Antibodies, Bispecific

Known as: Bispecific Antibody, Bispecific Antibodies, bsAb 
Antibodies, often monoclonal, in which the two antigen-binding sites are specific for separate ANTIGENIC DETERMINANTS. They are artificial antibodies… (More)
National Institutes of Health

Papers overview

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Review
2017
Review
2017
During the past two decades we have seen a phenomenal evolution of bispecific antibodies for therapeutic applications. The 'zoo… (More)
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Review
2017
Review
2017
Pharmacological and cellular treatment of cancer is changing dramatically with benefits for patient outcome and comfort, but also… (More)
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Review
2017
Review
2017
During the past two decades, a great evolution of bispecific antibodies (BsAbs) for therapeutic applications has been made. BsAbs… (More)
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Review
2015
Review
2015
Bispecific antibodies are on the cusp of coming of age as therapeutics more than half a century after they were first described… (More)
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Highly Cited
2011
Highly Cited
2011
We describe a generic approach to assemble correctly two heavy and two light chains, derived from two existing antibodies, to… (More)
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Highly Cited
2000
Highly Cited
2000
Although bispecific antibodies directed against malignant lymphoma have been shown to be effective in vitro and in vivo, extended… (More)
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Review
1997
Review
1997
Multivalency is one of the hallmarks of antibodies, by which enormous gains in functional affinity, and thereby improved… (More)
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Highly Cited
1996
Highly Cited
1996
A major hurdle to adenovirus (Ad)-mediated gene transfer is that the target issue lacks sufficient levels of receptors to mediate… (More)
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Highly Cited
1995
Highly Cited
1995
Construction of a bispecific single-chain antibody derivative is described that consists of two different single-chain Fv… (More)
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Highly Cited
1993
Highly Cited
1993
Bivalent and bispecific antibodies and their fragments have immense potential for practical application. Here we describe the… (More)
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