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Passage of Inhaled Particles Into the Blood Circulation in Humans
Background—Pollution by particulates has been consistently associated with increased cardiovascular morbidity and mortality. However, the mechanisms responsible for these effects are notExpand
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Passage of intratracheally instilled ultrafine particles from the lung into the systemic circulation in hamster.
The mechanisms of particulate pollution-related cardiovascular morbidity and mortality are not well understood. We studied the passage of radioactively labeled ultrafine particles after theirExpand
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Expert position paper on air pollution and cardiovascular disease.
Air pollution has wide-ranging and deleterious effects on human health and is a major issue for the global community. The Global Burden of Disease study has described the worldwide impact of airExpand
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Role of Gas6 receptors in platelet signaling during thrombus stabilization and implications for antithrombotic therapy.
Mechanisms regulating thrombus stabilization remain largely unknown. Here, we report that loss of any 1 of the Gas6 receptors (Gas6-Rs), i.e., Tyro3, Axl, or Mer, or delivery of a solubleExpand
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Kinetics of the activation of plasminogen by human tissue plasminogen activator. Role of fibrin.
The kinetics of the activation of Glu-plasminogen and Lys-plasminogen (P) by a two-chain form of human tissue plasminogen activator (A) were studied in purified systems, and in the presence ofExpand
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Diesel Exhaust Particles in Lung Acutely Enhance Experimental Peripheral Thrombosis
Background—Pollution by particulates has consistently been associated with increased cardiovascular morbidity and mortality, but a plausible biological basis for this association is lacking. MethodsExpand
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Platelet characteristics in patients with X-linked macrothrombocytopenia because of a novel GATA1 mutation.
A new mutation is described in the X-linked gene GATA1, resulting in macrothrombocytopenia and mild dyserythropoietic features but no marked anemia in a 4-generation family. The molecular basis forExpand
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Size effect of intratracheally instilled particles on pulmonary inflammation and vascular thrombosis.
Particulate air pollution is associated with cardiorespiratory effects and ultrafine particles (UFPs, diameter < 100 nm) are believed to play an important role. We studied the acute (1 h) effect ofExpand
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Ultrafine particles affect experimental thrombosis in an in vivo hamster model.
Particulate air pollution is associated with cardiovascular morbidity and mortality. To investigate this association, we studied the effect of ultrafine (60 nm) polystyrene particles on thrombusExpand
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Pulmonary inflammation and thrombogenicity caused by diesel particles in hamsters: role of histamine.
Short-term increases in particulate air pollution are associated with increased incidence of cardiovascular events. Previously, we showed that intratracheally instilled diesel exhaust particlesExpand
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