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The Histone Deacetylase Inhibitor ITF2357 Reduces Production of Pro-Inflammatory Cytokines In Vitro and Systemic Inflammation In Vivo
Low, nonapoptotic concentrations of the HDAC inhibitor ITF2357 reduce pro-inflammatory cytokine production in primary cells in vitro and exhibit anti-inflammatory effects in vivo.
Pharmacokinetics, Safety and Inducible Cytokine Responses during a Phase 1 Trial of the Oral Histone Deacetylase Inhibitor ITF2357 (Givinostat)
It is concluded that dosing of 50 or 100 mg ITF2357 is safe in healthy humans and transiently but repeatedly reduces the production of proinflammatory cytokines without affecting production of anti inflammatory cytokines.
Specific Inhibition of Histone Deacetylase 8 Reduces Gene Expression and Production of Proinflammatory Cytokines in Vitro and in Vivo*
- Suzhao Li, G. Fossati, C. Dinarello
- Biology, MedicineThe Journal of Biological Chemistry
- 1 December 2014
The data suggest that specific inhibition of HDAC8 results in reduced inflammation without cell toxicity, which is preferred for treating inflammatory diseases, with fewer side effects.
Transcriptional control of glucoamylase synthesis in vegetatively growing and sporulating Saccharomyces species
- I. Pretorius, D. Modena, M. Vanoni, S. Englard, J. Marmur
- Medicine, BiologyMolecular and cellular biology
- 1 September 1986
It was found that STA2 strains grown in synthetic medium produce glucoamylase only in the presence of either Maltrin M365 (a mixture of maltooligosaccharides) or starch, and the same mRNA species was detected in sporulating sta0 diploids and is likely to encode the sporulation-specific glu CoAmylase.
Molecular cloning and characterization of the STA2 glucoamylase gene of Saccharomyces diastaticus
Southern blot analysis using BamHI digested genomic DNA from 15 tetrads demonstrated consistent co-segregation and Mendelian inheritance of the Sta− phenotype with STA2::URA3, confirming that the cloned DNA that showed Sta+ complementing activity carries a functional STA2 gene that encodes the yeast extracellular glucoamylase II.
Delivery of saporin to human B-cell lymphoma using bispecific antibody: targeting via CD22 but not CD19, CD37, or immunoglobulin results in efficient killing.
- M. Bonardi, R. French, P. Amlot, G. Gromo, D. Modena, M. Glennie
- Biology, ChemistryCancer research
- 1 July 1993
Results suggest that selected combinations of BsAb which bind cooperatively to a toxin and the cell surface may provide an efficient way of delivering toxins to unwanted cells in patients.
Biochemical and immunological characterization of the STA2-encoded extracellular glucoamylase from saccharomyces diastaticus.
Identification and cloning of human chaperonin 10 homologue.
Preventive administration of Mycobacterium tuberculosis 10-kDa heat shock protein (hsp10) suppresses adjuvant arthritis in Lewis rats.
Expression and activity of pre-dianthin 30 and dianthin 30.
- G. Legname, G. Gromo, J. Lord, N. Monzini, D. Modena
- BiologyBiochemical and biophysical research…
- 14 May 1993
Specific PCR amplifications of either the full length pre-dianthin 30 or dianthin30, the mature polypeptide lacking the 23 amino acid signal peptide are described, confirming the characteristics of the natural product.