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calyculin

 
National Institutes of Health

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2 relations

Broader (1)

Antineoplastic Agents
animal extract

Papers overview

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Highly Cited
2014
Highly Cited
2014
Calyculin biogenesis from a pyrophosphate protoxin produced by a sponge symbiont.
The Japanese marine sponge Discodermia calyx contains a major cytotoxic compound, calyculin A, which exhibits selective… Expand
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Highly Cited
2002
Highly Cited
2002
Serine phosphorylation of insulin receptor substrate 1 by inhibitor kappa B kinase complex.
Insulin resistance contributes importantly to the pathophysiology of type 2 diabetes mellitus. One mechanism mediating insulin… Expand
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Highly Cited
2002
Highly Cited
2002
A Mass Spectrometry-based Proteomic Approach for Identification of Serine/Threonine-phosphorylated Proteins by Enrichment with Phospho-specific Antibodies
Although proteins phosphorylated on tyrosine residues can be enriched by immunoprecipitation with anti-phosphotyrosine antibodies… Expand
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Highly Cited
2002
Highly Cited
2002
Multilevel Dysregulation of STAT3 Activation in Anaplastic Lymphoma Kinase-Positive T/Null-Cell Lymphoma1
Accumulating evidence indicates that expression of anaplastic lymphoma kinase (ALK), typically due to t(2;5) translocation… Expand
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Highly Cited
2001
Highly Cited
2001
Coordinated Control of Endothelial Nitric-oxide Synthase Phosphorylation by Protein Kinase C and the cAMP-dependent Protein Kinase*
Endothelial nitric-oxide synthase (eNOS) is an important regulatory enzyme in the cardiovascular system catalyzing the production… Expand
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Highly Cited
2001
Highly Cited
2001
Phosphorylation of Thr(495) regulates Ca(2+)/calmodulin-dependent endothelial nitric oxide synthase activity.
The activity of the endothelial nitric oxide synthase (eNOS) can be regulated independently of an increase in Ca(2+) by the… Expand
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Highly Cited
1997
Highly Cited
1997
Low-Frequency Stimulation of Afferent Aδ-Fibers Induces Long-Term Depression at Primary Afferent Synapses with Substantia Gelatinosa Neurons in the Rat
Impulses in primary afferent nerve fibers may produce short- or long-lasting modifications in spinal nociception. Here we have… Expand
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Highly Cited
1997
Highly Cited
1997
Protein Kinase C-mediated Phosphorylation and Functional Regulation of Dopamine Transporters in Striatal Synaptosomes*
Dopamine transporters (DATs) are members of a family of Na+- and Cl−-dependent neurotransmitter transporters responsible for the… Expand
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Highly Cited
1996
Highly Cited
1996
Tumor cell resistance to apoptosis due to a defect in the activation of sphingomyelinase and the 24 kDa apoptotic protease (AP24)
Signal transduction pathways involved in apoptotic cell death are poorly understood, although recent studies have implicated… Expand
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Highly Cited
1990
Highly Cited
1990
Hepatocyte deformation induced by cyanobacterial toxins reflects inhibition of protein phosphatases.
The cyclic peptide hepatotoxins microcystin-LR, 7-desmethyl-microcystin-RR and nodularin are potent inhibitors of the protein… Expand
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