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bisantrene dihydrochloride

Known as: Orange Crush, 9,10-Anthracenedicarboxakdehyde Bis[(4,5-dihydro-1H-imidazol-2-yl)hydrazone] Dihydrochloride, 9,10-Anthracenedicarboxaldehyde Bis(2-imidazolin-2-yl)hydrazone Dihydrochloride 
The hydrochloride salt of an anthracenyl bishydrazone with antineoplastic activity. Bisantrene intercalates with and disrupts the helical structure… 
National Institutes of Health

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CL 216942
bisantrene

Papers overview

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2004
2004
Bisantrene solubility and skin toxicity studies: Efficacy of sodium bicarbonate as a local ulceration antidote
SummaryBisantrene solubility and skin toxicity were studied in mice given intraperitoneal (IP) and intradermal (ID) drug… 
2004
2004
Phase I clinical and pharmacokinetic study of bisantrene in refractory pediatric solid tumors
SummaryFourteen patients with pediatric malignant solid tumors, median age 15 years, received 22 courses of bisantrene in a Phase… 
2004
2004
Blood and tissue concentrations of Bisantrene measured by a simple fluorometric assay
SummaryWe have developed a simple sensitive fluorometric assay for the measurement of total Bisantrene in plasma, red blood cells… 
1987
1987
Phase II evaluation of bisantrene hydrochloride in refractory malignant melanoma. A Southwest Oncology Group Study.
Patients with a pathologically proven diagnosis of malignant melanoma were entered into a phase II trial of bisantrene… 
1986
1986
Bisantrene hydrochloride in gastric adenocarcinoma: a Southwest Oncology Group Study.
Because "the standard" chemotherapy for advanced gastric adenocarcinoma, the FAM combination of 5-fluorouracil, adriamycin, and… 
1983
1983
Light, fluorescent, and electron microscopic analysis of cultured breast tumor cells (T-47D) treated with 9,10-anthracenedicarboxaldehyde bis[(4,5-dihydro-1H-imidazol-2-yl)hydrazone] dihydrochloride.
The influence of bisantrene on T-47D human breast tumor cells was assessed by colony-forming assay in soft agar and by light… 
1982
1982
Molecular pharmacology of the anthracycline drug 9,10-anthracenedicarboxaldehyde bis[(4,5-dihydro-1 H-imidazol-2-yl)hydrazone] dihydrochloride (Cl 216,942).
9,10-Anthracenedicarboxyaldehyde bis[(4,5-dihydro-1H-imidazol-2yl)hydrazone] dihydrochloride (Cl 216,942) is a new anthracene… 
1982
1982
Activity of a novel anthracenyl bishydrazone, 9,10-anthracenedicarboxyaldehyde Bis[(4,5-dihydro-1H-imidazol-2-yl)hydrazone] dihydrochloride, against experimental tumors in mice.
9,10-Anthracenedicarboxaldehyde bis[(4,5-dihydro-1H-imidazol-2-yl)hydrazone] dihydrochloride (CL 216942; bisantrene hydrochloride… 
1982
1982
Bisantrene phlebitis may be related to intravascular deposition of drug
Highly Cited
1981
Highly Cited
1981
Phase I clinical investigation of 9,10-anthracenedicarboxaldehyde bis[(4,5-dihydro-1 H-imidazol-2-yl)hydrazone] dihydrochloride (CL216,942).
9,10-Anthracenedicarboxaldehyde bis[(4,5-dihydro-1 H-imidazol-2-yl)hydrazone] dihydrochloride (CL216,942) is a new anthracene… 
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