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Snake venom proteases affecting hemostasis and thrombosis.
Mutations and common polymorphisms in ADAMTS13 gene responsible for von Willebrand factor-cleaving protease activity
A single-nucleotide polymorphism associated with alterations in VWF-CP activity is reported and it will be important to assess this single- nucleotide SNP as a risk factor for thrombotic disorders.
Localization of ADAMTS13 to the stellate cells of human liver.
Results suggest that HSCs may be major cells producing ADAMTS13 in human liver, with positive signals exclusively in perisinusoidal cells with irregularly elongated dendritic processes extending between hepatocytes.
SCID-repopulating cell activity of human cord blood-derived CD34- cells assured by intra-bone marrow injection.
The unveiling of this novel class of primitive human CD34(-) SRCs by IBMI will provide a new concept of the hierarchy in the human HSC compartment and has important implications for clinical HSC transplantation as well as for basic research of HSC.
A 28 kDa-protein with disintegrin-like structure (jararhagin-C) purified from Bothrops jararaca venom inhibits collagen- and ADP-induced platelet aggregation.
A 28 kDa-protein with inhibitory activity on collagen- and ADP-induced platelet aggregation was purified from the venom of the snake Bothrops jararaca and sequence homology of the protein to other disintegrins and disintegrin-like proteins from various snake venoms is presented.
VWF73, a region from D1596 to R1668 of von Willebrand factor, provides a minimal substrate for ADAMTS-13.
ADAMTS-13 was recently identified as a new hemostatic factor, von Willebrand factor (VWF)-cleaving protease, and data suggested that a minimal region as a functional substrate consisted of 73 amino acid residues from D1596 to R1668 of VWF, designated VWF73, and that further deletion of the E1660-R1668 region led to the loss of cleavage by ADAMts-13.
Increased plasma levels of adrenomedullin in patients with systemic inflammatory response syndrome.
The plasma levels of adrenomedullin (AM) and IL-8 levels correlated positively with Acute Physiology and Chronic Health Evaluation (APACHE) II score, peak multiple organ failure (MOF) score during the first month and prognosis in patients with septic shock, as did plasma IL-6 levels in Patients with traumatic shock.
Novel monoclonal antibody‐based enzyme immunoassay for determining plasma levels of ADAMTS13 activity
A unique and highly sensitive enzyme immunoassay (EIA) of ADAMTS13 activity is described and is described as a prerequisite for a differential diagnosis of thrombotic microangiopathies.
Pregnancy‐induced thrombocytopenia and TTP, and the risk of fetal death, in Upshaw–Schulman syndrome: a series of 15 pregnancies in 9 genotyped patients
Nine women diagnosed with Upshaw–Schulman syndrome who were diagnosed during their first pregnancy had severely deficient ADAMTS13 activity, emphasizing the importance of measuring ADAMts13 activity in the evaluation of thrombocytopenia during childhood and pregnancy.