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Antibodies, Bispecific

Known as: Bispecific Antibody, Bispecific Antibodies, bsAb 
Antibodies, often monoclonal, in which the two antigen-binding sites are specific for separate ANTIGENIC DETERMINANTS. They are artificial antibodies… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2017
Review
2017
ABSTRACT During the past two decades we have seen a phenomenal evolution of bispecific antibodies for therapeutic applications… Expand
Review
2015
Review
2015
Bispecific antibodies are on the cusp of coming of age as therapeutics more than half a century after they were first described… Expand
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Review
2012
Review
2012
Monoclonal antibodies are widely used for the treatment of cancer, inflammatory and infectious diseases and other disorders. Most… Expand
Highly Cited
2011
Highly Cited
2011
We describe a generic approach to assemble correctly two heavy and two light chains, derived from two existing antibodies, to… Expand
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Review
2009
Review
2009
  • P. Chames, D. Baty
  • Current opinion in drug discovery & development
  • 2009
  • Corpus ID: 23528594
With 23 approvals in the US and other countries and 4 approvals outside US, antibodies are now widely recognized as therapeutic… Expand
Review
2005
Review
2005
Bispecific T-cell engager molecules (BiTEs) constitute a class of bispecific single-chain antibodies for the polyclonal… Expand
Highly Cited
2002
Highly Cited
2002
A recent study reported on an anti‐CD19/anti‐CD3 single‐chain bispecific antibody (bscCD19xCD3) exhibiting high activity against… Expand
Highly Cited
2000
Highly Cited
2000
Although bispecific antibodies directed against malignant lymphoma have been shown to be effective in vitro and in vivo, extended… Expand
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Highly Cited
1995
Highly Cited
1995
Construction of a bispecific single-chain antibody derivative is described that consists of two different single-chain Fv… Expand
Highly Cited
1993
Highly Cited
1993
Bivalent and bispecific antibodies and their fragments have immense potential for practical application. Here we describe the… Expand
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