calyculin

 
National Institutes of Health

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Antineoplastic Agents
animal extract

Papers overview

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2014
2014
Calyculin biogenesis from a pyrophosphate protoxin produced by a sponge symbiont.
The Japanese marine sponge Discodermia calyx contains a major cytotoxic compound, calyculin A, which exhibits selective… (More)
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Highly Cited
2007
Highly Cited
2007
Actin–myosin network reorganization breaks symmetry at the cell rear to spontaneously initiate polarized cell motility
We have analyzed the spontaneous symmetry breaking and initiation of actin-based motility in keratocytes (fish epithelial cells… (More)
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Highly Cited
2004
Highly Cited
2004
Adenosine receptor, protein kinase G, and p38 mitogen-activated protein kinase-dependent up-regulation of serotonin transporters involves both transporter trafficking and activation.
Serotonin (5-hydroxytryptamine; 5-HT) transporters (SERTs) are critical determinants of synaptic 5-HT inactivation and the… (More)
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Highly Cited
2002
Highly Cited
2002
Serine phosphorylation of insulin receptor substrate 1 by inhibitor kappa B kinase complex.
Insulin resistance contributes importantly to the pathophysiology of type 2 diabetes mellitus. One mechanism mediating insulin… (More)
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Highly Cited
2001
Highly Cited
2001
Phosphorylation of Thr(495) regulates Ca(2+)/calmodulin-dependent endothelial nitric oxide synthase activity.
The activity of the endothelial nitric oxide synthase (eNOS) can be regulated independently of an increase in Ca(2+) by the… (More)
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Highly Cited
2001
Highly Cited
2001
Coordinated control of endothelial nitric-oxide synthase phosphorylation by protein kinase C and the cAMP-dependent protein kinase.
Endothelial nitric-oxide synthase (eNOS) is an important regulatory enzyme in the cardiovascular system catalyzing the production… (More)
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Highly Cited
2000
Highly Cited
2000
Cocaine and antidepressant-sensitive biogenic amine transporters exist in regulated complexes with protein phosphatase 2A.
Presynaptic transporter proteins regulate the clearance of extracellular biogenic amines after release and are important targets… (More)
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Highly Cited
1997
Highly Cited
1997
Low-frequency stimulation of afferent Adelta-fibers induces long-term depression at primary afferent synapses with substantia gelatinosa neurons in the rat.
Impulses in primary afferent nerve fibers may produce short- or long-lasting modifications in spinal nociception. Here we have… (More)
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Highly Cited
1997
Highly Cited
1997
Activation of the avian erythrocyte Na-K-Cl cotransport protein by cell shrinkage, cAMP, fluoride, and calyculin-A involves phosphorylation at common sites.
Na-K-Cl cotransport activity in duck erythrocytes increases approximately 10-fold in response to osmotic cell shrinkage… (More)
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Highly Cited
1992
Highly Cited
1992
Cytoskeletal integrity in interphase cells requires protein phosphatase activity.
Phosphorylation by protein kinases has been established as a key factor in the regulation of cytoskeletal structure. However… (More)
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