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Antibodies, Bispecific

Known as: Bispecific Antibody, Bispecific Antibodies, bsAb 
Antibodies, often monoclonal, in which the two antigen-binding sites are specific for separate ANTIGENIC DETERMINANTS. They are artificial antibodies… 
National Institutes of Health

Related topics

Related topics

20 relations

Narrower (12)

AMG 330Bi20 antibodyBispecific Monoclonal AntibodiesMDX-H210 antibody
Antibody SpecificityImmunologic CytotoxicityImmunotoxinsIn Blood

Broader (1)

Immunologic Factors

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Abstract 32: Preclinical evaluation of MCLA-158: A bispecific antibody targeting LGR5 and EGFR using patient-derived colon carcinoma organoids
Background. Colorectal cancer (CRC) is the third most common cancer and remains a large unmet need. Dysregulation of Wnt and… 
2015
2015
Relative antigen levels affect bispecific antibody behavior 1 Impact of Cell-Surface Antigen Expression on Target Engagement and Function of an EGFR x c-Met Bispecific Antibody *
The efficacy of engaging multiple drug targets using bispecific antibodies (BsAbs) is affected by the relative cell surface… 
2012
2012
Engineering a CD 123 xCD 3 bispecific scFv immunofusion for the treatment of leukemia and elimination of leukemia stem cells
Engineered bispecific antibodies that recruit cytotoxic lymphocytes to kill specific tumor cells have been showing promising… 
2011
2011
Bispecific Antibodies and Immune Therapy Targeting
The recent clinical and commercial success of therapeutic antibodies has generated great interest in antibody-based therapeutics… 
2010
2010
Readily isolated bispecific antibodies with native immunoglobulin format
FIELD: chemistry. SUBSTANCE: invention relates to biochemistry. Described is a bispecific antigen-binding protein which is… 
2010
2010
Abstract P6-15-15: MM-111 - A Novel Bispecific Antibody Targeting HER-2/HER-3 Z Heterodimer: Safety and Tolerability in a First-In Human Phase I/II Study in Patients with Refractory HER2-Positive…
Background: The ErbB2/ErbB3 oncogenic heterodimer is the most potent ErbB receptor pairing with respect to strength of… 
2009
2009
Protein engineering for targeted delivery of radionuclides to tumors
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, February 2010. 
Review
1992
Review
1992
Antibody-directed therapy of multidrug-resistant tumor cells
The major obstacle to effective cancer chemotherapy is the resistance of tumor cells to cytostatic agents. Tumor cells frequently… 
1988
1988
Targeting of cytotoxic cells against tumors with heterocrosslinked, bispecific antibodies.
Cytotoxic cells express specific receptors on their surfaces by which they distinguish altered or foreign cells from normal… 
1985
1985
Preparation and biomedical applications of bispecific antibodies.
Bispecific antibodies are immunoglobulin molecules with two different antigen binding sites. They can be prepared either by…