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Antibodies, Bispecific

Known as: Bispecific Antibody, Bispecific Antibodies, bsAb 
Antibodies, often monoclonal, in which the two antigen-binding sites are specific for separate ANTIGENIC DETERMINANTS. They are artificial antibodies… 
National Institutes of Health

Related topics

Related topics

20 relations

Narrower (12)

AMG 330Bi20 antibodyBispecific Monoclonal AntibodiesMDX-H210 antibody
Antibody SpecificityImmunologic CytotoxicityImmunotoxinsIn Blood

Broader (1)

Immunologic Factors

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2012
Highly Cited
2012
Anti‐CD3 × anti‐GD2 bispecific antibody redirects T‐cell cytolytic activity to neuroblastoma targets
The ganglioside GD2 is an attractive target for immunotherapy of neuroectodermal tumors. We tested a unique bispecific antibody… 
Review
2003
Review
2003
Bispecific antibodies for polyclonal T-cell engagement.
Single-chain bispecific antibodies are emerging as an extremely powerful and promising class of polyclonal T-cell-engaging… 
Review
2002
Review
2002
Bispecific antibodies targeting cancer cells.
In recent years, antibody therapy has become a new treatment modality for tumour patients, although the majority of responses are… 
Highly Cited
2000
Highly Cited
2000
Therapeutic efficacy of FcgammaRI/CD64-directed bispecific antibodies in B-cell lymphoma.
CD64 (FcgammaRI) receptors represent highly potent trigger molecules for activated polymorphonuclear cells (PMN) and mediate… 
Highly Cited
1996
Highly Cited
1996
High Level Secretion of a Humanized Bispecific Diabody from Escherichia coli
Clinical development of bispecific antibodies (BsAb) has been effectively stymied by the lack of efficient production methods. We… 
Highly Cited
1996
Highly Cited
1996
Phage diabody repertoires for selection of large numbers of bispecific antibody fragments
Methods for the generation of large numbers of different bispecific antibodies are presented. Cloning strategies are detailed to… 
1995
1995
Bispecific antibody targeted T cell therapy of ovarian cancer: clinical results and future directions.
The high frequency of relapse after induction chemotherapy in advanced ovarian carcinoma patients calls for new therapeutic… 
Highly Cited
1993
Highly Cited
1993
Lysis of malignant B cells from patients with B-chronic lymphocytic leukemia by autologous T cells activated with CD3 x CD19 bispecific antibodies in combination with bivalent CD28 antibodies.
Bispecific antibodies (bi-MABs) can be used to target T cells to autologous tumor cells. It has been shown that the activation of… 
Highly Cited
1991
Highly Cited
1991
Treatment of murine B cell lymphoma with bispecific monoclonal antibodies (anti-idiotype x anti-CD3).
It has previously been reported that T lymphocytes can be targeted by using bispecific antibodies consisting of anti-target… 
Highly Cited
1990
Highly Cited
1990
Enhanced antigen immunogenicity induced by bispecific antibodies
The binding of protein antigens to APC with heterocrosslinked bispecific antibodies (HBAs) enhances their processing and… 
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