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Antibodies, Bispecific

Known as: Bispecific Antibody, Bispecific Antibodies, bsAb 
Antibodies, often monoclonal, in which the two antigen-binding sites are specific for separate ANTIGENIC DETERMINANTS. They are artificial antibodies… 
National Institutes of Health

Papers overview

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Review
2019
Review
2019
The term bispecific antibody (bsAb) is used to describe a large family of molecules designed to recognize two different epitopes… 
Review
2017
Review
2017
ABSTRACT During the past two decades we have seen a phenomenal evolution of bispecific antibodies for therapeutic applications… 
Review
2012
Review
2012
Monoclonal antibodies are widely used for the treatment of cancer, inflammatory and infectious diseases and other disorders. Most… 
Highly Cited
2012
Highly Cited
2012
Hemophilia A is a bleeding disorder resulting from coagulation factor VIII (FVIII) deficiency. Exogenously provided FVIII… 
Highly Cited
2011
Highly Cited
2011
We describe a generic approach to assemble correctly two heavy and two light chains, derived from two existing antibodies, to… 
Highly Cited
2011
Highly Cited
2011
Brain uptake of a therapeutic bispecific antibody by receptor-mediated transcytosis is enhanced by reducing the antibody’s… 
Highly Cited
2002
Highly Cited
2002
A recent study reported on an anti‐CD19/anti‐CD3 single‐chain bispecific antibody (bscCD19xCD3) exhibiting high activity against… 
Highly Cited
2000
Highly Cited
2000
Although bispecific antibodies directed against malignant lymphoma have been shown to be effective in vitro and in vivo, extended… 
Highly Cited
1995
Highly Cited
1995
Construction of a bispecific single-chain antibody derivative is described that consists of two different single-chain Fv… 
Highly Cited
1993
Highly Cited
1993
Bivalent and bispecific antibodies and their fragments have immense potential for practical application. Here we describe the…