Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43).
- T. Iwatsubo, A. Odaka, N. Suzuki, H. Mizusawa, N. Nukina, Y. Ihara
- BiologyNeuron
- 1994
Two familial AD cortices with the mutation of beta-amyloid protein precursor 717 (beta APP717) (Val to Ile) showed a remarkable predominance of A beta 42(43)-positive, A beta 40-negative plaques.
Ultrasensitive human prion detection in cerebrospinal fluid by real-time quaking-induced conversion
- R. Atarashi, K. Satoh, N. Nishida
- BiologyNature Network Boston
- 1 February 2011
A new PrPSc amplification assay, called real-time quaking-induced conversion (RT-QUIC), which allows the detection of ≥1 fg ofPrPSc in diluted Creutzfeldt-Jakob disease (CJD) brain homogenate, and indicates the promising enhanced diagnostic capacity of RT- QUIC in the antemortem evaluation of suspected CJD.
Delayed-onset ataxia in mice lacking α-tocopherol transfer protein: Model for neuronal degeneration caused by chronic oxidative stress
- T. Yokota, Keiji Igarashi, H. Arai
- BiologyProceedings of the National Academy of Sciences…
- 18 December 2001
This therapy almost completely corrects the abnormalities in a mouse model of human neurodegenerative disease and α-TTP−/− mice may prove to be excellent animal models of delayed onset, slowly progressive neuronal degeneration caused by chronic oxidative stress.
Visualization of Aβ42(43) and Aβ40 in senile plaques with end-specific Aβ monoclonals: Evidence that an initially deposited species is Aβ42(43)
- T. Iwatsubo, A. Odaka, N. Suzuki, H. Mizusawa, N. Nukina, Y. Ihara
- BiologyNeuron
- 1 July 1994
Prospective 10-year surveillance of human prion diseases in Japan.
- I. Nozaki, T. Hamaguchi, M. Yamada
- MedicineBrain : a journal of neurology
- 1 October 2010
A frequent occurrence of dura mater graft-associated Creutzfeldt-Jakob disease, and unique phenotypes of sporadic Creutzfelder disease and genetic prion diseases related to the characteristic distribution of prion protein gene mutations and polymorphisms in Japan, compared with those in western countries are revealed.
Down regulation of DJ-1 enhances cell death by oxidative stress, ER stress, and proteasome inhibition.
- T. Yokota, K. Sugawara, Kaoru Ito, R. Takahashi, H. Ariga, H. Mizusawa
- Biology, ChemistryBiochemical and Biophysical Research…
- 26 December 2003
Cognitive status correlates with white matter alteration in Parkinson's disease
- T. Hattori, S. Orimo, H. Mizusawa
- Psychology, BiologyHuman Brain Mapping
- 1 March 2012
The results suggest that white matter damage underlies cognitive impairment in PD, and cognitive impaired in PD progresses with functional alteration (hypoperfusion) followed by structural alterations in which white matter alteration precedes gray matter atrophy.
Quantifying prion disease penetrance using large population control cohorts
- E. Minikel, S. Vallabh, D. MacArthur
- BiologyScience Translational Medicine
- 20 January 2016
It is shown that missense variants in PRNP previously reported to be pathogenic are at least 30 times more common in the population than expected on the basis of genetic prion disease prevalence, a finding that supports the safety of therapeutic suppression of prion protein expression.
Spinocerebellar ataxia type 31 is associated with "inserted" penta-nucleotide repeats containing (TGGAA)n.
- N. Sato, T. Amino, H. Mizusawa
- BiologyAmerican Journal of Human Genetics
- 13 November 2009
R-spondin, a novel gene with thrombospondin type 1 domain, was expressed in the dorsal neural tube and affected in Wnts mutants.
- T. Kamata, K. Katsube, M. Michikawa, M. Yamada, S. Takada, H. Mizusawa
- BiologyBiochimica et Biophysica Acta
- 5 January 2004
...
...