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Pharmacokinetics of glipizide in man: Influence of renal insufficiency
TLDR
The administration of14C-glipizide to two patients with renal insufficiency showed that the metabolism of the drug is independent of kidney function, and that the rate of disappearance of the unchanged glipizides was approximately the same as in normals, but that the “halflife” of the metabolites was increased to 20 h and more.
Simultaneous tubular excretion and reabsorption of pindolol in man
TLDR
It is shown that the renal elimination of pindolol in man comprises of two separate processes — tubular secretion and reabsorption, which was partially saturable under the experimental conditions.
[Retention of metabolites of a beta-blocking drug, oxprenolol, in renal insufficiency].
TLDR
From measurement of the exercise-stimulated heart rate it can be concluded that active metabolites of oxprenolol are absent, and the present study failed to show hydrolysis of the conjugates with liberation of the active parent compound.
[Pharmacokinetics of two beta blocking drugs: detection of a pharmacogenetic abnormality].
TLDR
In one subject, the apparent half-life of elimination was increased from 2.5 h (normal subjects) to 5 h for both drugs, a peculiarity which can be explanined by a decreased rate of metabolism for these two drugs.
The genetic control of bufuralol metabolism in man.
TLDR
Determination of the plasma metabolic ratio in the family of this subject and in a larger population confirmed that aliphatic hydroxylation of bufuralol is under polymorphic control.
[Role of metabolites in the relationship between pharmacokinetics and the effect of beta blockers. Studies on tolamolol and bufuralol].
TLDR
The results of the present study emphasize the importance of measuring metabolites when dose-action relationships are investigated and demonstrate a good correlation between parent drug blood levels and the pharmacodynamic effect of the two beta-blocking agents.
THE DURATION OF ACTION OF PINDOLOL and ITS RELATION TO PLASMA LEVELS
TLDR
The purpose of the present study was to investigate the relationship between blood levels of pindolol and its pharmacological effect, and to assess whether the existence of such a relationship has any clinical significance.
[Clearance concept applied to pharmacokinetics: 2. Experience with tolamolol (beta-blocking agent) in renal insufficiency (author's transl)].
TLDR
It appears that the presystemic biotransformation of tolamolol is decreased in renal failure, compared with normal volunteers and in patients with severe renal insufficiency.
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