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Cytotoxic metabolites from the fungal endophyte Alternaria sp. and their subsequent detection in its host plant Polygonum senegalense.
From the Egyptian medicinal plant Polygonum senegalense the fungal endophyte Alternaria sp. was isolated. Extracts of the fungus grown either in liquid culture or on solid rice media exhibitedExpand
Secondary metabolites of fungi from marine habitats.
TLDR
An overview of new natural products from marine-derived fungi and their biological activities, focusing on the period from 2006 until mid-2010, with a considerable number of which display promising biological and pharmacological properties. Expand
Activated Chemical Defense in Aplysina Sponges Revisited
TLDR
It is concluded that tissue damage induces a bioconversion of isoxazoline alkaloids into aeroplysinin-1 and dienone in Aplysina sponges, and this reaction is likely catalyzed by enzymes, and it may be ecologically relevant as theBioconversion products possibly protect the wounded sponge tissue from invasion of bacterial pathogens. Expand
New metabolites from sponge-derived fungi Curvularia lunata and Cladosporium herbarum.
TLDR
The fungus Curvularia lunata, isolated from the marine sponge Niphates olemda, yielded the new 1,3,8-trihydroxy-6-methoxyanthraquinone, which was named lunatin and both anthraquinones were found to be active against Bacillus subtilis, Staphylococcus aureus, and Escherichia coli. Expand
Enniatins A1, B and B1 from an endophytic strain of Fusarium tricinctum induce apoptotic cell death in H4IIE hepatoma cells accompanied by inhibition of ERK phosphorylation.
TLDR
Enniatins A1 and B1 and, to a lesser extent, enniatin B may possess anticarcinogenic properties by induction of apoptosis and disruption of ERK signalling pathway. Expand
Xanalteric acids I and II and related phenolic compounds from an endophytic Alternaria sp. isolated from the mangrove plant Sonneratia alba.
Two new 10-oxo-10H-phenaleno[1,2,3-de]chromene-2-carboxylic acids, xanalteric acids I (1) and II (2), and 11 known secondary metabolites were obtained from extracts of the endophytic fungusExpand
Wound Activation of Protoxins in Marine Sponge Aplysina aerophoba
TLDR
Findings suggest that the enzyme activities studied are linked to the accumulation of suitable substrates and hence represent a specific biochemical property of sponges from the genus Aplysina. Expand
Sponge-associated fungi and their bioactive compounds : The Suberites case
TLDR
Viridicatin, viridicatol, cyclopenin and cyclopenol suppressed larval growth of the polyphagous pest insect Spodoptera littoralis when incorporated into an artificial diet at an arbitrarily chosen concentration of 237 ppm. Expand
Bioactive metabolites from the endophytic fungus Stemphylium globuliferum isolated from Mentha pulegium.
TLDR
The endophytic fungus Stemphylium globuliferum was isolated from stem tissues of the Moroccan medicinal plant Mentha pulegium, and extracts of the fungus exhibited considerable cytotoxicity when tested in vitro against L5178Y cells. Expand
Chaxapeptin, a Lasso Peptide from Extremotolerant Streptomyces leeuwenhoekii Strain C58 from the Hyperarid Atacama Desert.
TLDR
Genome mining-targeted discovery of new natural products from microbes obtained from extreme environments has led to the identification of a gene cluster directing the biosynthesis of a new lasso peptide, designated as chaxapeptin 1, in the genome of Streptomyces leeuwenhoekii strain C58 isolated from the Atacama Desert. Expand
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