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A 216546

Known as: A-216546 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (2)

Endothelin receptor antagonistPyrrolidines

Papers overview

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2000
2000
Effects of endothelin receptor antagonists on the plasma immunoreactive endothelin-1 level.
Endothelin (ET) receptor antagonists may be beneficial for treating several medical conditions. Human trials with various ET… 
Highly Cited
1999
Highly Cited
1999
Endothelin Stimulates Glucose Uptake and GLUT4 Translocation via Activation of Endothelin ETA Receptor in 3T3-L1 Adipocytes*
Endothelin-1 (ET-1) is a 21-amino acid peptide that binds to G-protein-coupled receptors to evoke biological responses. This… 
1999
1999
Pharmacology of A-216546: a highly selective antagonist for endothelin ET(A) receptor.
1998
1998
Pyrrolidine-3-carboxylic acids as endothelin antagonists. 3. Discovery of a potent, 2-nonaryl, highly selective ETA antagonist (A-216546).
Previously we have reported the discovery of ABT-627 (1, A-147627, active enantiomer of A-127722), a 2,4-diaryl substituted… 
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