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Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension.
TLDR
Results provide evidence for the involvement of HIF-1 in O2 homeostasis and represent a functional characterization of the putative O2 sensor that initiates hypoxia signal transduction leading to Hif-1 expression.
Rate of erythropoietin formation in humans in response to acute hypobaric hypoxia.
TLDR
EPO levels during hypoxia were significantly elevated after 114 and 84 min (3,000 and 4,000 m) and rising thereafter continuously for the period investigated, corresponding to 1.8-fold and 3.0-fold increases in the calculated production rate of the hormone.
HIF-1-induced erythropoietin in the hypoxic retina protects against light-induced retinal degeneration
TLDR
It is shown in the adult mouse retina that acute hypoxia dose-dependently stimulates expression of Epo, fibroblast growth factor 2 and vascular endothelial growth factor via Hypoxia-inducible factor-1α (HIF-1 α) stabilization.
Erythropoietin Gene Expression in Human, Monkey and Murine Brain
TLDR
It is shown that cerebral erythropoietin and its receptor are expressed in the brain of primates as they are in rodents, and that, at least in mice, primary astrocytes are a source of cerebral eriespheric expression which can be up‐regulated by reduced oxygenation.
Induction of HIF–1α in response to hypoxia is instantaneous
TLDR
The instant initiation of HIF‐1α accumulation shown here limits the hypoxic signaling pathway to below 2 min, and a number of redox‐sensitive nuclear factors over a range of pathophysiological oxygen concentrations are determined.
Endothelin-1 transgenic mice develop glomerulosclerosis, interstitial fibrosis, and renal cysts but not hypertension.
TLDR
These transgenic lines provide a new blood pressure-independent animal model of ET-1-induced renal pathology leading to renal fibrosis and fatal kidney disease.
Nitric oxide prevents cardiovascular disease and determines survival in polyglobulic mice overexpressing erythropoietin.
TLDR
It is unequivocally demonstrated that endothelial NO maintains normotension, prevents cardiovascular dysfunction, and critically determines survival in vivo under conditions of increased hematocrit.
Localization of specific erythropoietin binding sites in defined areas of the mouse brain.
TLDR
Functional expression of the EPO-R and hypoxic upregulation of EPO suggest a role ofEPO in the brain, and defined binding sites for radioiodinated EPO in distinct brain areas are revealed.
Mechanisms of Suicidal Erythrocyte Death
TLDR
Erythrocyte shrinkage and phosphatidylserine exposure (‘eryptosis’) mimic features of apoptosis in nucleated cells which however, involves several mechanisms lacking in erythrocytes.
Causes of high blood O2 affinity of animals living at high altitude.
TLDR
It is concluded that the hemoglobin of the bar-headed goose reacts more weakly with organic phosphates, which can be inferred from studies on purified hemoglobin solutions, and the low P50 of Guanaco blood in comparison with human blood can be explained by a reduced interaction of 2,3-bisphosphoglycerate of guanaco hemoglobin compared to the human pigment.
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