Immunotoxins

Known as: Antibody-toxin conjugates, Hybrids, Antibody-Toxin, Toxin-Antibody Hybrids 
Semisynthetic conjugates of various toxic molecules, including RADIOACTIVE ISOTOPES and bacterial or plant toxins, with specific immune substances… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1936-2017
020040060019362016

Papers overview

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Review
2016
Review
2016
Immunotoxins are chimeric proteins obtained by linking a toxin to either an intact antibody or an antibody fragment. Conjugation… (More)
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Highly Cited
2009
Highly Cited
2009
BACKGROUND We investigated the long-term outcome of gene therapy for severe combined immunodeficiency (SCID) due to the lack of… (More)
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Highly Cited
2008
Highly Cited
2008
Recombinant immunotoxins are hybrid proteins composed of an Fv that binds to a tumor antigen fused to a bacterial or plant toxin… (More)
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Highly Cited
2007
Highly Cited
2007
PURPOSE To determine the toxicities, maximum tolerated dose (MTD) and pharmacokinetics of the recombinant immunotoxin SS1P (anti… (More)
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Highly Cited
2004
Highly Cited
2004
Immune responses against pathogens require that microbial components promote the activation of antigen-presenting cells (APCs… (More)
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Highly Cited
1999
Highly Cited
1999
PURPOSE Overexpression of the HER2 protein occurs in 25% to 30% of human breast cancers and leads to a particularly aggressive… (More)
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Highly Cited
1998
Highly Cited
1998
A growing number of human tumor antigens have been described that can be recognized by cytotoxic T lymphocytes (CTLs) in a major… (More)
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Highly Cited
1991
Highly Cited
1991
Fifteen patients with refractory B-cell lymphoma were treated in a Phase I dose escalation clinical trial with a highly potent… (More)
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Highly Cited
1983
Highly Cited
1983
We have induced the stable expression of muscle-specific genes in human nonmuscle cells. Normal diploid human amniocytes were… (More)
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Highly Cited
1982
Highly Cited
1982
Anthrax toxin is composed of three proteins: protective antigen (PA), lethal factor (LF), and edema factor (EF). These proteins… (More)
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