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Pharmacology of midazolam.
8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine (midazolam, Ro 21-3981, Dormicum) is an imidazobenzodiazepine whose salts are soluble and stable in aqueous solution. It hasExpand
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Cilazapril Prevents Hypertension in Spontaneously Hypertensive Rats
Summary: Chronic daily administration of cilazapril (1 x 10 mg/kg/day p.o., from age 4 to 14 weeks) to young spontaneously hypertensive rats (SHR) prevented the development of hypertension. TheExpand
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An angiotensin with prolonged action and blood pressure--lowering properties.
[Sar1,Phe(Br5)8] angiotensin II (Br5Ang II) is a specific, quasi-irreversible antagonist of angiotensin II (Ang II) in vitro. In vivo, this compound is a very potent, Ang II-specific antagonist withExpand
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Analysis of cardiac chronotropic responses to some autonomic blocking agents in conscious trained dogs.
The changes of heart rate in response to i.v. administration of methylatropine (0.5 mg/kg) and/or propranolol (2 mg/Kg) or practolol (2.5 mg/Kg) were studied in conscious trained dogs. CholinergicExpand
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Cardiovascular effects of a novel vasoactive antihypertensive agent, Ro 12-4713.
Ro 12-4713, an oxadiazolopyrimidine derivative, lowered blood pressure of conscious spontaneously hypertensive rats and renal hypertensive dogs in a dose-dependent manner from 10 to 100 mg/kg p.o.Expand
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Measurement of blood pressure in unanaesthetized rats and mice.
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Genetically hypertensive rats: Relationship between the development of hypertension and the changes in norepinephrine turnover of peripheral and central adrenergic neurons
SummaryIn genetically hypertensive rats, the norepinephrine turnover of peripheral and central adrenergic neurons was determined either by the decline in endogenous norepinephrine after inhibition ofExpand
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Cardiovascular Effects of the New Angiotensin-Converting-Enzyme Inhibitor, Cilazapril, in Anesthetized and Conscious Dogs
Summary: Cilazapril is a new angiotensin-converting-enzyme inhibitor. In conscious renal-hypertensive dogs, cilazapril (2 × 10 mg/kg/day p.o.) caused a long-lasting (>24 h) decrease in systolicExpand
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