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- Publications
- Influence
p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development
- Annie Yang, Ronen Schweitzer, +8 authors F. McKeon
- Biology, Medicine
- Nature
- 22 April 1999
The p63 gene, a homologue of the tumour-suppressor p53 (refs 1–5), is highly expressed in the basal or progenitor layers of many epithelial tissues. Here we report that mice homozygous for a… Expand
Intraepithelial Carcinoma of the Fimbria and Pelvic Serous Carcinoma: Evidence for a Causal Relationship
- D. Kindelberger, Y. Lee, +10 authors C. Crum
- Biology, Medicine
- The American journal of surgical pathology
- 1 February 2007
Proposed origins of pelvic serous carcinoma include the ovary, fallopian tube, and peritoneum. Prophylactic salpingo-oophorectomies in BRCA+ women have recently identified the fimbria as a site of… Expand
p63 Is Essential for the Proliferative Potential of Stem Cells in Stratified Epithelia
- Makoto Senoo, F. Pinto, C. Crum, F. Mckeon
- Biology, Medicine
- Cell
- 4 May 2007
The distinguishing feature of adult stem cells is their extraordinary capacity to divide prior to the onset of senescence. While stratified epithelia such as skin, prostate, and breast are highly… Expand
The Tubal Fimbria Is a Preferred Site for Early Adenocarcinoma in Women With Familial Ovarian Cancer Syndrome
- F. Medeiros, M. Muto, +6 authors C. Crum
- Biology, Medicine
- The American journal of surgical pathology
- 1 February 2006
A proportion of adenocarcinomas in prophylactic adnexectomies (bilateral salpingo-oophorectomies [BSOs]) from women with BRCA mutations (BRCA positive) occur in the fallopian tube. We analyzed a… Expand
Landscape of genomic alterations in cervical carcinomas
- A. I. Ojesina, L. Lichtenstein, +53 authors M. Meyerson
- Biology, Medicine
- Nature
- 20 February 2014
Cervical cancer is responsible for 10–15% of cancer-related deaths in women worldwide. The aetiological role of infection with high-risk human papilloma viruses (HPVs) in cervical carcinomas is well… Expand
Transformation of the fallopian tube secretory epithelium leads to high-grade serous ovarian cancer in Brca;Tp53;Pten models.
- Ruth Perets, Gregory A. Wyant, +13 authors R. Drapkin
- Biology, Medicine
- Cancer cell
- 9 December 2013
High-grade serous ovarian carcinoma presents significant clinical and therapeutic challenges. Although the traditional model of carcinogenesis has focused on the ovary as a tumor initiation site,… Expand
The human VASA gene is specifically expressed in the germ cell lineage.
- D. Castrillon, B. Quade, T. Y. Wang, C. Quigley, C. Crum
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 15 August 2000
To understand the origins and function of the human germ cell lineage and to identify germ cell-specific markers we have isolated a human ortholog of the Drosophila gene vasa. The gene was mapped to… Expand
Distal Airway Stem Cells Yield Alveoli In Vitro and during Lung Regeneration following H1N1 Influenza Infection
The extent of lung regeneration following catastrophic damage and the potential role of adult stem cells in such a process remains obscure. Sublethal infection of mice with an H1N1 influenza virus… Expand
The human papillomavirus type 16 E6 and E7 oncoproteins cooperate to induce mitotic defects and genomic instability by uncoupling centrosome duplication from the cell division cycle.
- S. Duensing, L. Lee, +5 authors K. Munger
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 29 August 2000
Loss of genomic integrity is a defining feature of many human malignancies, including human papillomavirus (HPV)-associated preinvasive and invasive genital squamous lesions. Here we show that… Expand
Ki-67, Cyclin E, and p16 INK4 Are Complimentary Surrogate Biomarkers for Human Papilloma Virus-Related Cervical Neoplasia
- J. T. Keating, A. Cviko, +7 authors C. Crum
- Biology, Medicine
- The American journal of surgical pathology
- 1 July 2001
Prior studies of Ki-67, cyclin E, and p16 expression have suggested that these biomarkers may be preferentially expressed in cervical neoplasia. This study examined and compared the distribution of… Expand