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Cancer chemoprevention and chemotherapy: dietary polyphenols and signalling pathways.
  • S. Ramos
  • Biology, Medicine
  • Molecular nutrition & food research
  • 1 May 2008
Prevention of cancer through dietary intervention recently has received an increasing interest, and dietary polyphenols have become not only important potential chemopreventive, but also therapeutic,Expand
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Response of the antioxidant defense system to tert‐butyl hydroperoxide and hydrogen peroxide in a human hepatoma cell line (HepG2)
The aim of this work was to investigate the response of the antioxidant defense system to two oxidative stressors, hydrogen peroxide and tert‐butyl hydroperoxide, in HepG2 cells in culture. TheExpand
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Determination of malondialdehyde (MDA) by high-performance liquid chromatography in serum and liver as a biomarker for oxidative stress. Application to a rat model for hypercholesterolemia and
A high-performance liquid chromatography (HPLC) method to determine malondialdehyde (MDA) as the 2,4-dinitrophenylhydrazine (DNPH) derivative was applied to biological samples (serum and liverExpand
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Influence of quercetin and rutin on growth and antioxidant defense system of a human hepatoma cell line (HepG2)
SummaryBackgroundDietary polyphenols like quercetin and rutin are considered beneficial because of their potential protective role in the pathogenesis of multiple diseases associated to oxidativeExpand
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A diet rich in dietary fiber from cocoa improves lipid profile and reduces malondialdehyde in hypercholesterolemic rats.
OBJECTIVE The potential hypolipidemic effect of a new cocoa product rich in dietary fiber (DF) naturally containing antioxidant polyphenols (cocoa fiber [CF]) was studied in a rat model ofExpand
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Effects of dietary flavonoids on apoptotic pathways related to cancer chemoprevention.
  • S. Ramos
  • Biology, Medicine
  • The Journal of nutritional biochemistry
  • 1 July 2007
Epidemiological studies have described the beneficial effects of dietary polyphenols (flavonoids) on the reduction of the risk of chronic diseases, including cancer. Moreover, it has been shown thatExpand
  • 531
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Quercetin induces apoptosis via caspase activation, regulation of Bcl-2, and inhibition of PI-3-kinase/Akt and ERK pathways in a human hepatoma cell line (HepG2).
Dietary polyphenols have been associated with the reduced risk of chronic diseases such as cancer, but the precise underlying mechanism of protection remains unclear. The aim of this study was toExpand
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Quercetin protects human hepatoma HepG2 against oxidative stress induced by tert-butyl hydroperoxide.
Flavonols such as quercetin, have been reported to exhibit a wide range of biological activities related to their antioxidant capacity. The objective of the present study was to investigate theExpand
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Cocoa polyphenols prevent inflammation in the colon of azoxymethane-treated rats and in TNF-α-stimulated Caco-2 cells
Numerous lines of evidence support a relationship between intestinal inflammation and cancer. Therefore, much attention has recently been focused on the identification of natural compounds withExpand
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Quercetin modulates Nrf2 and glutathione-related defenses in HepG2 cells: Involvement of p38.
Dietary flavonoid quercetin has been suggested as a cancer chemopreventive agent, but the mechanisms of action remain unclear. This study investigated the influence of quercetin on p38-MAPK and theExpand
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