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Cyclosporine

Known as: Ciclosporine, Ciclosporin, CyA 
A natural cyclic polypeptide immunosuppressant isolated from the fungus Beauveria nivea. The exact mechanism of action of cyclosporine is not known… 
National Institutes of Health

Related topics

Related topics

40 relations

Narrower (10)

(melle-4)cyclosporinAtopicaIminoralNeoral
Cyclosporine 0.5 MG/ML Ophthalmic Suspension [Restasis]Cyclosporine 25 MG Oral Capsule [Sandimmune]Cyclosporine:MCnc:Pt:Bld:Qn:IACyclosporine:Mass:Pt:Dose:Qn

Broader (3)

Dermatologic AgentsEnzyme InhibitorsImmunosuppressive Agents

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2006
Highly Cited
2006
Significant improvement in the outcome of HCV-infected transplant recipients by avoiding rapid steroid tapering and potent induction immunosuppression.
Highly Cited
2005
Highly Cited
2005
Alemtuzumab (CAMPATH 1H) Induction Therapy in Cadaveric Kidney Transplantation—Efficacy and Safety at Five Years
Alemtuzumab is a powerful lymphocyte depleting antibody currently being evaluated in solid organ transplantation. This paper… 
Highly Cited
2005
Highly Cited
2005
Long-term results in renal transplant patients with allograft dysfunction after switching from calcineurin inhibitors to sirolimus.
BACKGROUND Switching from calcineurin inhibitors (CNIs) to sirolimus might improve renal function in chronic renal transplant… 
Highly Cited
1996
Highly Cited
1996
Anisotropic rotational diffusion of perdeuterated HIV protease from 15N NMR relaxation measurements at two magnetic fields
Summary15N NMR relaxation times in perdeuterated HIV-1 protease, complexed with the sub-nanomolar inhibitor DMP323, have been… 
Highly Cited
1995
Highly Cited
1995
B-cell activation by crosslinking of surface IgM or ligation of CD40 involves alternative signal pathways and results in different B-cell phenotypes.
Treatment of small resting B cells with soluble F(ab')2 fragments of anti-IgM, an analogue of T-independent type 2 antigens… 
Highly Cited
1993
Highly Cited
1993
Identification of a novel cyclosporin-sensitive element in the human tumor necrosis factor alpha gene promoter
Tumor necrosis factor alpha (TNF-alpha), a cytokine with pleiotropic biological effects, is produced by a variety of cell types… 
Highly Cited
1992
Highly Cited
1992
Calcineurin mediates inhibition by FK506 and cyclosporin of recovery from α-factor arrest in yeast
THE structurally unrelated immunosuppressants FK506 and cyclosporin A (CsA) act similarly, inhibiting a Ca2+-dependent signal… 
Highly Cited
1990
Highly Cited
1990
Low-dose cyclosporin versus placebo in patients with rheumatoid arthritis
Highly Cited
1989
Highly Cited
1989
The effect of cyclosporin A administration and its withdrawal on bone mineral metabolism in the rat.
The in vivo administration of cyclosporin A (CsA) has been associated with significant bone loss and increased bone remodeling… 
Highly Cited
1989
Highly Cited
1989
Chemosensitivity testing of fresh leukaemia cells using the MTT colorimetric assay
We have determined the feasibility of using the MTT colorimetric assay for measuring the sensitivity of fresh leukaemia cells to… 
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