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bosentan

Known as: 4-(1,1-Dimethylethyl)-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-(2,2'-bipyrimidin)-4-yl)benzenesulfornamide, bosentán, 4-(1,1-Dimethylethyl)-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-(2,2'-bipyrimidin)-4-yl) benzenesulfornamide 
A sulfonamide-derived, competitive and specific endothelin receptor antagonist with a slightly higher affinity for the endothelin A receptor than… 
National Institutes of Health

Related topics

Related topics

13 relations

Broader (3)

Antihypertensive AgentsEndothelin receptor antagonistSulfonamides
CyclosporineDecreased Blood Pressure [PE]GlyburideHypersensitivity

Narrower (2)

Tracleerbosentan monohydrate

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2013
2013
VALIDATED STABILITY INDICATING RP-HPLC METHOD FOR THE DETERMINATION OF BOSENTAN IN PRESENCE OF DEGRADATION PRODUCTS
Article history A simple, specific and sensitive stability-indicating high-performance liquid chromatographic method was… 
2009
2009
Six-Minute Walk Test in Scleroderma-Associated Pulmonary Arterial Hypertension: Are We Counting What Counts?
> Everything that can be counted does not necessarily count; > > Everything that counts cannot necessarily be counted… 
2008
2008
Utilidad del bosentan en la hipertensión pulmonar tromboembólica crónica: Estudio BENEFIT
Disponible en http://www.insuficienciacardiaca.org Rev Insuf Cardíaca 2008; (Vol 3) 2:63-64 La mortalidad a 5 años de la… 
2008
2008
Treating pulmonary hypertension in COPD: where do we start?
Endothelin receptor antagonists, phosphodiesterase (PDE)-5 inhibitors and prostanoids are effective treatments for pulmonary… 
2007
2007
Efectividad del bosentán en el tratamiento de la hipertensión pulmonar debida a tromboembolia venosa crónica
Fundamento y objetivo: La hipertension pulmonar cronica causada por tromboembolia (HTPTEC) sin trombos centrales que permitan la… 
2006
2006
Bosentan may induce arthritis flare in patients with scleroderma concomitantly treated with methotrexate
In recent years, endothelin receptor antagonism has emerged as an important therapeutic strategy for pulmonary arterial… 
2005
2005
PHARMAC not funding some treatments for rare, life-threatening diseases: bosentan as an example.
  • K. Whyte
  • The New Zealand medical journal
  • 2005
  • Corpus ID: 20879168
Pulmonary arterial hypertension is a devastating and fatal disease for which effective therapies have been developed over the… 
2001
2001
Bosentan: Rec INN; USAN
The condensation of diethyl (2-methoxyphenoxy)malonate (I) with pyrimidine-2-carboxamidine (II) by means of NaOMe (Na in MeOH… 
Review
1996
Review
1996
Is there a role for endothelin in the natural history of heart failure?
A role for locally released and circulating peptides in the progressive syndrome of heart failure has been widely entertained… 
1995
1995
Protective Effects of the Mixed Endothelin Receptor Antagonist Bosentan in Rats with CCL4‐Induced Liver Injury
Summary: We determined whether the paracrine liver endothelin (ET) system participates in the pathogenesis of CCl4-induced…