caspase-3 activity

OBSOLETE. Catalysis of the cleavage at the terminal bond of the motif: Asp-Xaa-Xaa-Asp-Xaa. Enzymes with this function are members of the peptidase… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1997-2017
010020030019972017

Papers overview

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Highly Cited
2011
Highly Cited
2011
Synaptic loss is the best pathological correlate of the cognitive decline in Alzheimer's disease; however, the molecular… (More)
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Highly Cited
2010
Highly Cited
2010
MicroRNAs (miRNAs) are small noncoding RNA molecules that regulate protein expression by cleaving or repressing the translation… (More)
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Highly Cited
2006
Highly Cited
2006
alpha-1 Antitrypsin (A1AT) is an abundant circulating serpin with a postulated function in the lung of potently inhibiting… (More)
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Highly Cited
2005
Highly Cited
2005
Diabetes leads to vascular leakage, glial dysfunction, and neuronal apoptosis within the retina. The goal of the studies reported… (More)
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Highly Cited
2001
Highly Cited
2001
Bisphosphonates inhibit osteoclast-mediated bone resorption by mechanisms that have only recently become clear. Whereas nitrogen… (More)
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Highly Cited
2000
Highly Cited
2000
BACKGROUND Diabetes mellitus causes multiple cardiovascular complications. High glucose can induce reactive oxygen species and… (More)
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Highly Cited
1999
Highly Cited
1999
The aim of this study was to investigate the mechanism of flavonoid-induced apoptosis in HL-60 leukaemic cells. Thus, the effect… (More)
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Highly Cited
1998
Highly Cited
1998
Delayed neuronal death after transient cerebral ischemia may be mediated, in part, by the induction of apoptosis-regulatory gene… (More)
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Highly Cited
1998
Highly Cited
1998
Progression of the cell cycle and control of apoptosis (programmed cell death) are thought to be intimately linked processes… (More)
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Highly Cited
1997
Highly Cited
1997
The caspase (ICE/CED-3) family of proteases has been implicated to play a crucial role in apoptosis. However, the mechanisms by… (More)
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