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Immunoconjugates

Known as: Icon, Immunoconjugate, Immunoconjugates [Chemical/Ingredient] 
Combinations of diagnostic or therapeutic substances linked with specific immune substances such as IMMUNOGLOBULINS; MONOCLONAL ANTIBODIES; or… Expand
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
PURPOSE Inotuzumab ozogamicin (CMC-544) is an antibody-targeted chemotherapy agent composed of a humanized anti-CD22 antibody… Expand
Highly Cited
2008
Highly Cited
2008
The linker component of antibody-drug conjugates (ADC) is a key feature in developing optimized therapeutic agents that are… Expand
Review
2005
Review
2005
Immunoconjugates—monoclonal antibodies (mAbs) coupled to highly toxic agents, including radioisotopes and toxic drugs… Expand
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Highly Cited
2005
Highly Cited
2005
Immunoconjugates are being explored as novel cancer therapies with the promise of target‐specific drug delivery. The… Expand
Highly Cited
2005
Highly Cited
2005
Effective antibody-drug conjugates (ADC) combine high drug-linker stability in circulation and efficient intratumoral release of… Expand
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Highly Cited
2004
Highly Cited
2004
Antibody-targeted chemotherapy with gemtuzumab ozogamicin (CMA-676, a CD33-targeted immunoconjugate of N-acetyl-gamma… Expand
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Highly Cited
2002
Highly Cited
2002
The anticancer drug doxorubicin (DOX) has been linked to chimeric BR96, an internalizing monoclonal antibody that binds to a… Expand
Highly Cited
1999
Highly Cited
1999
Leukemic blast cells express the CD33 antigen in most patients with acute myeloid leukemia (AML), but this antigen is not… Expand
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Highly Cited
1993
Highly Cited
1993
Immunoconjugates (BR96-DOX) were prepared between chimeric monoclonal antibody BR96 and the anticancer drug doxorubicin. The… Expand
Highly Cited
1992
Highly Cited
1992
The potential of immunoconjugates of cytotoxic drugs for the treatment of cancer has not yet been realized owing to the… Expand
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