Endothelin receptor antagonist

Known as: antagonist endothelin receptor, Antagonists, Endothelin, Endothelin Receptor Antagonists 
A family of drugs that block the hormone endothelin and may prevent prostate cancer from spreading to the bones. They may also prevent the growth and… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1996-2017
02419962017

Papers overview

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2013
2013
This multiple-ascending-dose study investigated safety, tolerability, pharmacokinetics, and pharmacodynamics, of macitentan, a… (More)
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2012
2012
Two endothelin receptor antagonists (ERAs), bosentan and ambrisentan, are currently approved for the treatment of pulmonary… (More)
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Highly Cited
2012
Highly Cited
2012
BACKGROUND Infused and inhaled treprostinil are effective for treatment of pulmonary arterial hypertension (PAH), although their… (More)
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2009
2009
BACKGROUND In idiopathic pulmonary arterial hypertension (IPAH), peripheral airway obstruction is frequent. This is partially… (More)
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Review
2008
Review
2008
Pulmonary arterial hypertension(PAH) is an uncommon disease characterised by a progressive increase in pulmonary vascular… (More)
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2004
2004
Vascular endothelial cells produce endothelin (ET)-1, a potent vasoconstrictor peptide, and nitric oxide (NO), a potent… (More)
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2004
2004
The role of endothelin peptides was evaluated on survival and organ injury in a model of polymicrobial sepsis, induced by caecal… (More)
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2004
2004
BACKGROUND AND AIMS Hepatic concentrations of the powerful vasoconstrictor and fibrogen endothelin 1 (ET-1) and its receptors… (More)
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2001
2001
Secondary hyperparathyroidism, one of the most frequently encountered disorders of the calcium homeostasis, is characterized by… (More)
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1996
1996
These investigations characterised the cerebrovascular effects of an endothelin ETA-receptor antagonist PD156707 in normal and… (More)
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