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H9c2 cardiac myoblasts undergo apoptosis in a model of ischemia consisting of serum deprivation and hypoxia: inhibition by PMA
Signaling pathways leading to the induction of ornithine decarboxylase: opposite effects of p44/42 mitogen-activated protein kinase (MAPK) and p38 MAPK inhibitors.
p44/42 mitogen-activated protein kinase is involved in the expression of ornithine decarboxylase in leukaemia L1210 cells.
- F. Flamigni, A. Facchini, C. Capanni, C. Stefanelli, B. Tantini, C. Caldarera
- Biology, ChemistryBiochemical Journal
- 15 July 1999
Results indicate that the activation of p44/42 MAPK may favour the expression of ODC, and that polyamines, in turn, may affect the phosphorylation state of MAPK.
In vitro influence of dietary protein and fructooligosaccharides on metabolism of canine fecal microbiota
Results from the present study showed that diets rich in protein may exert negative influences on the canine intestinal ecosystem, slightly increasing the presence of ammonia and reducing counts of lactobacilli and enterococci and administration of FOS may improve metabolism of canine intestinal microbiota.
Influence of dietary protein and fructooligosaccharides on fecal fermentative end-products, fecal bacterial populations and apparent total tract digestibility in dogs
Fructooligosaccharides displayed beneficial counteracting effects (such as increased bifidobacteria) when supplemented in HP diets, compared to those observed in LP diets and, in general, improved the ATTD of several minerals.
Polyamine metabolism and function in the heart.
Spermine causes caspase activation in leukaemia cells
Involvement of polyamines in apoptosis of cardiac myoblasts in a model of simulated ischemia.
Polyamines directly induce release of cytochrome c from heart mitochondria.
The data indicate a novel mechanism of cytochrome c release from the mitochondrion, and suggest that prolonged and sustained elevation of polyamines, characteristic of some pathologies such as heart hypertrophy, could be involved in the development of apoptosis.
Signal transduction pathways linking polyamines to apoptosis
A picture is drawn about the role of polyamines in signalling pathways related to apoptotic cell death and the proposed molecular targets of these polycations at the level of the apoptotic cascade.