FAQ

Endothelin receptor antagonist

Known as: antagonist endothelin receptor, Antagonists, Endothelin, Endothelin Receptor Antagonists 
A family of drugs that block the hormone endothelin and may prevent prostate cancer from spreading to the bones. They may also prevent the growth and… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1996-2017
02419962017

Related topics

Related topics

37 relations

Narrower (31)

A 216546ATZ1993BMS 184696BMS 184697
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In Bloodadministration & dosageaspects of radiation effectschemical synthesis
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Related mentions per year

Related mentions per year

1946-2018
19401960198020002020
Endothelin receptor antagonist
chemical synthesis
bosentan
standards characteristics
atrasentan
sitaxsentan

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2013
2013
Safety, tolerability, pharmacokinetics, and pharmacodynamics of macitentan, an endothelin receptor antagonist, in an ascending multiple-dose study in healthy subjects.
This multiple-ascending-dose study investigated safety, tolerability, pharmacokinetics, and pharmacodynamics, of macitentan, a… (More)
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2012
2012
Slow Receptor Dissociation Kinetics Differentiate Macitentan from Other Endothelin Receptor Antagonists in Pulmonary Arterial Smooth Muscle Cells
Two endothelin receptor antagonists (ERAs), bosentan and ambrisentan, are currently approved for the treatment of pulmonary… (More)
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Highly Cited
2012
Highly Cited
2012
Oral treprostinil for the treatment of pulmonary arterial hypertension in patients on background endothelin receptor antagonist and/or phosphodiesterase type 5 inhibitor therapy (the FREEDOM-C study…
BACKGROUND Infused and inhaled treprostinil are effective for treatment of pulmonary arterial hypertension (PAH), although their… (More)
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2009
2009
Endothelin receptor antagonist and airway dysfunction in pulmonary arterial hypertension
BACKGROUND In idiopathic pulmonary arterial hypertension (IPAH), peripheral airway obstruction is frequent. This is partially… (More)
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Review
2008
Review
2008
[Endothelin receptor antagonist].
Pulmonary arterial hypertension(PAH) is an uncommon disease characterised by a progressive increase in pulmonary vascular… (More)
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2004
2004
Endothelin receptor antagonist reverses decreased NO system in the kidney in vivo during exercise.
Vascular endothelial cells produce endothelin (ET)-1, a potent vasoconstrictor peptide, and nitric oxide (NO), a potent… (More)
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2004
2004
Endothelin receptor antagonist bosentan improves survival in a murine caecal ligation and puncture model of septic shock.
The role of endothelin peptides was evaluated on survival and organ injury in a model of polymicrobial sepsis, induced by caecal… (More)
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2004
2004
Endothelin receptor antagonist TAK-044 arrests and reverses the development of carbon tetrachloride induced cirrhosis in rats.
BACKGROUND AND AIMS Hepatic concentrations of the powerful vasoconstrictor and fibrogen endothelin 1 (ET-1) and its receptors… (More)
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2001
2001
Endothelin receptor antagonist prevents parathyroid cell proliferation of low calcium diet-induced hyperparathyroidism in rats.
Secondary hyperparathyroidism, one of the most frequently encountered disorders of the calcium homeostasis, is characterized by… (More)
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1996
1996
Endothelin receptor antagonist increases cerebral perfusion and reduces ischaemic damage in feline focal cerebral ischaemia.
These investigations characterised the cerebrovascular effects of an endothelin ETA-receptor antagonist PD156707 in normal and… (More)
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