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Regulation of inflammation by PPARs: a future approach to treat lung inflammatory diseases?
The present article reviews the current knowledge of the role of PPARα and PPARγ in controlling inflammation, and presents different findings suggesting that PPAR α andPPARγ activators may be helpful in the treatment of lung inflammatory diseases. Expand
Regulation of peroxisome proliferator-activated receptor-alpha expression during lung inflammation.
The data showed that PPARalpha is constitutively expressed in mouse lung and down-regulated in response to TNF-alpha or upon acute or allergic airway inflammation, which is inversely regulated with lung inflammation. Expand
Small Neutralizing Molecules to Inhibit Actions of the Chemokine CXCL12*
The highest affinity molecule blocked chemotaxis of human peripheral blood lymphocytes ex vivo and was also active in vivo in a mouse model of allergic eosinophilic airway inflammation in which it detected inhibition of the inflammatory infiltrate. Expand
Some aspects of IL‐8 pathophysiology III: chemokine interaction with endothelial cells
  • Antal Rot, Elin Hub, +7 authors Peter Dukor
  • Biology, Medicine
  • Journal of leukocyte biology
  • 1 January 1996
The results suggest that IL‐8 was internalized by the endothelial cells, transported transcellularly via plasmalemmal vesicles, and released onto the luminal surface where it appeared located preferentially on tips of membrane protrusions. Expand
PPARα downregulates airway inflammation induced by lipopolysaccharide in the mouse
The data clearly show that PPARα downregulates cell infiltration, chemoattractant production and enhanced MMP activity triggered by LPS in mouse lung, suggesting thatPPARα activation may have a beneficial effect in acute or chronic inflammatory airway disorders involving neutrophils and macrophages. Expand
Mediation of annexin 1 secretion by a probenecid-sensitive ABC-transporter in rat inflamed mucosa.
Results show that annexin 1 secretion appears to share the efflux properties of ABC-transporter substrates, and is inhibited in a dose-dependent manner by two ATPase inhibitors. Expand
Role of platelet‐activating factor (PAF) in platelet accumulation in rabbit skin: effect of the novel long‐acting PAF antagonist, UK‐74,505
The results suggest that PAF is an important mediator of oedema formation and platelet accumulation in the RPA reaction in rabbit skin and question the role of PAF receptors on platelets in this model. Expand
Upregulation of nerve growth factor expression by human airway smooth muscle cells in inflammatory conditions
The present study clearly shows that the human airway smooth muscle cell is a source of nerve growth factor, the expression of which is upregulated in inflammatory conditions, mimicked in vitro by the addition of interleukin-1β. Expand
Study of the toxicity of a new lipid complex formulation of amphotericin B.
LC-AmB reduced both the haemolytic activity of amphotericin B and its toxicity towards mouse peritoneal macrophages, and did not induce any new toxicity compared with Abelcet and Fungizone. Expand
Exposure to Endotoxins during Sensitization Prevents Further Endotoxin-Induced Exacerbation of Airway Inflammation in a Mouse Model of Allergic Asthma
Exposure to endotoxins during sensitization prevents allergen-induced airway inflammation, as well as its exacerbation triggered by further exposure to endotoxin during challenge, while switching the immune response to allergenic from a Th2 to a Th1 profile. Expand