• Publications
  • Influence
PECAM-1 (CD31) cloning and relation to adhesion molecules of the immunoglobulin gene superfamily.
An antibody to a platelet integral membrane glycoprotein was found to cross-react with the previously identified CD31 myelomonocytic differentiation antigen and with hec7, an endothelial cell proteinExpand
Platelet Glycoprotein Ibα Is a Counterreceptor for the Leukocyte Integrin Mac-1 (Cd11b/Cd18)
The platelet counterreceptor is identified as glycoprotein (GP) Ibα, a component of the GP Ib-IX-V complex, the platelet von Willebrand factor (vWf) receptor, which provides a molecular target for disrupting leukocyte–platelet complexes that promote vascular inflammation in thrombosis, atherosclerosis, and angioplasty-related restenosis. Expand
The Glycoprotein Ib-IX-V Complex Is a Platelet Counterreceptor for P-Selectin
The GP Ib-IX-V complex mediates platelet attachment to both subendothelium and activated endothelium, and the interaction with GP Ibα required neither calcium nor carbohydrate core-2 branching or α(1,3)-fucosylation. Expand
Platelet physiology and thrombosis.
The structure-function of primary platelet adhesion receptors, GPIb-IX-V and GPVI, and how they act together to regulate platelet thrombus formation in pathophysiology are focused on. Expand
PETA-3/CD151, a member of the transmembrane 4 superfamily, is localised to the plasma membrane and endocytic system of endothelial cells, associates with multiple integrins and modulates cell
A primary role for PETA-3 in regulating integrin trafficking and/or function is suggested after co-immunoprecipitation experiments demonstrated associations with several integrin chains including beta1, beta3, beta4, (beta)2, (alpha)3, ( alpha)5, (Alpha)6 and provide the first report of Transmembrane 4 Superfamily association with the ( Alpha)6beta4 integrin. Expand
Molecular cloning of cDNA encoding a novel platelet-endothelial cell tetra-span antigen, PETA-3.
Northern blot analysis of RNA from a range of human tissues indicated that the transcript was present in most tissues, the notable exception being brain, and isolation of a cDNA clone encoding PETA-3 from a library derived from the megakaryoblastic leukemia cell line MO7e is reported. Expand
Controlled shedding of platelet glycoprotein (GP)VI and GPIb–IX–V by ADAM family metalloproteinases
These findings suggest surface levels of GPVI, GPIbα and GPV may be controlled by distinct mechanisms involving ADAM10 and/or ADAM17. Expand
P-selectin Glycoprotein Ligand-1 Is the Major Counter-receptor for P-selectin on Stimulated T Cells and Is Widely Distributed in Non-functional Form on Many Lymphocytic Cells *
The activities of two glycosyltransferases reportedly involved in the production of functional PSGL-1 in myeloid cells are substantially higher in the stimulated T-lymphocytic lines than in resting T lymphocytes, consistent with the hypothesis that activation-dependent post-translational events contribute to the expression of functional P-selectin on lymphocytes. Expand
Mechanism of Activation of the GM‐CSF, IL‐3, and IL‐5 Family of Receptors
A number of very recent and interesting findings have identified unique features in this receptor system in terms of how GM‐CSF/il‐3/IL‐5 bind, oligomerize, and activate their cognate receptors and how the presence of novel phosphotyrosine‐independent signaling motifs within a specific cytoplasmic domain of βC may be important for mediating survival and differentiation by these cytokines. Expand
The SH2-containing inositol polyphosphate 5-phosphatase, SHIP-2, binds filamin and regulates submembraneous actin
It is demonstrated that filamin-dependent SHIP-2 localization critically regulates phosphatidylinositol 3 kinase signaling to the actin cytoskeleton. Expand