced by cisplatin in gastric cancer cells.
Recent studies have shown that caspases, which are cystein proteases, elevate endonuclease activity and induce apoptosis. Caspase… 
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