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IgE to Bet v 1 and profilin: cross-reactivity patterns and clinical relevance.
IgE antibodies against Bet v 1 have a more limited spectrum of cross-reactivity than those against profilin, but they frequently give rise to clinically relevantCross-reactivities to food.
Fluorescence in situ hybridization analysis shows the frequent occurrence of 14q32.3 rearrangements with involvement of immunoglobulin switch regions in myeloma cell lines.
The almost ubiquitous presence of 14q32.3 chromosomal rearrangements suggests an obligatory role in the development of myeloma and the high incidence of breakpoints involving switch regions indicates an oncogenic event in a late stage of B-cell differentiation.
The HB-6, CDw75, and CD76 differentiation antigens are unique cell- surface carbohydrate determinants generated by the beta-galactoside alpha 2,6-sialyltransferase
Results indicate thatalpha 2,6-ST expression is a critical regulatory step in the formation of the Ags that are recognized by these mAb, and that an alpha 2, 6-linked sialic acid residue is an essential component of each Ag.
Clinical experience with CD3 x CD19 bispecific antibodies in patients with B cell malignancies.
Intravenously administered BsAb in an intrapatient dose escalation study of 3 patients with B cell non-Hodgkin's lymphoma showed limited toxicity (WHO grade II fever and chills) due to tumor necrosis factor-alpha (TNF-alpha) release by T cells, and treatment of patients with a lower tumor load seems to be warranted to evaluate the efficacy of CD3 x CD19 Bs Ab therapy.
Enrichment and selection of hybrid hybridomas by Percoll density gradient centrifugation and fluorescent-activated cell sorting.
There was an 8-fold increase of total isolated hybrid hybridomas (up to 30% of all tested clones) compared to isolations without Percoll density gradient centrifugation, and the number of double-fluorescent fused cells had similar amounts of DNA.
Clinical perspectives of bispecific antibodies in cancer
A personal perspective on the treatment of cancer, in which the choice of both the effector cells and the target antigen is of major importance, is given.
Syngeneic leukocytes together with suramin failed to improve immunodeficiency in a case of transfusion-associated AIDS after syngeneic bone marrow transplantation
A 22-year-old man who underwent syngeneic bone marrow transplantation (BMT) for acute lymphoblastic leukemia acquired a human immunodeficiency virus (HIV) infection by transfusion of blood products
The recurrent translocation t(14;20)(q32;q12) in multiple myeloma results in aberrant expression of MAFB: a molecular and genetic analysis of the chromosomal breakpoint
Chromosomal translocations of the immunoglobulin heavy chain (IgH) gene region at 14q32 are regularly involved in B lymphoid malignancies; they may initiate transformation either by deregulation of
Killing of autologous B-lineage malignancy using CD3 x CD19 bispecific monoclonal antibody in end stage leukemia and lymphoma.
Various types of experiments showed that efficient CD3 x CD19 BsAb-mediated cytolytic capacity was not dependent on expression of either of these surface proteins, which contrasts with normal major histocompatibility complex-restricted antigen-specific cytotoxicity and may be essential for effective in vivo application of this Bs Ab.