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bispecific antibody 2B1
Known as:
MoAb 2B1 Bispecific
, 2B1 Bispecific Murine MAb
, BsAb 2B1
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A monoclonal antibody with potential antineoplastic activity. Specific for both the immunoglobulin G (IgG) receptor CD16 and c-erbB-2, bispecific…
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National Institutes of Health
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Related topics
Related topics
8 relations
Broader (1)
Antibodies, Bispecific
Antigens, CD16
Bispecific Monoclonal Antibodies
ERBB2 protein, human
NCIt Antineoplastic Agent Terminology
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2015
Highly Cited
2015
The preclinical pharmacology of the high affinity anti-IL-6R Nanobody® ALX-0061 supports its clinical development in rheumatoid arthritis
M. van Roy
,
C. Ververken
,
+11 authors
H. Ulrichts
Arthritis Research & Therapy
2015
Corpus ID: 5571390
IntroductionThe pleiotropic cytokine interleukin-6 (IL-6) plays an important role in the pathogenesis of different diseases…
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Highly Cited
1998
Highly Cited
1998
Peroxynitrite-mediated nitration of tyrosine and inactivation of the catalytic activity of cytochrome P450 2B1.
E. S. Roberts
,
H. Lin
,
J. Crowley
,
J. Vuletich
,
Y. Osawa
,
P. Hollenberg
Chemical Research in Toxicology
1998
Corpus ID: 1291551
The addition of peroxynitrite to purified cytochrome P450 2B1 resulted in a concentration-dependent loss of the NADPH- and…
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Highly Cited
1998
Highly Cited
1998
Bispecific molecules directed to the Fc receptor for IgA (Fc alpha RI, CD89) and tumor antigens efficiently promote cell-mediated cytotoxicity of tumor targets in whole blood.
Y. Deo
,
K. Sundarapandiyan
,
T. Keler
,
P. Wallace
,
R. Graziano
Journal of Immunology
1998
Corpus ID: 24215590
The FcR for IgA (Fc alpha RI, CD89) is primarily expressed on cytotoxic immune effector cells. By chemically cross-linking F(ab…
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Highly Cited
1997
Highly Cited
1997
Retargeting serum immunoglobulin with bispecific diabodies
P. Holliger
,
M. Wing
,
J. Pound
,
H. Bohlen
,
G. Winter
Nature Biotechnology
1997
Corpus ID: 23522663
Monospecific antibody fragments produced in bacteria lack the Fc portion of antibodies, and are therefore unable to recruit…
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Highly Cited
1996
Highly Cited
1996
Gene therapy for malignant gliomas using replication incompetent retroviral and adenoviral vectors encoding the cytochrome P450 2B1 gene together with cyclophosphamide.
Y. Manome
,
P. Wen
,
+6 authors
H. Fine
Gene Therapy
1996
Corpus ID: 2967790
Cyclophosphamide is an inactive prodrug which is converted by hepatic cytochrome P450 2B1 to cytotoxic metabolites which produce…
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Highly Cited
1995
Highly Cited
1995
Phase I Trial of 2B1, a Bispecific Monoclonal Antibody Targeting c-erbB-2 and FcγRIII
L. Weiner
,
J. Clark
,
+4 authors
R. Alpaugh
1995
Corpus ID: 72951861
Abstract 2B1 is a bispecific murine monoclonal antibody (BsMAb) with specificity for the c-erbB-2 and FcγRIII extracellular…
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Highly Cited
1995
Highly Cited
1995
Phase I trial of 2B1, a bispecific monoclonal antibody targeting c-erbB-2 and Fc gamma RIII.
L. Weiner
,
J. Clark
,
+4 authors
R. Alpaugh
Cancer Research
1995
Corpus ID: 23736255
2B1 is a bispecific murine monoclonal antibody (BsMAb) with specificity for the c-erbB-2 and Fc gamma RIII extracellular domains…
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Highly Cited
1995
Highly Cited
1995
Clinical development of 2B1, a bispecific murine monoclonal antibody targeting c-erbB-2 and Fc gamma RIII.
L. Weiner
,
J. Clark
,
D. Ring
,
R. Alpaugh
Journal of Hematotherapy
1995
Corpus ID: 25159426
Bispecific monoclonal antibodies (BsmAb) can be used to specifically target tumor cells for cytotoxicity mediated by defined…
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Highly Cited
1993
Highly Cited
1993
Binding and cytotoxicity characteristics of the bispecific murine monoclonal antibody 2B1.
L. Weiner
,
M. Holmes
,
+5 authors
R. Alpaugh
Journal of Immunology
1993
Corpus ID: 30441206
Bispecific monoclonal antibodies (BsmAb) with specificity for tumor Ag and effector cell trigger molecules have been shown to…
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1993
1993
Delivery of saporin to human B-cell lymphoma using bispecific antibody: targeting via CD22 but not CD19, CD37, or immunoglobulin results in efficient killing.
M. Bonardi
,
R. French
,
P. Amlot
,
G. Gromo
,
D. Modena
,
M. Glennie
Cancer Research
1993
Corpus ID: 6494158
A panel of bispecific F(ab')2 antibodies (BsAb) have been constructed for delivering the ribosome-inactivating protein saporin to…
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