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Molecular classification of cutaneous malignant melanoma by gene expression profiling
TLDR
Many genes underlying the classification of this subset of melanomas are differentially regulated in invasive melanomas that form primitive tubular networks in vitro, a feature of some highly aggressive metastatic melanomas. Expand
Concurrent chemotherapy and pelvic radiation therapy compared with pelvic radiation therapy alone as adjuvant therapy after radical surgery in high-risk early-stage cancer of the cervix.
TLDR
The addition of concurrent cisplatin-based CT to RT significantly improves progression-free and overall survival for high-risk, early-stage patients who undergo radical hysterectomy and pelvic lymphadenectomy for carcinoma of the cervix. Expand
Intraperitoneal cisplatin plus intravenous cyclophosphamide versus intravenous cisplatin plus intravenous cyclophosphamide for stage III ovarian cancer.
TLDR
Intraperitoneal cisplatin significantly improves survival and has significantly fewer toxic effects in patients with stage III ovarian cancer and residual tumor masses of 2 cm or less. Expand
Effects of Dosing Condition on the Oral Bioavailability of Green Tea Catechins after Single-Dose Administration of Polyphenon E in Healthy Individuals
TLDR
It is concluded that greater oral bioavailability of free catechins can be achieved by taking the Polyphenon E capsules on an empty stomach after an overnight fast, and this dosing condition is also expected to optimize the biological effects of teacatechins. Expand
Phase III trial of standard-dose intravenous cisplatin plus paclitaxel versus moderately high-dose carboplatin followed by intravenous paclitaxel and intraperitoneal cisplatin in small-volume stage
TLDR
An experimental regimen including moderately high-dose IV carboplatin followed by IP paclitaxel and IV cisplatin yielded a significant improvement in progression-free survival when compared with a standard regimen of IV cis Platin and pac Litaxel. Expand
A pooled analysis of advanced colorectal neoplasia diagnoses after colonoscopic polypectomy.
TLDR
Factors that are associated most strongly with risk of advanced neoplasia are patient age and the number and size of prior adenomas. Expand
Pharmacokinetics and safety of green tea polyphenols after multiple-dose administration of epigallocatechin gallate and polyphenon E in healthy individuals.
TLDR
It is safe for healthy individuals to take green tea polyphenol products in amounts equivalent to the EGCG content in 8-16 cups of green tea once a day or in divided doses twice a day for 4 weeks, and the pharmacokinetics of the conjugated metabolites of epigallocatechin and epicatechin were not affected by repeated green teapolyphenol treatment. Expand
MGMT promoter methylation and field defect in sporadic colorectal cancer.
TLDR
Some colorectal cancers arise from a field defect defined by epigenetic inactivation of MGMT, and detection of this abnormality may ultimately be useful in risk assessment for coloreCTal cancer. Expand
Resveratrol Modulates Drug- and Carcinogen-Metabolizing Enzymes in a Healthy Volunteer Study
TLDR
It is concluded that resveratrol can modulate enzyme systems involved in carcinogen activation and detoxification, which may be one mechanism by which resver atrol inhibits carcinogenesis. Expand
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