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calyculin

National Institutes of Health

Related topics

Related topics

2 relations

Broader (1)

Antineoplastic Agents
animal extract

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2014
Highly Cited
2014
Calyculin biogenesis from a pyrophosphate protoxin produced by a sponge symbiont.
The Japanese marine sponge Discodermia calyx contains a major cytotoxic compound, calyculin A, which exhibits selective… 
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Highly Cited
2002
Highly Cited
2002
Serine phosphorylation of insulin receptor substrate 1 by inhibitor kappa B kinase complex.
Insulin resistance contributes importantly to the pathophysiology of type 2 diabetes mellitus. One mechanism mediating insulin… 
Highly Cited
2002
Highly Cited
2002
A Mass Spectrometry-based Proteomic Approach for Identification of Serine/Threonine-phosphorylated Proteins by Enrichment with Phospho-specific Antibodies
Although proteins phosphorylated on tyrosine residues can be enriched by immunoprecipitation with anti-phosphotyrosine antibodies… 
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Highly Cited
2001
Highly Cited
2001
Coordinated Control of Endothelial Nitric-oxide Synthase Phosphorylation by Protein Kinase C and the cAMP-dependent Protein Kinase*
Endothelial nitric-oxide synthase (eNOS) is an important regulatory enzyme in the cardiovascular system catalyzing the production… 
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Highly Cited
2001
Highly Cited
2001
Phosphorylation of Thr(495) regulates Ca(2+)/calmodulin-dependent endothelial nitric oxide synthase activity.
The activity of the endothelial nitric oxide synthase (eNOS) can be regulated independently of an increase in Ca(2+) by the… 
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Highly Cited
2000
Highly Cited
2000
Ceramide Inhibits Protein Kinase B/Akt by Promoting Dephosphorylation of Serine 473*
The second messenger ceramide (N-alkylsphingosine) has been implicated in a host of cellular processes including growth arrest… 
Highly Cited
1997
Highly Cited
1997
Low-Frequency Stimulation of Afferent Aδ-Fibers Induces Long-Term Depression at Primary Afferent Synapses with Substantia Gelatinosa Neurons in the Rat
Impulses in primary afferent nerve fibers may produce short- or long-lasting modifications in spinal nociception. Here we have… 
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Highly Cited
1997
Highly Cited
1997
Protein Kinase C-mediated Phosphorylation and Functional Regulation of Dopamine Transporters in Striatal Synaptosomes*
Dopamine transporters (DATs) are members of a family of Na+- and Cl−-dependent neurotransmitter transporters responsible for the… 
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Highly Cited
1996
Highly Cited
1996
Tumor cell resistance to apoptosis due to a defect in the activation of sphingomyelinase and the 24 kDa apoptotic protease (AP24)
Signal transduction pathways involved in apoptotic cell death are poorly understood, although recent studies have implicated… 
Highly Cited
1990
Highly Cited
1990
Hepatocyte deformation induced by cyanobacterial toxins reflects inhibition of protein phosphatases.
The cyclic peptide hepatotoxins microcystin-LR, 7-desmethyl-microcystin-RR and nodularin are potent inhibitors of the protein… 
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