• Publications
  • Influence
IL-10-producing and naturally occurring CD4+ Tregs: limiting collateral damage.
Effective immune responses against pathogens are sometimes accompanied by strong inflammatory reactions. To minimize damage to self, the activation of the immune system also triggersExpand
  • 492
  • 29
Earlier versus later start of antiretroviral therapy in HIV-infected adults with tuberculosis.
BACKGROUND Tuberculosis remains an important cause of death among patients infected with the human immunodeficiency virus (HIV). Robust data are lacking with regard to the timing for the initiationExpand
  • 559
  • 26
A Lipopolysaccharide-Specific Enhancer Complex Involving Ets, Elk-1, Sp1, and CREB Binding Protein and p300 Is Recruited to the Tumor Necrosis Factor Alpha Promoter In Vivo
ABSTRACT The tumor necrosis factor alpha (TNF-α) gene is rapidly activated by lipopolysaccharide (LPS). Here, we show that extracellular signal-regulated kinase (ERK) kinase activity but notExpand
  • 281
  • 21
Tumor necrosis factor alpha gene regulation in activated T cells involves ATF-2/Jun and NFATp.
The human tumor necrosis factor alpha (TNF-alpha) gene is one of the earliest genes expressed upon the activation of a T or B cell through its antigen receptor. Previous experiments have demonstratedExpand
  • 241
  • 19
IL-10-producing T cells suppress immune responses in anergic tuberculosis patients.
The lethality of Mycobacterium tuberculosis remains the highest among infectious organisms and is linked to inadequate immune response of the host. Containment and cure of tuberculosis requires anExpand
  • 412
  • 16
Ethnic-specific genetic associations with pulmonary tuberculosis.
Several susceptibility-associated genetic polymorphisms have been proposed to explain differential susceptibility to tuberculosis (TB) disease progression in different populations. Here,Expand
  • 266
  • 16
Stimulus-Specific Assembly of Enhancer Complexes on the Tumor Necrosis Factor Alpha Gene Promoter
ABSTRACT The human tumor necrosis factor alpha (TNF-α) gene is rapidly activated in response to multiple signals of stress and inflammation. We have identified transcription factors present in theExpand
  • 172
  • 15
Control of HIV-1 viremia and protection from AIDS are associated with HLA-Bw4 homozygosity
Certain HLA-B antigens have been associated with lack of progression to AIDS. HLA-B alleles can be divided into two mutually exclusive groups based on the expression of the molecular epitopes HLA-Bw4Expand
  • 246
  • 13
Transcriptional control of the TNF gene.
The cytokine TNF is a critical mediator of immune and inflammatory responses. The TNF gene is an immediate early gene, rapidly transcribed in a variety of cell types following exposure to a broadExpand
  • 140
  • 13
Involvement of Bruton's Tyrosine Kinase in FcεRI-dependent Mast Cell Degranulation and Cytokine Production
We investigated the role of Bruton's tyrosine kinase (Btk) in FcεRI-dependent activation of mouse mast cells, using xid and btk null mutant mice. Unlike B cell development, mast cell development isExpand
  • 228
  • 11