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MDX-H210 antibody

Known as: 520C9xH22 bispecific antibody, bispecific antibody 520C9xH22, bispecific antibody 520C9x22 
A humanized bivalent antibody directed against both cytotoxic effector cells expressing Fc gamma receptor type I (Fc gammaRI, or CD64) and HER2/neu… 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (2)

Antibodies, BispecificAntibodies, Monoclonal, Humanized
NCIt Antineoplastic Agent Terminology

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2013
Highly Cited
2013
Elevated specific peripheral cytokines found in major depressive disorder patients with childhood trauma exposure: a cytokine antibody array analysis.
Highly Cited
2010
Highly Cited
2010
Dose-dependent restoration of dystrophin expression in cardiac muscle of dystrophic mice by systemically delivered morpholino
We have earlier shown that antisense morpholino oligomers are able to restore dystrophin expression by systemic delivery in body… 
Review
2006
Review
2006
Monoclonal and bispecific antibodies as novel therapeutics
Abstract.Gene amplification, over-expression, and mutation of growth factors, or the receptors themselves, causes increased… 
Highly Cited
2005
Highly Cited
2005
Characterization of a self-assembled monolayer of thiol on a gold surface and the fabrication of a biosensor chip based on surface plasmon resonance for detecting anti-GAD antibody.
Highly Cited
2003
Highly Cited
2003
Phase I clinical trial of the bispecific antibody MDX-H210 (anti-FcγRI × anti-HER-2/neu) in combination with Filgrastim (G-CSF) for treatment of advanced breast cancer
A phase I study of the bispecific antibody MDX-H210 in combination with granulocyte colony-stimulating factor (G-CSF) was… 
Highly Cited
2000
Highly Cited
2000
Targeting of adenoviral vectors through a bispecific single-chain antibody
Recombinant adenoviral vectors are attractive in the context of cancer gene therapy because they are capable of delivering genes… 
Highly Cited
1999
Highly Cited
1999
Maturation of dendritic cells accompanies high-efficiency gene transfer by a CD40-targeted adenoviral vector.
Important therapeutic applications of genetically modified dendritic cells (DC) have been proposed; however, current vector… 
Highly Cited
1996
Highly Cited
1996
Specific killing of lymphoma cells by cytotoxic T-cells mediated by a bispecific diabody.
Antibody fragments produced by bacterial fermentation lack natural effector functions. Bispecific antibody fragments, however… 
Highly Cited
1995
Highly Cited
1995
Phase Ia/Ib trial of bispecific antibody MDX-210 in patients with advanced breast or ovarian cancer that overexpresses the proto-oncogene HER-2/neu.
PURPOSE MDX-210 is a bispecific antibody that binds simultaneously to type I Fc receptors for immunoglobulin G (IgG) (Fc gamma RI… 
Highly Cited
1994
Highly Cited
1994
Construction, expression, and activity of a bivalent bispecific single-chain antibody.
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