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botrocetin

Known as: Bothrops venom factor, venom coagglutinin 
National Institutes of Health

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1 relation

Broader (1)

Crotalid Venoms

Papers overview

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2006
2006
von Willebrand factor mediates platelet spreading through glycoprotein Ib and alpha(IIb)beta3 in the presence of botrocetin and ristocetin, respectively.
BACKGROUND von Willebrand factor (VWF) plays a critical role in the process of hemostasis by mediating flow-dependent adhesion… 
Highly Cited
2000
Highly Cited
2000
Localization of von Willebrand Factor-binding Sites for Platelet Glycoprotein Ib and Botrocetin by Charged-to-Alanine Scanning Mutagenesis*
At sites of vascular injury, von Willebrand factor (VWF) mediates platelet adhesion through binding to platelet glycoprotein Ib… 
1998
1998
A heat shock‐related protein, p20, plays an inhibitory role in platelet activation
Highly Cited
1996
Highly Cited
1996
Mocarhagin, a novel cobra venom metalloproteinase, cleaves the platelet von Willebrand factor receptor glycoprotein Ibalpha. Identification of the sulfated tyrosine/anionic sequence Tyr-276-Glu-282…
Platelet adhesion to the subendothelium is the initiating event in hemostasis and thrombosis and involves the binding of von… 
Highly Cited
1993
Highly Cited
1993
Isolation and characterization of an anticoagulant protein homologous to botrocetin from the venom of Bothrops jararaca.
We previously isolated a unique anticoagulant protein named IX/X-bp (factor IX/factor X-binding protein) from the venom of the… 
Highly Cited
1990
Highly Cited
1990
Ristocetin and Botrocetin Involve Two Distinct Domains of von Willebrand Factor for Binding to Platelet Membrane Glycoprotein lb
Summary We have evidence that ristocetin and botrocetin mediate binding of von Willebrand Factor (vWF) to platelet glycoprotein… 
Highly Cited
1989
Highly Cited
1989
Role of botrocetin in platelet agglutination: formation of an activated complex of botrocetin and von Willebrand factor
Botrocetin (venom coagglutinin) induces binding of von Willebrand factor (vWF) to platelet glycoprotein Ib (GPIb), resulting in… 
Highly Cited
1989
Highly Cited
1989
Cross-linking of a monomeric 39/34-kDa dispase fragment of von Willebrand factor (Leu-480/Val-481-Gly-718) to the N-terminal region of the alpha-chain of membrane glycoprotein Ib on intact platelets…
A 39/34-kilodalton (kDa) monomeric dispase fragment of von Willebrand factor (vWF) has been purified by heparin affinity… 
1987
1987
The von willebrand factor domain-mediating botrocetin-induced binding to glycoprotein IB lies between Val449 and Lys728.
Botrocetin, a component of Bothrops jararaca venom, induces von Willebrand factor (vWF)-dependent platelet agglutination and has… 
1984
1984
The agglutination of human platelets by botrocetin: evidence that botrocetin and ristocetin act at different sites on the factor VIII molecule and platelet membrane
Summary. Botrocetin caused a factor VIII (FVIII) dependent platelet agglutination which was associated with a reduction in the… 
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