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bosentan

Known as: 4-(1,1-Dimethylethyl)-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-(2,2'-bipyrimidin)-4-yl)benzenesulfornamide, bosentán, 4-(1,1-Dimethylethyl)-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-(2,2'-bipyrimidin)-4-yl) benzenesulfornamide 
A sulfonamide-derived, competitive and specific endothelin receptor antagonist with a slightly higher affinity for the endothelin A receptor than… Expand
National Institutes of Health

Papers overview

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Highly Cited
2011
Highly Cited
2011
RATIONALE A previous trial of bosentan in idiopathic pulmonary fibrosis (IPF) showed a trend to delayed IPF worsening or death… Expand
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Highly Cited
2008
Highly Cited
2008
BACKGROUND Treatments for pulmonary arterial hypertension have been mainly studied in patients with advanced disease (WHO… Expand
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Highly Cited
2008
Highly Cited
2008
OBJECTIVES Our goal was to investigate the effect of treatment with the oral dual endothelin receptor antagonist bosentan on the… Expand
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Highly Cited
2006
Highly Cited
2006
BACKGROUND Eisenmenger syndrome is characterized by the development of pulmonary arterial hypertension with consequent… Expand
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Highly Cited
2006
Highly Cited
2006
RATIONALE Small, open-label studies suggest that combinations of existing therapies may be effective for pulmonary arterial… Expand
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Highly Cited
2005
Highly Cited
2005
Primary pulmonary hypertension (PPH) is a progressive disease with high mortality. Administration of i.v. epoprostenol has… Expand
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Highly Cited
2004
Highly Cited
2004
The efficacy and safety of combining bosentan, an orally active dual endothelin receptor antagonist and epoprostenol, a… Expand
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Highly Cited
2004
Highly Cited
2004
OBJECTIVE Recurrent digital ulcers are a manifestation of vascular disease in patients with systemic sclerosis (SSc; scleroderma… Expand
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Highly Cited
2002
Highly Cited
2002
  • Avid, B. B., +15 authors NDOTHELIN
  • 2002
  • Corpus ID: 12285387
A BSTRACT Background Endothelin-1 is a potent vasoconstrictor and smooth-muscle mitogen. In a preliminary study, the orally… Expand
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Highly Cited
2001
Highly Cited
2001
BACKGROUND Endothelin 1, a powerful endogenous vasoconstrictor and mitogen, might be a cause of pulmonary hypertension. We… Expand
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