caspase-1 activity

OBSOLETE. Catalysis of the release of interleukin 1-beta by specific cleavage of Asp116-Ala117 and Asp27-Gly28 bonds in precursor. Enzymes with this… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1964-2017
010203019642017

Papers overview

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2012
2012
Inflammasome assembly activates caspase-1 and initiates the inflammatory cell death program pyroptosis, which is protective… (More)
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Highly Cited
2011
Highly Cited
2011
OBJECTIVE Obesity is characterized by elevated levels of proinflammatory cytokines, including interleukin (IL)-1β, that… (More)
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Highly Cited
2011
Highly Cited
2011
UNLABELLED The pathogenesis of nonalcoholic steatohepatitis (NASH) and inflammasome activation involves sequential hits. The… (More)
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Highly Cited
2011
Highly Cited
2011
Acute myocardial infarction (AMI) initiates an intense inflammatory response that promotes cardiac dysfunction, cell death, and… (More)
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Highly Cited
2007
Highly Cited
2007
The proinflammatory cytokine, interleukin (IL)-1beta, is known to induce vascular dysfunction and cell death. We investigated the… (More)
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Highly Cited
2004
Highly Cited
2004
BACKGROUND Caspases are a family of aspartate-specific cysteine proteases that play an essential role in initiating and executing… (More)
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Highly Cited
2002
Highly Cited
2002
Having recently described the injurious role of caspase-1-mediated production of the proinflammatory cytokine IL-18 in ischemic… (More)
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Highly Cited
2000
Highly Cited
2000
Mutations in the copper/zinc superoxide dismutase (SOD1) gene produce an animal model of familial amyotrophic lateral sclerosis… (More)
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Highly Cited
1999
Highly Cited
1999
Recently, Salmonella spp. were shown to induce apoptosis in infected macrophages. The mechanism responsible for this process is… (More)
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Highly Cited
1998
Highly Cited
1998
Interleukin-1 beta (IL-1 beta) is a pleiotropic proinflammatory cytokine. Mechanisms leading to its secretion include not only… (More)
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