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bosentan

Known as: 4-(1,1-Dimethylethyl)-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-(2,2'-bipyrimidin)-4-yl)benzenesulfornamide, bosentán, 4-(1,1-Dimethylethyl)-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-(2,2'-bipyrimidin)-4-yl) benzenesulfornamide 
A sulfonamide-derived, competitive and specific endothelin receptor antagonist with a slightly higher affinity for the endothelin A receptor than… 
National Institutes of Health

Related topics

Related topics

13 relations

Broader (3)

Antihypertensive AgentsEndothelin receptor antagonistSulfonamides
CyclosporineDecreased Blood Pressure [PE]GlyburideHypersensitivity

Narrower (2)

Tracleerbosentan monohydrate

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2010
2010
Safe Treatment of Pulmonary Hypertension With Bosentan in a Patient With Moyamoya Disease and Cerebral Ischemia
A 7-year-old girl with Down syndrome and moderately severe pulmonary hypertension experienced a stroke while being treated with a… 
2008
2008
Utilidad del bosentan en la hipertensión pulmonar tromboembólica crónica: Estudio BENEFIT
Disponible en http://www.insuficienciacardiaca.org Rev Insuf Cardíaca 2008; (Vol 3) 2:63-64 La mortalidad a 5 años de la… 
2007
2007
Bosentan therapy for chronic thromboembolic pulmonary hypertension
a Clinics of Internal Medicine, University Hospital, Zurich, Switzerland b Clinic of Pulmonology, University Hospital, Zurich… 
2007
2007
Efectividad del bosentán en el tratamiento de la hipertensión pulmonar debida a tromboembolia venosa crónica
Fundamento y objetivo: La hipertension pulmonar cronica causada por tromboembolia (HTPTEC) sin trombos centrales que permitan la… 
2004
2004
Interspecies Scaling of Bosentan, A New Endothelin Receptor Antagonist and Integration of in Vitro Data into Allometric Scaling
AbstractPurpose. The goal of this study was to find a rational and reliable method of using animal data to predict the clearance… 
2001
2001
Bosentan: Rec INN; USAN
The condensation of diethyl (2-methoxyphenoxy)malonate (I) with pyrimidine-2-carboxamidine (II) by means of NaOMe (Na in MeOH… 
1996
1996
Mutational analysis of the endothelin type A receptor (ETA): interactions and model of selective ETA antagonist BMS-182874 with putative ETA receptor binding cavity.
Endothelin (ET) receptor antagonism is a potential therapeutic intervention in the treatment of vascular diseases. To elucidate… 
Review
1996
Review
1996
Is there a role for endothelin in the natural history of heart failure?
A role for locally released and circulating peptides in the progressive syndrome of heart failure has been widely entertained… 
1995
1995
Protective Effects of the Mixed Endothelin Receptor Antagonist Bosentan in Rats with CCL4‐Induced Liver Injury
Summary: We determined whether the paracrine liver endothelin (ET) system participates in the pathogenesis of CCl4-induced… 
1995
1995
Significance of Endothelin Receptor Subtypes in the Kidneys of Spontaneously Hypertensive Rats: Renal and Hemodynamic Effects of Endothelin Receptor Antagonists
Summary: The renal endothelin (ET) system has been implicated in the maintenance of hypertension in spontaneously hypertensive… 
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