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bufuralol

Known as: 1-(7-ethylbenzofuran-2-yl)-2-tert-butylamino-1-hydroxyethane, Bufuralolum 
National Institutes of Health

Related topics

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2 relations

Broader (2)

Adrenergic beta-AntagonistsEthanolamines

Papers overview

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Highly Cited
2011
Highly Cited
2011
Rapid and sensitive drug metabolism studies by SU-8 microchip capillary electrophoresis-electrospray ionization mass spectrometry.
Highly Cited
2003
Highly Cited
2003
Residues Glutamate 216 and Aspartate 301 Are Key Determinants of Substrate Specificity and Product Regioselectivity in Cytochrome P450 2D6*
Cytochrome P450 2D6 (CYP2D6) metabolizes a wide range of therapeutic drugs. CYP2D6 substrates typically contain a basic nitrogen… 
2002
2002
CYP2D6.10 present in human liver microsomes shows low catalytic activity and thermal stability.
Highly Cited
2001
Highly Cited
2001
Characterization of (+/-)-bufuralol hydroxylation activities in liver microsomes of Japanese and Caucasian subjects genotyped for CYP2D6.
Twenty-four genetic polymorphisms in the CYP2D6 gene were analysed in liver DNA samples of 39 Japanese and 44 Caucasians and… 
Highly Cited
1999
Highly Cited
1999
The role of CYP2C19 in the metabolism of (+/-) bufuralol, the prototypic substrate of CYP2D6.
Upon characterization of baculovirus-expressed cytochrome P-450 (CYP) 2C19, it was observed that this enzyme metabolized… 
Highly Cited
1986
Highly Cited
1986
The molecular mechanisms of two common polymorphisms of drug oxidation--evidence for functional changes in cytochrome P-450 isozymes catalysing bufuralol and mephenytoin oxidation.
Using the stereospecific metabolism of (+)- and (-)-bufuralol and (+)- and (-)-metoprolol as model reactions, we have… 
Highly Cited
1985
Highly Cited
1985
Inhibition of desmethylimipramine 2-hydroxylation by drugs in human liver microsomes.
Highly Cited
1985
Highly Cited
1985
Substrate specificity of human liver cytochrome P-450 debrisoquine 4-hydroxylase probed using immunochemical inhibition and chemical modeling.
A significant population of humans (5 to 10%) are phenotypic poor metabolizers of debrisoquine. We have isolated the cytochrome P… 
1984
1984
Bufuralol metabolism in human liver: a sensitive probe for the debrisoquine‐type polymorphism of drug oxidation
Abstract. The genetically controlled polymorphism causing decreased metabolism of debrisoquine is closely related to that of the… 
1980
1980
Influence of renal failure on the hepatic clearance of bufuralol in man
The beta-blocking agent bufuralol is subject to first-pass metabolism and is eliminated from the body almost entirely by… 
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