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p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development
TLDR
It is reported that mice homozygous for a disrupted p63 gene have major defects in their limb, craniofacial and epithelial development, and results indicate that p63 is critical for maintaining the progenitor-cell populations that are necessary to sustain epithelialDevelopment and morphogenesis.
Intraepithelial Carcinoma of the Fimbria and Pelvic Serous Carcinoma: Evidence for a Causal Relationship
TLDR
TIC coexists with all forms of pelvic serous carcinoma and is a plausible origin for many of these tumors, although further studies are needed to elucidate the etiologic significance.
p63 Is Essential for the Proliferative Potential of Stem Cells in Stratified Epithelia
TLDR
P63, a gene whose deletion in mice results in the catastrophic loss of all stratified epithelia, is analyzed and it is demonstrated that p63 is strongly expressed in epithelial cells with high clonogenic and proliferative capacity and that stem cells lacking p63 undergo a premature proliferative rundown.
Landscape of genomic alterations in cervical carcinomas
TLDR
Several recurrent genomic alterations in cervical carcinomas are demonstrated that suggest new strategies to combat this disease.
The human VASA gene is specifically expressed in the germ cell lineage.
TLDR
It is shown by Northern analysis of fetal and adult tissues that expression of the human VASA gene is restricted to the ovary and testis and is undetectable in somatic tissues, which should be useful for studies of human germ cell determination and function.
The Tubal Fimbria Is a Preferred Site for Early Adenocarcinoma in Women With Familial Ovarian Cancer Syndrome
TLDR
The fimbria was the most common location for early serous carcinoma in this series of BRCA-positive women, and Investigative strategies targeting the fimbriated end of the fallopian tube should further define its role in the pathogenesis of familial and sporadic ovarianSerous carcinomas.
Distal Airway Stem Cells Yield Alveoli In Vitro and during Lung Regeneration following H1N1 Influenza Infection
TLDR
The dynamics of this p63-expressing stem cell in lung regeneration mirrors the parallel finding that defined pedigrees of human distal airway stem cells assemble alveoli-like structures in vitro and suggests new therapeutic avenues to acute and chronic airway disease.
Transformation of the fallopian tube secretory epithelium leads to high-grade serous ovarian cancer in Brca;Tp53;Pten models.
TLDR
This study demonstrates that high-grade serous tumors can originate in fallopian tubal secretory epithelial cells and establishes serous tubal intraepithelial carcinoma as the precursor lesion to high- grade serous ovarian and peritoneal carcinomas in animal models targeting the Brca, Tp53, and Pten genes.
p63 protects the female germ line during meiotic arrest
TLDR
It is shown that the p53 homologue p63, and specifically the TAp63 isoform, is constitutively expressed in female germ cells during meiotic arrest and is essential in a process of DNA damage-induced oocyte death not involving p53.
Ki-67, Cyclin E, and p16 INK4 Are Complimentary Surrogate Biomarkers for Human Papilloma Virus-Related Cervical Neoplasia
TLDR
Ki-67, cyclin E, and p16 are complementary surrogate biomarkers for HPV-related preinvasive squamous cervical disease and use of these biomarkers in combination for resolving diagnostic problems, with an appreciation of potential background staining, is recommended.
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