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The kidney in maturity onset diabetes mellitus: a clinical study of 510 patients.
The results revealed an evolution which is quite different from that seen in juvenile onset, insulin-dependent diabetes mellitus, andphasis in this study was placed on hypertension, frequently observed in patients, and on quantitative as well as qualitative protein excretion, which provide a useful marker of glomerular or tubule dysfunction when analyzed according to the molecular weight of the various fractions excreted.
Diet and opiate addiction: a quantitative assessment of the diet of non-institutionalized opiate addicts.
- A. Morabia, J. Fabre, E. Chee, S. Žeger, E. Orsat, A. Robert
- Medicine, PsychologyBritish journal of addiction
- 1 February 1989
Results show that, after adjustment for age and alcohol intake, male addicts have the same caloric intake as non-addicts, however, addicts tend to replace foods that are rich in fat and proteins with foods rich in sucrose and relatively poor in vitamins and minerals.
Renal Failure, Drug Pharmacokinetics and Drug Action
A critical analysis of the proposed methods of adapting drug dosage in renal insufficiency is presented and it is shown that all patients with renal disease must be monitored closely, particularly for signs of unexpected drug toxicity.
Cefoperazone: pharmacokinetics in humans with normal and impaired renal function and pharmacokinetics in rats.
Pharmacokinetics of glipizide in man: Influence of renal insufficiency
The administration of14C-glipizide to two patients with renal insufficiency showed that the metabolism of the drug is independent of kidney function, and that the rate of disappearance of the unchanged glipizides was approximately the same as in normals, but that the “halflife” of the metabolites was increased to 20 h and more.
Des 4-trans-hydroxy-glibenclamide show hypoglycemic activity?
Comparison of the doses capable of producing a 30% decrease of the glycemia shows that 4-transhydroxy-glibenclamide is about 6.5 times less potent than glibenClamide in the authors' experimental conditions.
The influence of patient and physician gender on prescription of psychotropic drugs.
Female patients were significantly more likely to be prescribed psychotropic drugs of all types from a female than from a male physician, and information on patient diagnosis or on severity of symptoms would be needed to determine whether the present results reflect gender differences in medical care needs.
Influence of renal failure on the hepatic clearance of bufuralol in man
- L. Balant, R. Francis, T. Tozer, A. Marmy, J. Tschopp, J. Fabre
- Medicine, BiologyJournal of Pharmacokinetics and Biopharmaceutics
- 1 October 1980
From this analysis it appears that the presystemic biotransformation of bufuralol is decreased in renal failure and that changes in systemic clearance are compensated in patients by modifications of the volume of distribution, resulting in little net change in the halflife of elimination.
Behaviour of doxycycline in the tissues.
Doxycycline is capable of penetrating extremely rapidly and intensely into tissues, while still retaining a great degree of freedom of movement between plasma and tissues.
Behaviour of glibenclamide on repeated administration to diabetic patients
- L. Balant, G. Zahnd, F. Weber, J. Fabre
- Medicine, BiologyEuropean Journal of Clinical Pharmacology
Measured glibenclamide blood levels were in close agreement with an analogue computer simulation of data obtained from healthy volunteers: there was no accumulation of drug in the blood, but there was strong evidence for the existence of a slowly equilibrating “deep” compartment.