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Molecular and biochemical pharmacology of mitoxantrone.
Preparation and characterization of monoclonal antibody conjugates of the calicheamicins: a novel and potent family of antitumor antibiotics.
- L. Hinman, P. Hamann, R. Wallace, A. Menendez, F. Durr, J. Upeslacis
- Chemistry, BiologyCancer research
- 15 July 1993
The calicheamicin family of antitumor antibiotics are capable of producing double-stranded DNA breaks at sub-picomolar concentrations. Their potency suggested that the calicheamicins would be…
Activity of a novel anthracenyl bishydrazone, 9,10-anthracenedicarboxyaldehyde Bis[(4,5-dihydro-1H-imidazol-2-yl)hydrazone] dihydrochloride, against experimental tumors in mice.
- R. Citarella, R. Wallace, K. C. Murdock, R. Angier, F. Durr, M. Forbes
- Chemistry, MedicineCancer research
- 1 February 1982
The drug was cytotoxic for rapidly proliferating and nonproliferating human colon carcinoma WiDR cells in vitro and was a potent inhibitor of DNA and RNA synthesis in L5178Y lymphoma cells cultured in vitro, and preliminary studies indicated the drug was a DNA-intercalating agent.
P-glycoprotein mediates profound resistance to bisantrene.
It is shown that cells that overexpress low levels of P-glycoprotein or are transfected with human MDR1 have approximately 10-fold greater resistance to bisantrene compared to vinblastine, doxorubicin, or colchicine.
Antitumor agents. 1. 1,4-Bis[(aminoalkyl)amino]-9,10-anthracenediones.
Alkylenediamines condensation with quinizarin or with 2,3-dihydro-1,4,5,8-tetrahydroxy-9,10-anthracenedione, followed by oxidation, gave 1,4-bis[aminoalkyl)amino]-9, 10-Anthracenediones, indicating the importance of hydrophilicity.
Development of mitoxantrone
Preclinical studies in several animal models indicate that mitoxantrone does not have the cumulative cardiotoxic liability associated with anthracycline antibiotics such as doxorubicin and combination studies with standard anticancer agents gave evidence of therapeutic synergy in a number of cases.
ANTITUMOR AGENTS. 1. 1,4-BIS((AMINOALKYL)AMINO)-9,10-ANTHRACENEDIONES
Arabinofuranosyl-5-azacytosine: activity against human tumors in athymic mice
Ara-AC is a promising new compound that may have utility in the treatment of human cancer beyond that anticipated for a cytotoxic nucleoside.
Activity of a novel anthracenedione, 1,4-dihydroxy-5,8-bis(((2-[(2-hydroxyethyl)amino]ethyl)amino])-9,10-anthracenedione dihydrochloride, against experimental tumors in mice.
The compound produced significant increases in life span (ILS) and long-term survivors when tested against the P388 and L1210 leukemias as well as the solid neoplasms, B16 melanoma and Colon Tumor 26.
Studies on the infectivity and cytopathology of epstein‐barr virus in human lymphoblastoid cells
- F. Durr, J. H. Monroe, R. Schmitter, K. Traul, Y. Hirshaut
- Biology, MedicineInternational journal of cancer
- 15 November 1970
The infectivity of EB virus recovered from cultures of P‐3J and the HR1K clone of this cell line has been demonstrated in established lymphoblastoid cell lines derived from healthy human donors and…