bisantrene

Known as: 9,10-Anthracenedicarboxaldehyde, bis((4,5-dihydro-1H-imidazol-2-yl)hydrazone), 9,10-Anthracenedicarboxaldehyde Bis(2-imidazolin-2-yl)hydrazone, 9,10,Anthracenedicarboxaldehyde 
An anthracenyl bishydrazone with antineoplastic activity. Bisantrene intercalates with and disrupts the configuration of DNA, resulting in DNA single… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1978-2018
0102019782018

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Highly Cited
2012
Highly Cited
2012
Lung cancer is mainly caused by smoking, but the quantitative relations between smoking and histologic subtypes of lung cancer… (More)
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Highly Cited
2008
Highly Cited
2008
Cancers arise by the gradual accumulation of mutations in multiple genes. We now use shotgun pyrosequencing to characterize RNA… (More)
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Highly Cited
2003
Highly Cited
2003
Recent studies have shown that mutations at amino-acid 482 in the ABCG2 gene affect the substrate specificity of the protein. To… (More)
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Highly Cited
2002
Highly Cited
2002
The pathological distinction between malignant pleural mesothelioma (MPM)and adenocarcinoma (ADCA) of the lung can be cumbersome… (More)
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2001
2001
Recent studies of the p53 homologue p63 indicate that this gene is preferentially expressed in basal and immature cervical… (More)
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Highly Cited
2000
Highly Cited
2000
Mechanisms of drug resistance other than P-glycoprotein are of increasing interest as the list of newly identified members of the… (More)
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Highly Cited
1995
Highly Cited
1995
Proton magnetic resonance spectroscopy (MRS) and MRI were carried out in 11 patients with multiple sclerosis who had clinical… (More)
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1994
1994
Bisantrene, mitoxantrone, and anthracyclines are anthracene derivatives that interact with DNA and are used for the treatment of… (More)
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Highly Cited
1994
Highly Cited
1994
Fifty-eight cell lines in the National Cancer Institute drug screen were analyzed for their ability to efflux the fluorescent dye… (More)
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1985
1985
1,4-Dihydroxy-5,8-bis(2-[(2-hydroxyethyl)aminoethyl]amino)-9, 10-anthracenedione (mitoxantrone) and 9,10… (More)
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