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Calyculin A and okadaic acid: inhibitors of protein phosphatase activity.
TLDR
The pattern of inhibition for the phosphatase in myosin B is similar to that of the type-1 enzyme, and the effects of both compounds on various phosphatases are screened. Expand
Raf-1 activates MAP kinase-kinase
TLDR
Results indicate that c-Raf-1 is an immediate upstream activator of MAPK-K in vivo, the first physiological substrate of the c-raf-l protooncogene product to be identified. Expand
Regulation of protein serine-threonine phosphatase type-2A by tyrosine phosphorylation.
TLDR
Transient deactivation of phosphatase 2A might enhance transmission of cellular signals through kinase cascades within cells through kinases within cells. Expand
Agonists Trigger G Protein-mediated Activation of the CPI-17 Inhibitor Phosphoprotein of Myosin Light Chain Phosphatase to Enhance Vascular Smooth Muscle Contractility*
TLDR
The results show that agonists such as histamine signal through phosphorylation of CPI-17 to produce Ca2+ sensitization of smooth muscle contraction. Expand
Histamine-induced Vasoconstriction Involves Phosphorylation of a Specific Inhibitor Protein for Myosin Phosphatase by Protein Kinase C α and δ Isoforms*
TLDR
The results imply that histamine stimulation elicits contraction of vascular smooth muscle through activation of PKCα and especially PKCδ to phosphorylate CPI-17. Expand
Midzone activation of aurora B in anaphase produces an intracellular phosphorylation gradient
TLDR
It is proposed that feedback between aurora B kinase activation and midzone microtubules generates a gradient of post-translational marks that provides spatial information for events in anaphase and cytokinesis. Expand
Expression of CPI‐17 and myosin phosphatase correlates with Ca2+ sensitivity of protein kinase C‐induced contraction in rabbit smooth muscle
TLDR
The expression ratio of CPI‐17 to MLCP correlates with the Ca2+ sensitivities of contraction induced by a PKC activator, which implicates CPI‐ 17 inhibition of M LCP as an important component in modulating vascular muscle tone. Expand
The Specificity of Extracellular Signal-regulated Kinase 2 Dephosphorylation by Protein Phosphatases*
TLDR
A kinetic analysis of ERK2 dephosphorylation by protein phosphatases using a continuous spectrophotometric enzyme-coupled assay provides biochemical evidence that proteinosphatases display exquisite specificity in their substrate recognition and implicate HePTP, MKP3, and PP2A as ERK1 phosphatase as well as Ser/Thr protein phosph atases. Expand
Polyoma small and middle T antigens and SV40 small t antigen form stable complexes with protein phosphatase 2A
TLDR
Immunoblotting experiments, comigration on 2D gels, and 2D analysis of limit chymotryptic digests demonstrated that the 63 kd protein, present in the middle T complex in approximately equimolar ratio to the 36 kdprotein, is a known regulatory subunit of the PP2A holoenzyme. Expand
Histamine-induced vasoconstriction involves phosphorylation of a specific inhibitor protein for myosin phosphatase by protein kinase C alpha and delta isoforms.
TLDR
The results imply that histamine stimulation elicits contraction of vascular smooth muscle through activation of PKC alpha and especially PKC delta to phosphorylate CPI-17. Expand
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